Article
Chemistry, Multidisciplinary
Ximin Yuan, Zhou Zhu, Pengcheng Xia, Zhenjia Wang, Xiao Zhao, Xiao Jiang, Tianming Wang, Qing Gao, Jie Xu, Debin Shan, Bin Guo, Qingqiang Yao, Yong He
Summary: Tough hydrogel is difficult to be used for tissue regeneration due to its poor biocompatibility, nondegradation, and compositional differences from natural tissues. This study proposes a gelatin-based tough hydrogel (GBTH) that overcomes these limitations. GBTH exhibits excellent tensile strength and can be sutured to ruptured tendons, promoting tendon differentiation and allowing quick return to the initial state within eight weeks. This strategy provides a new avenue for highly biocompatible tough hydrogel preparation for tissue regeneration.
Article
Nanoscience & Nanotechnology
Rong Wang, Lingbin Che, Qian Feng, Kaiyong Cai
Summary: This paper presents the design of a tough and flexible amphoteric copolymer-based hydrogel for bone regeneration, which shows good osteogenesis induction and osseointegration. The hydrogel is copolymerized with N-acyl glycinamide (NAGA), anionic acrylate alendronate (AcAln), and cationic (2-(acryloyloxy)ethyl) trimethyl ammonium chloride (DMAEA-Q), and contains three types of physical cross-links. In vitro and in vivo experiments demonstrate the excellent osteogenic properties of the hydrogel.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Yusser Olguin, Soledad Acuna-Mendoza, Carolina Otero, Cristian A. Acevedo, Cristian Covarrubias
Summary: Modulating the bio-regenerative characteristics of materials is crucial in tissue engineering, especially in bone tissue engineering where the promotion of osteoconduction determines the therapeutic properties of the material. In addition to chemical qualities, the three-dimensional surface structure plays a fundamental role and can be modulated through various methods, one of which is the use of different types of radiation.
Article
Biochemistry & Molecular Biology
Tatiana I. Vinogradova, Mikhail S. Serdobintsev, Evgenia G. Korzhikova-Vlakh, Viktor A. Korzhikov-Vlakh, Alexander S. Kaftyrev, Natalya M. Blum, Natalya Yu. Semenova, Dilyara S. Esmedlyaeva, Marina E. Dyakova, Yulia A. Nashchekina, Marine Z. Dogonadze, Natalia V. Zabolotnykh, Petr K. Yablonsky
Summary: This study compared the effects of autografting and implantation with a biodegradable composite scaffold for bone-defect regeneration in a tuberculosis rabbit model. The results showed that the porous three-dimensional composite materials prepared by 3D printing could promote bone regeneration and healing. This has important implications for the treatment of tuberculosis patients.
Article
Nanoscience & Nanotechnology
Mutian Hua, Dong Wu, Shuwang Wu, Yanfei Ma, Yousif Alsaid, Ximin He
Summary: Hydrogels with stimuli-responsive volume changing abilities are being used in soft actuators and robots, but traditional tough hydrogels cannot satisfy both high toughness and high stimuli responsiveness. This study introduces a material design that combines responsive and tough components in a single hydrogel network, allowing for the synergistic realization of high toughness and actuation performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Chemistry, Physical
Simin Paknia, Zhila Izadi, Majid Moosaipour, Sajad Moradi, Balal Khalilzadeh, Mehdi Jaymand, Hadi Samadian
Summary: This study aimed to integrate the unique benefits of electroconductive hydrogel scaffold and hydroxyapatite (HAp) crystals in the repair of bone defects. HAp crystals were synthesized and dopamine-aniline copolymer (PDA-co-PANI) were synthesized through a chemical oxidation polymerization approach. The prepared hydrogel possesses good electrical conductivity and is compatible with bone cell growth, making it effective for repairing bone lesions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Environmental
Ruixue Li, Yang Sun, Zhengwei Cai, Yang Li, Jian Sun, Wei Bi, Fei Yang, Qianrong Zhou, Tingjun Ye, Youcheng Yu
Summary: A novel peptide hydrogel (HA-c-CGRP) was constructed in this study, which sustained release highly bioactive CGRP and promoted BMSCs proliferation and osteoblast differentiation. The cocrosslinking HA-c-CGRP hydrogel accelerated new bone formation process with the highly bioactive peptide, showing promising prospect for healing defected bone tissue.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Pengyue You, Yuhua Liu, Xinzhi Wang, Bowen Li, Weiyi Wu, Lin Tang
Summary: This study investigated the potential application of natural acellular porcine pericardium (APP) as a barrier membrane for guided bone regeneration (GBR). The results showed that APP exhibited osteoconductive and osteoinductive properties, promoting bone regeneration in a critical-sized calvarial defect model compared to collagen membrane and control group. Overall, APP demonstrated promising capabilities for GBR in terms of biomaterial properties and bone healing effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Leena Leelatian, Panjit Chunhabundit, Phingphol Charoonrut, Pattapon Asvanund
Summary: This study investigated the potential of nacre powder in promoting peri-implant bone regeneration in a porcine model. The results showed that dental implants coated with nacre powder had significantly higher bone-to-implant contact and bone volume density compared to implants without nacre powder. The histological study also supported these findings.
