Article
Ophthalmology
Fumika Watanabe-Kitamura, Akiko Ogawa, Tomokazu Fujimoto, Satoshi Iraha, Miyuki Inoue-Mochita, Takahiro Watanabe, Eri Takahashi, Hidenobu Tanihara, Toshihiro Inoue
Summary: The roles of interleukin (IL)-6 family members during the wound healing process after glaucoma filtration surgery (GFS) were investigated. IL-6 and OSM may aid in controlling the phase transition from inflammation to proliferation and remodeling after GFS, by suppressing late response genes at the surgical site.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Oncology
Silu Wang, Linyong Du, Hao Chen, Xing Zhang, Bicheng Chen, Lihong Yang
Summary: In pancreatic cancer patients, high levels of the cytokine IL-6 were found in the blood serum, while pancreatic cancer cells themselves exhibited low expression of IL-6. The study uncovered the key role of the Jagged/Notch/IL-6/STAT3 positive feedback loop in the development of a hypercoagulable state in pancreatic cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Lara Magni, Rayhana Bouazzi, Hugo Heredero Olmedilla, Patricia S. S. Petersen, Marco Tozzi, