GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells Toward Breast Tumor Progression

Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion

(2018) Yu Ren et al.   Molecular Cancer

FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial–mesenchymal transition, and metastasis in FGFR1-amplified lung cancer

(2018) Kaixuan Wang et al.   ONCOGENE

Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

(2018) Navid Sobhani et al.   Cells

miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs)

(2018) Adele Vivacqua et al.   Cells

Tumor–Stroma Cross-Talk in Human Pancreatic Ductal Adenocarcinoma: A Focus on the Effect of the Extracellular Matrix on Tumor Cell Phenotype and Invasive Potential

(2018) Patrizia Procacci et al.   Cells

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

(2018) Bernhard Englinger et al.   Cells

Interaction between the estrogen receptor and fibroblast growth factor receptor pathways in non-small cell lung cancer

(2017) Jill M. Siegfried et al.   Oncotarget

Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis

(2017) Ruodan Xu et al.   Scientific Reports

FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)

(2016) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer

(2016) W. S. Brown et al.   MOLECULAR CANCER THERAPEUTICS

GPER, IGF-IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts

(2016) Assunta Pisano et al.   MOLECULAR CARCINOGENESIS

Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells

(2016) C. Huang et al.   NEUROSCIENCE

Dysregulated FGF signalling in neoplastic disorders

(2016) Yasmine Tanner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

(2016) James Campbell et al.   Cell Reports

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

(2016) Paola De Marco et al.   Scientific Reports

Estrogen receptor alpha and beta in health and disease

(2015) Min Jia et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Abstract 2435: FGFR1 is associated with resistance to interaction with estrogen receptor (ER) α endocrine therapy in ER+/FGFR1-amplified breast cancer

(2015) Luigi Formisano et al.   CANCER RESEARCH

Targeting FGFR Signaling in Cancer

(2015) M. Touat et al.   CLINICAL CANCER RESEARCH

The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis

(2015) Roberto Ronca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

(2015) Edward P. Carter et al.   TRENDS IN CELL BIOLOGY

Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts

(2015) Yali Han et al.   TUMOR BIOLOGY

SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer

(2015) M F Santolla et al.   Cell Death & Disease

Subtyping of triple-negative breast cancer: Implications for therapy

(2014) Vandana G. Abramson et al.   CANCER

GPER Mediates Activation of HIF1 /VEGF Signaling by Estrogens

(2014) E. M. De Francesco et al.   CANCER RESEARCH

Niacin activates the G protein estrogen receptor (GPER)-mediated signalling

(2014) Maria Francesca Santolla et al.   CELLULAR SIGNALLING

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

(2014) M. W. Wynes et al.   CLINICAL CANCER RESEARCH

Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion

(2014) S. J. Coleman et al.   EMBO Molecular Medicine

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy

(2014) Alexey Goltsov et al.   Cells

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives

(2013) Maria Vittoria Dieci et al.   Cancer Discovery

Fibroblasts as architects of cancer pathogenesis

(2012) Timothy Marsh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells

(2012) R. Lappano et al.   CURRENT CANCER DRUG TARGETS

CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling

(2012) Eriko Aoyama et al.   FEBS LETTERS

Epithelial Plasticity, Cancer Stem Cells, and the Tumor-Supportive Stroma in Bladder Carcinoma

(2012) G. van der Horst et al.   MOLECULAR CANCER RESEARCH

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Discordant Cellular Response to Presurgical Letrozole in Bilateral Synchronous ER+ Breast Cancers with a KRAS Mutation or FGFR1 Gene Amplification

(2012) J. M. Balko et al.   MOLECULAR CANCER THERAPEUTICS

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Insulin-like growth factor-I regulates GPER expression and function in cancer cells

(2012) P De Marco et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo

(2011) Rachel Sharpe et al.   CLINICAL CANCER RESEARCH

Metastasis: new perspectives on an old problem

(2011) Sandra Kraljevic Pavelic et al.   Molecular Cancer

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

(2010) C. M. Fillmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connective tissue growth factor: Context-dependent functions and mechanisms of regulation

(2009) Iwona Cicha et al.   BIOFACTORS

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

(2009) Deo Prakash Pandey et al.   EMBO JOURNAL

Estrogen-Related Cancer Microenvironment of Breast Carcinoma

(2009) Yuri YAMAGUCHI et al.   ENDOCRINE JOURNAL

Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis

(2009) Sonoko Chujo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The unfolding stories of GPR30, a new membrane-bound estrogen receptor

(2009) Marcello Maggiolini et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of estrogen signaling and gene expression via GPR30

(2009) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

Segregation and activation of myosin IIB creates a rear in migrating cells

(2008) Miguel Vicente-Manzanares et al.   JOURNAL OF CELL BIOLOGY

Drug-sensitive FGFR2 mutations in endometrial carcinoma

(2008) A. Dutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA