Review
Chemistry, Medicinal
He Ma, Zhenxiang Pan, Bingjie Lai, Chunfang Zan, He Liu
Summary: From a clinical perspective, local anesthetics have widespread application in various medical procedures. However, traditional local anesthetic agents have limitations such as neurotoxicity and short duration of action. Nanotechnology-based drug delivery systems have emerged as a promising solution to enhance drug release and prolong the effects of local anesthetics with reduced systemic toxicity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Thermodynamics
Dorinel Okolisan, Titus Vlase, Gabriela Vlase, Ionela-Amalia Bradu, Claudiu Avram
Summary: A new type of polysaccharide film containing amide-type anesthetics was synthesized in this study. The stability of these films suggests their potential use as carriers for local anesthesia.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Review
Biochemistry & Molecular Biology
Liu Yu, Zewen Luo, Tian Chen, Yaqi Ouyang, Lingyun Xiao, Shu Liang, Zhangwen Peng, Yang Liu, Yang Deng
Summary: Localized drug delivery is an effective strategy for achieving direct and instant therapeutic effects. Bioadhesive nanoparticles (NPs) offer prolonged drug retention time and steadily maintained therapeutic concentrations, making them a promising carrier for optimized local drug delivery with abundant clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Zongyu Xie, Junjian Shen, Haitao Sun, Jingchao Li, Xiaojing Wang
Summary: Utilizing unique porous structures, hydrogels enable local delivery of drugs into tumors to trigger antitumor immunity at lower dosages. Polymer-based hydrogels serve as drug release systems for cancer immunotherapy, allowing for combination with chemotherapy and phototherapy for enhanced treatment efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Gustavo Henrique Rodrigues da Silva, Julia Borges Paes Lemes, Gabriela Geronimo, Fabiola Vieira de Carvalho, Talita Cesarim Mendonca, Kaue Franco Malange, Fernando Freitas de Lima, Marcia Cristina Breitkreitz, Carlos Amilcar Parada, Teresa Dalla Costa, Eneida de Paula
Summary: Unsuccessful anesthesia often occurs under an inflammatory tissue environment, making dentistry treatment extremely painful and challenging. By encapsulating Articaine (ATC) in nanostructured lipid carriers (NLCs), the pharmacokinetics and pharmacodynamics of the drug can be improved, thereby increasing its anesthetic effect on inflamed tissue.
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Analytical
Ajay Prabhakar Attiguppe, Dhiman Chatterjee, Amitava DasGupta
Summary: Transdermal drug delivery (TDD) has made significant progress in recent years, allowing targeted microdosing, bespoke treatment regimens, and improved drug adherence. The use of polymers in drug delivery is increasing due to their low cost, scalability, ease of manufacture, and compatibility. This study presents the design and development of a polymer-based TDD platform fabricated using additive manufacturing technologies, including a 3D-printed micropump, drug reservoir, and hollow microneedle array. This integrated system demonstrates efficient drug delivery with minimal moving parts and can be easily fabricated using additive manufacturing technologies.
Review
Oncology
Peng Xu, Shaobo Zhang, Lili Tan, Lei Wang, Zhongwei Yang, Jinbao Li
Summary: Despite advancements in cancer treatment, there is still a need for new anticancer drugs with new structures and mechanisms. Drug repurposing, specifically the use of approved drugs for new indications, offers a feasible strategy for discovering new drugs. Ropivacaine, a local anesthetic, has been found to inhibit cancer cells and enhance the effectiveness of chemotherapy drugs. It acts through multiple mechanisms and requires further research to understand its full potential.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Lauren J. Delaney, John R. Eisenbrey, David Brown, Jonathan R. Brody, Masaya Jimbo, Brian E. Oeffinger, Maria Stanczak, Flemming Forsberg, Ji-Bin Liu, Margaret A. Wheatley
Summary: Ultrasound imaging has many advantages, and the development of microbubble contrast agents presents new opportunities for drug delivery. Gemcitabine-loaded microbubbles show potential therapeutic effects for pancreatic cancer.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Joseph M. M. Laubach, Rajesh K. K. Sani
Summary: This study explores the use of a crude exopolysaccharide (EPS) extracted from cost-effective lignocellulosic biomass to construct a 5% amikacin-loaded film. The film was found to be non-cytotoxic to human keratinocytes and human skin-tissue fibroblasts, maintaining cell viability above 85% over 72 hours. The released amikacin from the EPS film exhibited significant growth inhibition against Staphylococcus aureus, maintaining above 91% inhibition for 48 hours.