Article
Biochemistry & Molecular Biology
Karol Ali Apaza Alccayhuaman, Stefan Tangl, Stephane Blouin, Markus A. Hartmann, Patrick Heimel, Ulrike Kuchler, Jung-Seok Lee, Reinhard Gruber
Summary: In a rat cranial defect, VSCM shows limited and heterogeneous capacity to support intramembranous bone formation, but may potentially allow bone formation via the endochondral route.
Article
Materials Science, Biomaterials
Min He, Bo Yang, Fangjun Huo, Li Xie, Mo Yang, Weidong Tian
Summary: A metal-phenolic-based drug-loaded coating was developed to promote osteointegration by manipulating a beneficial osteoimmune microenvironment. The coating could release active components in inflammatory environments, showing synergistic effects on macrophage polarization to enhance osteogenic outcomes. This substrate-independent and quick-forming coating has great potential for advanced hard tissue implants with favorable osteoimmunomodulation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Long Bai, Ya Zhao, Peiru Chen, Xiangyu Zhang, Xiaobo Huang, Zhibin Du, Ross Crawford, Xiaohong Yao, Bin Tang, Ruiqiang Hang, Yin Xiao
Summary: The study demonstrates that surface nano-dimensions significantly influence clot formation, and appropriate clot features can manipulate a favorable osteoimmunomodulatory environment, promoting bone regeneration and osseointegration.
Article
Nanoscience & Nanotechnology
Anna Diez-Escudero, Elin Carlsson, Brittmarie Andersson, Josef D. Jarhult, Nils P. Hailer
Summary: Research has shown that silver-coated porous titanium scaffolds can inhibit the growth and biofilm formation of common PJI pathogens, while promoting normal metabolic activity and bone cell function in human osteoblasts. This technology has the potential to enhance osseointegration and reduce the risk of bacterial infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Jianping Mao, Pengfei Wei, Zuoying Yuan, Wei Jing, Jingjing Cao, Guangping Li, Jianxun Guo, Honggang Wang, Dafu Chen, Qing Cai
Summary: This study prepared microspheres with surface micropores using the double emulsion method, which showed increased cell affinity and enhanced osteogenic differentiation of BMSCs after further functionalization. By adsorbing BMP-2 onto the biomineralized microspheres, efficient ectopic osteogenesis was induced without causing biocompatibility problems. The study provided a simple strategy to prepare functionalized microspheres with great potential in promoting bone regeneration as injectable micro-scaffolds.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Physical
Jiao Xu, Zhenbao Luo, Sudong Wu, Yulei Li, Yun Yang, Shiyuan Lai, Fuzeng Ren, Jianjun Lin, Dengji Guo, Xujin Wang
Summary: Nanocrystalline diamond films were fabricated with a dual nanostructure by adjusting the CH4 content in the precursor gas, showing consistent lubricant properties and wear rates regardless of grain size variations. The films exhibited lower and more stable friction coefficients after irradiation due to reduced surface roughness and formation of tribofilms with a graphite-like structure. The excellent maintenance of lubrication properties post-heavy-ion irradiation suggests potential for development as anti-irradiation films in nuclear environments.
APPLIED SURFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Huan He, Ziying Fei, Tailin Guo, Yue Hou, Da Li, Kefeng Wang, Fuzeng Ren, Kelong Fan, Daijun Zhou, Chaoming Xie, Chao Wang, Xiong Lu
Summary: This study developed a bioadhesive injectable hydrogel for localized immune modulation and catalytic immunotherapy in cancer treatment. The hydrogel containing a nanozyme and immune adjuvant effectively targeted the tumor microenvironment while limiting systemic exposure and enhancing therapeutic efficacy.
Article
Biophysics
Mengyue Xian, Liming Fang, Yili Liu, Qiang Wei, Lijing Hao, Zhonghang Yu, Xianyun He, Gang Wu
Summary: The study found that electrical stimulation affects protein adsorption and cell behavior, regulating osteogenic differentiation by tuning cell adhesion and spreading.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Correction
Materials Science, Ceramics
Bo Lei, Xiaofeng Chen, Yingjun Wang, Naru Zhao, Chang Du, Liming Fang
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Multidisciplinary Sciences
Kai Shi, Likun Chen, Zipei Wan, Jie Biao, Guiming Zhong, Xue Li, Lu Yang, Jiabin Ma, Wei Lv, Fuzeng Ren, Hongqi Wang, Yong Yang, Feiyu Kang, Yan-Bing He
Summary: Ceramic electrolytes play a crucial role in solid-liquid batteries by solving interfacial issues and enabling efficient Li-ion transfer. This study confirms the Li-ion transport mechanism in ceramic electrolytes through solid-state nuclear magnetic resonance spectroscopy. The ceramic and liquid electrolytes both contribute to Li-ion transport and exhibit spontaneous Li-ion exchange, improving the continuity of Li-ion pathways.
Article
Nanoscience & Nanotechnology
Shanshan Lai, Yanjiao Wang, Yuanyuan Wan, Hang Ma, Liming Fang, Jianyu Su
Summary: In this study, a smart magnetoelectric coating was developed to give stainless steel adjustable electrical properties and antibacterial effects. The antibacterial mechanism of the coating was also explored. This research provides a new solution for the hygiene and cleaning of food processing devices.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Shan He, Ju Fang, Chuanxin Zhong, Fuzeng Ren, Min Wang
Summary: The study developed a non-viral DNA delivery nanocomplex that was immobilized onto a polydopamine-coated electrospun alginate nanofibrous scaffold, creating a gene-activated matrix (GAM) for enhanced skin wound healing. The nanocomplex showed low cytotoxicity and high transfection efficiency. The GAM enabled sustained gene release and long-term transgene expression, accelerating wound closure, promoting re-epithelization, reducing inflammatory response, and enhancing neovascularization in a rat model.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Jiao Xu, Zhenbao Luo, Yun Yang, Yuhang Liu, Fuzeng Ren, Jianjun Lin, Junhua Yu, Shiyuan Lai, He Zhang, Jiangtao Huang, Dengji Guo, Bin He, Xujin Wang
Summary: Experimental studies on nanocrystalline diamond films synthesized using hot-filament chemical vapor deposition showed that under large displacement damage conditions, the films exhibited ultrahigh wear resistance and maintained low-friction characteristics as irradiation damage increased.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jiasi Luo, Wanting Sun, Ranxi Duan, Wenqing Yang, K. C. Chan, Fuzeng Ren, Xu-Sheng Yang
Summary: In this study, a facile laser surface remelting-based surface treatment technique was used to fabricate a gradient nanostructured layer on a TiZrHfTaNb refractory high entropy alloy. The results showed that the average grain size in the gradient nanostructured layer was dramatically refined, leading to an increase in microhardness. The alloy composition also changed, forming decomposed multi-phases. The laser-treated TiZrHfTaNb high entropy alloy exhibited significantly improved wear resistance.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Coatings & Films
Haijuan Mei, Ji Cheng Ding, Zhenting Zhao, Qiuguo Li, Jinxiang Song, Yajie Li, Weiping Gong, Fuzeng Ren, Qimin Wang
Summary: The effect of copper content on the high-temperature tribological properties and oxidation behavior of Cu-containing coatings was studied. It was found that increasing copper content decreased the oxidation resistance of the coatings, but also reduced the friction coefficient and achieved a low wear rate.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Dingshan Liang, Qiuhong Wang, Kangjie Chu, Junyu Chen, Peng Hua, Fuzeng Ren, Qingping Sun
Summary: This study reports the ultrahigh fatigue life of nanocrystalline NiTi tubes, exceeding 120 million cycles, with stable cyclic stress-strain responses and a stable adiabatic temperature drop. The high resistance to nucleation and growth of compression-parallel cracks contributes to the ultrahigh fatigue life of the tubes.
APPLIED MATERIALS TODAY
(2022)
Article
Nanoscience & Nanotechnology
Qiwen Tang, Qi Ke, Qi Chen, Xinyi Zhang, Jianyu Su, Chengyun Ning, Liming Fang
Summary: A self-powered and intrinsic bactericidal patch based on a triboelectric nanogenerator (TENG) is proposed in this study. The patch is composed of electrospun polymer tribo-layers and a chemical vapor-deposited polypyrrole electrode, which provides excellent flexibility, breathability, and wettability. The patch kills over 96% of bacteria through electrical stimulation and promotes the healing of infected diabetic rat skin wounds within 2 weeks.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lei Yin, Qiwen Tang, Qi Ke, Xinyi Zhang, Jianyu Su, Hua Zhong, Liming Fang
Summary: In this study, an antibacterial and proangiogenic dressing is developed by encapsulating DMOG in ZIF-8 and electrospinning it with Gel-PCL. The dressing sequentially releases bactericidal zinc ions and angiogenic DMOG molecules, eliminating bacterial infection and promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaofeng Meng, Jingwei Guan, Shanshan Lai, Liming Fang, Jianyu Su
Summary: This paper reports a promising drug based on CCM incorporated into ZIF-8, which has high drug loading capability and drug release behavior, as well as excellent antibacterial activity. The experimental results suggest that ZIF@CCM can increase the permeability of bacterial cell membrane, thereby disrupting the bacterial cell membrane and achieving microbial inactivation.