Article
Biophysics
Jie Zheng, Jingjing Bi, Wei Zhao, Muhammad Sohail, Ninghua Fu, Xing Zhang
Summary: In this study, a delivery system for heparin was developed using magnetic composite materials, allowing for controlled, sustained, and targeted release. The composite exhibited high loading capacity and magnetic targeting capability, reducing systemic adverse effects and displaying excellent anticoagulant features.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Mengru Cai, Boran Ni, Xueling Hu, Kaixin Wang, Dongge Yin, Gongsen Chen, Tingting Fu, Rongyue Zhu, Xiaoxv Dong, Changhai Qu, Xingbin Yin
Summary: This study successfully prepared MOFs-based nanoparticles as a drug delivery platform with fluorescence imaging capability. The nanoparticles showed potential for tumor microenvironment-responsive drug release and exhibited high antitumor activity in vitro experiments.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Medicinal
Michele Coluccia, Valeria Parisse, Paolo Guglielmi, Giuseppe Giannini, Daniela Secci
Summary: Metal-organic frameworks (MOFs) have attracted great interest for their potential applications in various fields, including anticancer therapy. The development of smart MOFs is particularly important, as they can release drugs under specific conditions, leading to improved treatment outcomes. The tumor microenvironment offers a promising platform for the design and construction of smart nanoparticles that can selectively release drugs in proximity to cancer cells or directly within the intracellular environment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge
Summary: pH-responsive nanoparticles based on modified hydroxyethyl starch have been developed as an effective drug delivery system for cancer chemotherapy. These nanoparticles can accumulate in tumors and selectively release drugs in the acidic microenvironment, providing a sustained release of the drug.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, Xuliang Guo
Summary: A triple-responsive metal-organic framework is designed to release photosensitizers under low oxygen, reactive oxygen species, and low pH conditions, enhancing the efficacy of photodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jie Li, Zhongshi Wang, Han Han, Zhonghua Xu, Shasha Li, Ying Zhu, Yuejian Chen, Liang Ge, Yuan Zhang
Summary: A novel injectable drug delivery platform using self-assembled peptide hydrogels as carrier materials was developed. The pH-responsive ionic-complementary octapeptide FOE allows for sustained drug release.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiao Fu, Guiqiang Zhang, Yulin Zhang, Haifeng Sun, Shuang Yang, Shilei Ni, Jiwei Cui
Summary: The study demonstrated the one-pot synthesis of poly(ethylene glycol) mediated ZIF-8 NPs for the co-delivery of an anticancer drug and a cell-penetrating peptide to improve therapeutic efficacy. These pH-responsive NPs showed stability at neutral pH and released the encapsulated drugs at acidic pH, enhancing their cytotoxicity. This strategy provides a new perspective for the design of drug delivery systems and offers more opportunities for biomedical applications.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Abhinav P. Acharya, Kutay B. Sezginel, Hannah P. Gideon, Ashlee C. Greene, Harrison D. Lawson, Sahil Inamdar, Ying Tang, Amy J. Fraser, Kush V. Patel, Chong Liu, Nathaniel L. Rosi, Stephen Y. Chan, JoAnne L. Flynn, Christopher E. Wilmer, Steven R. Little
Summary: This study proposes a new drug delivery system that utilizes a customized MOF material for simultaneous delivery of multiple drugs. Experimental results demonstrate the biological stability of the delivery system and its ability to effectively reduce bacterial and viral growth.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Roman A. A. Verkhovskii, Alexey N. N. Ivanov, Ekaterina V. V. Lengert, Ksenia A. A. Tulyakova, Natalia Yu. Shilyagina, Alexey V. V. Ermakov
Summary: The paradigm of drug delivery via particulate formulations enables overcoming limitations of traditional chemotherapeutic agents. Stimuli-responsive systems capable of controlled cargo release are widely accepted, with endogenous pH being the most common trigger. However, challenges such as accumulation in off-target tissues, immunogenicity, and complexity of drug delivery hinder the implementation of this idea. This article discusses fundamental strategies for pH-responsive drug delivery, limitations, main problems, weaknesses, and reasons for poor clinical results.
Article
Chemistry, Multidisciplinary
Jin Xu, Li Chen, Wen Shu, Fang-Zhong Zhang, Bao-Xuan Xie, Hai-Shuang Wang, Yu-Lin Wang, Rong-Guang Lin
Summary: In this study, a metal-organic framework UiO-66 with metal zirconium as the node was synthesized and anticancer drugs and a photosensitizer were encapsulated using a post-loading method. Surface modification increased the stability and biocompatibility of the nanomaterials. The drugs were effectively released in an acidic environment and laser irradiation induced apoptosis. The materials demonstrated a good combined effect of chemotherapy and photodynamic therapy.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Soheyla Karimi, Vahid Zeyni, Hassan Namazi
Summary: In this study, a drug delivery system based on metal-organic frameworks was synthesized, which exhibited antioxidant properties. The results showed that the system could control the release of drugs at different pH conditions and had significant toxicity to cancer cells. Moreover, this drug delivery system had excellent antioxidant activity and low hemolysis activity.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Kun Fan, Jian Li, Yongshan Xu, Cheng Fu, Yuan Chen, Chenyang Zhang, Guoqun Zhang, Jing Ma, Tianyou Zhai, Chengliang Wang
Summary: This study reports the synthesis of a three-dimensional coordination polymer with atomically precise structures. The material exhibits high conductivity and has potential applications as cathodes in sodium-ion batteries with high capacity, rate capability, and cyclability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Lei Ge, Chenyang Qiao, Yikai Tang, Xiaoke Zhang, Xiqun Jiang
Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.