Article
Nanoscience & Nanotechnology
Mozhdeh Ghani, Arto Heiskanen, Janko Kajtez, Babak Rezaei, Niels Bent Larsen, Peter Thomsen, Anders Kristensen, Airidas Zukauskas, Martin Alm, Jenny Emneus
Summary: This study presents a novel reversible switchable UV-triggered drug delivery system based on interpenetrating polymer networks, utilizing photo-responsive IPNs to provide a new concept for controlled drug release. The research investigates how copolymer composition and drug lipophilicity affect the release profile, and develops a thermodynamic model to optimize the polymer composition for efficient light-triggered drug release. The results demonstrate excellent light-triggered release for specific drugs and highlight the potential of the developed IPNs in drug delivery applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Zahra Ayar, Mehdi Shafieian, Narges Mahmoodi, Omid Sabzevari, Zahra Hassannejad
Summary: This study aimed to develop a drug delivery system using pNIPAM hydrogel and low molecular weight PEG200 solvent to enhance solubility and release of curcumin. Results showed that PEG200 increased curcumin solubility and had a significant effect on cumulative curcumin release compared to methanol. The combination of pNIPAM hydrogel and low molecular weight PEG200 can be an efficient drug delivery system for sustained release of curcumin.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Nurul Huda Kamsani, Muhammad Salahuddin Haris, Manisha Pandey, Muhammad Taher, Kamal Rullah
Summary: Electrospinning technique is a versatile method for producing continuous nanofibers, which has become cost-effective and drawn keen interests in the biomedical field. Smart electrospun pH-responsive nanofibers have various applications in emerging biomedical developments such as cancer drug targeting, wound healing, and vaginal drug delivery.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Elena Bellotti, Andrea L. Schilling, Steven R. Little, Paolo Decuzzi
Summary: The central nervous system (CNS) plays a crucial role in coordinating the activities of the whole body, and the societal and economic burden associated with CNS disorders continues to grow. The challenges in treating CNS disorders lie in the complexity of the disease mechanisms and unique biological microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Hai Yang, Ruyu Yan, Qiuyi Chen, Yanyan Wang, Xiupeng Zhong, Sa Liu, Renjian Xie, Li Ren
Summary: Local drug delivery through inter-articular injection using a modified nano-liposome drug carrier can restore lubrication and alleviate inflammation in osteoarthritis, providing a new approach for treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Likun Wang, Yuchen Zhou, Janis Timoshenko, Shizhong Liu, Qiao Qiao, Kim Kisslinger, Michael Cuiffo, Ya-Chen Chuang, Xianghao Zuo, Yuan Xue, Yichen Guo, Chen Pan, Hongfei Li, Chang-Yong Nam, Stoyan Bliznakov, Ping Liu, Anatoly I. Frenkel, Yimei Zhu, Miriam H. Rafailovich
Article
Engineering, Biomedical
Yang Zhou, Jinyi Tan, Jianfeng Wu, Qi Zhang, John Andre, Chuanwu Xi, Zhan Chen, Mark E. Meyerhoff
ACTA BIOMATERIALIA
(2019)
Review
Chemistry, Inorganic & Nuclear
Yingjie Yu, Quan Xu, Shasha He, Hejian Xiong, Qingfei Zhang, Weiguo Xu, Vincent Ricotta, Lei Bai, Qi Zhang, Zhiqiang Yu, Jianxun Ding, Haihua Xiao, Dongfang Zhou
COORDINATION CHEMISTRY REVIEWS
(2019)
Article
Polymer Science
Xianghao Zuo, Yuan Xue, Yuchen Zhou, Yifan Yin, Tai-De Li, Likun Wang, Ya-Chen Chuang, Chung-Chueh Chang, Miriam H. Rafailovich, Yichen Guo
Article
Energy & Fuels
Likun Wang, Stoyan Bliznakov, Rebecca Isseroff, Yuchen Zhou, Xianghao Zuo, Aniket Raut, Wanhua Wang, Michael Cuiffo, Taejin Kim, Miriam H. Rafailovich
Article
Nanoscience & Nanotechnology
Qi Zhang, Xuewei Wang, Vanessa Decker, Mark E. Meyerhoff
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Physical
Yuchen Zhou, Yifan Yin, Xianghao Zuo, Likun Wang, Tai-De Li, Yuanyuan Zhou, Nitin P. Padture, Zhenhua Yang, Yichen Guo, Yuan Xue, Kim Kisslinger, Mircea Cotlet, Chang-Yong Nam, Miriam H. Rafailovich
CHEMISTRY OF MATERIALS
(2020)
Article
Engineering, Multidisciplinary
Yichen Guo, Xianghao Zuo, Yuan Xue, Jinghan Tang, Michael Gouzman, Yiwei Fang, Yuchen Zhou, Likun Wang, Yingjie Yu, Miriam H. Rafailovich
COMPOSITES PART B-ENGINEERING
(2020)
Article
Materials Science, Composites
Yuval Shmueli, Yu-Chung Lin, Xianghao Zuo, Yichen Guo, Sungsik Lee, Guillaume Freychet, Mikhail Zhernenkov, Taejin Kim, Rina Tannenbaum, Gad Marom, Dilip Gersappe, Miriam H. Rafailovich
COMPOSITES SCIENCE AND TECHNOLOGY
(2020)
Article
Engineering, Multidisciplinary
Yuan Xue, Xianghao Zuo, Likun Wang, Yuchen Zhou, Yue Pan, Juyi Li, Yifan Yin, Dinghua Li, Rongjie Yang, Miriam H. Rafailovich, Yichen Guo
COMPOSITES PART B-ENGINEERING
(2020)
Article
Chemistry, Physical
Yuchen Zhou, Yifan Yin, Xianghao Zuo, Likun Wang, Tai-De Li, Yuan Xue, Ashwanth Subramanian, Yiwei Fang, Yichen Guo, Zhenhua Yang, Mircea Cotlet, Chang-Yong Nam, Miriam H. Rafailovich
Summary: The addition of a polystyrene-co-polyacrylonitrile (SAN) copolymer can significantly enhance the thermal stability of organic-inorganic hybrid perovskites (OIHPs) and improve the stability of perovskite solar cells (PSCs) by suppressing the migration of organic cations. The study shows that incorporating SAN within the perovskite layer leads to superior thermal stability compared to pure perovskite, with only a small decrease in power conversion efficiency even after continuous thermal aging. This research suggests a promising potential of using polymer grain encapsulation for enhancing thermal stability of OIHPs and their solar cell performance by suppressing the out-diffusion of cationic organic components.
CHEMISTRY OF MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Yu Zheng, Feihuang Deng, Bo Wang, Yue Wu, Qing Luo, Xianghao Zuo, Xin Liu, Lihua Cao, Min Li, Haohui Lu, Senping Cheng, Xiaoling Li
Summary: A extrusion-based 3D printer using Melt Extrusion Deposition (MED) 3D printing technology was developed for pharmaceutical applications, allowing for precise and versatile drug release characteristics in fabricated tablets. This technology offers a novel approach for efficient pharmaceutical product development, potentially impacting drug delivery and pharmaceutical product development.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Yuan Xue, Fan Yang, Juyi Li, Xianghao Zuo, Bole Pan, Mingkang Li, Lisa Quinto, Jalaj Mehta, Lauren Stiefel, Conor Kimmey, Yuval Eshed, Eyal Zussman, Marcia Simon, Miriam Rafailovich
Summary: The study developed a flame-resistant xanthan gum-based hydrogel formulation with improved thermal protective performance compared to commercial hydrogels, showing effectiveness in protecting skin and tissues from burning projectiles. The formulation utilizes biodegradable and environmentally friendly materials like XG, starch, and RDP, and involves endothermic reactions to produce a char layer for burn protection.
Article
Chemistry, Physical
Likun Wang, Xianghao Zuo, Aniket Raut, Rebecca Isseroff, Yuan Xue, Yuchen Zhou, Bhawan Sandhu, Tzipora Schein, Tatiana Zeliznyak, Priyanka Sharma, Sunil Sharma, Benjamin S. Hsiao, Miriam H. Rafailovich
SUSTAINABLE ENERGY & FUELS
(2019)