期刊
CELLS
卷 8, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells8020138
关键词
autophagy; innate immunity; adaptive immunity; modulators
类别
资金
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [NRF-2017R1C1B1006072]
- Main Research Program of the Korea Food Research Institute (KFRI) - Ministry of Science, ICT & Future Planning
Autophagy is an essential process that maintains physiological homeostasis by promoting the transfer of cytoplasmic constituents to autophagolysosomes for degradation. In immune cells, the autophagy pathway plays an additional role in facilitating proper immunological functions. Specifically, the autophagy pathway can participate in controlling key steps in innate and adaptive immunity. Accordingly, alterations in autophagy have been linked to inflammatory diseases and defective immune responses against pathogens. In this review, we discuss the various roles of autophagy signaling in coordinating immune responses and how these activities are connected to pathological conditions. We highlight the therapeutic potential of autophagy modulators that can impact immune responses and the mechanisms of action responsible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据