Article
Chemistry, Physical
Mohammad Reza Saeb, Navid Rabiee, Masoud Mozafari, Ebrahim Mostafavi
Summary: Metal-organic frameworks (MOFs), especially nanoscale MOFs (NMOFs), show exceptional tailorable properties and high potential for carrying anticancer drugs. Compared to other delivery systems, NMOFs are more flexible, have higher biodegradability potential, and can be easily functionalized.
Article
Nanoscience & Nanotechnology
Shen-Zhen Ren, Bin Wang, Xiao-Hua Zhu, Dan Zhu, Ming Liu, Shu-Kai Li, Yu-Shun Yang, Zhong-Chang Wang, Hai-Liang Zhu
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Oncology
Ruo-Jun Man, Nasreen Jeelani, Chongchen Zhou, Yu-Shun Yang
Summary: This review focuses on the utilization of quinoline derivatives in medicinal chemistry for developing anti-cancer drugs, discussing representative drugs or candidates and their main mechanisms. It provides a comprehensive overview of the relationship between drugs within the same mechanism, with insights into future prospects. The review aims to assist researchers interested in discovering quinoline derivative anti-cancer agents by summarizing, discussing, and highlighting potential challenges in the field.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Li Fang, Xiang-Yang Zhang, Qing Yuan, Dong-Dong Li, Qing-Cai Jiao, Yu-Shun Yang, Hai-Liang Zhu
Article
Chemistry, Analytical
Zeng-Hui Yuan, Xu-Ping Zhang, Jing Guan, Li-Li Chen, Shu-Kai Li, Ming Liu, Ya-Juan Qin, Yu-Shun Yang, Hai-Liang Zhu
Article
Chemistry, Analytical
Zhen Li, Yan Li, Yushun Yang, Zhiyuan Gong, Hailiang Zhu, Yong Qian
ANALYTICA CHIMICA ACTA
(2020)
Article
Biochemistry & Molecular Biology
Peng-Fei Qi, Li Fang, Hua Li, Shu-Kai Li, Yu-Shun Yang, Jin-Liang Qi, Chen Xu, Hai-Liang Zhu
BIOORGANIC CHEMISTRY
(2020)
Review
Chemistry, Inorganic & Nuclear
Xiang-Yang Zhang, Yu-Shun Yang, Wei Wang, Qing-Cai Jiao, Hai-Liang Zhu
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Chemistry, Analytical
Qing Yuan, Li-Li Chen, Xiao-Hua Zhu, Zeng-Hui Yuan, Yong-Tao Duan, Yu-Shun Yang, Bao-Zhong Wang, Xiao-Ming Wang, Hai-Liang Zhu
Review
Cell Biology
Xiao-Hua Zhu, Jun-Xi Du, Dan Zhu, Shen-Zhen Ren, Kun Chen, Hai-Liang Zhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Biochemistry & Molecular Biology
Ruo-Jun Man, Xu-Ping Zhang, Yu-Shun Yang, Ai-Qin Jiang, Hai-Liang Zhu
Summary: In the past few decades, bacterial resistance has increased due to antibiotic abuse, leading to the discovery of super species of bacteria that threaten human health. Developing novel antibacterial agents to combat drug resistance is urgent. DNA gyrase, an essential enzyme for DNA replication and transcription, is a key target for bacterial inhibitors, with many inhibitors developed in recent years.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Jian-Fei Xu, Jin Gu, Ya-Lin Qi, Meng Zhang, Jian Chen, Dong-Dong Li, Yu-Shun Yang, Peng-Cheng Lv, Hai-Liang Zhu
Summary: The novel rotor P7-B with an improved auxochromic dynamic motor of azepanyl showed comparable targeting capability and better auxochroming potential for monitoring lysosomal viscosity. This work not only provides practical tools for lysosomal viscosity monitoring, but also significant information for transcending structural limits in future investigations.
Article
Chemistry, Analytical
Ya-Lin Qi, Hai-Rong Wang, Li-Li Chen, Bing Yang, Yu-Shun Yang, Zhen-Xiang He, Hai-Liang Zhu
Summary: A smart NIR fluorescent probe called VPCPP was proposed for monitoring microviscosity, micropolarity, and carboxylesterases in living cells. The probe was able to distinguish cancer cells and had the potential for various imaging applications. It was also utilized in high-throughput screening and imaging of inflammation models.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chaoyan Chen, Hao Chen, Yushun Yang, Hai-Liang Zhu
Summary: A novel probe with rapid response and high selectivity for thiophenol has been reported, enabling easy differentiation of thiophenol from other sulfur-containing species. The probe has been successfully used for the determination of thiophenol in various buffer systems and living cells, showing great potential for future applications.
ANALYTICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yu-Shun Yang, Bin Wang, Junzhong Liu, Qin Li, Qin-Cai Jiao, Pei Qin
Summary: In this study, a series of novel compounds Spartinin C1-C24 were screened, synthesized, and evaluated for their ability to inhibit xanthine oxidase and lower serum uric acid levels. The top hits, Spartinin C10 and C22, showed high inhibition percentages (78.54% and 93.74%) at a dosage of 10 μM, surpassing the positive control Allopurinol. They exhibited low cytotoxicity towards human normal hepatocyte cells. Spartinin C10 treatment effectively reduced serum uric acid levels in hyperuricemic model mice and showed comparable results to Allopurinol.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Qinglin Du, Xiangyang Zhang, Xinru Pan, Hongjuan Zhang, Yu-Shun Yang, Junzhong Liu, Qingcai Jiao
JOURNAL OF MOLECULAR STRUCTURE
(2020)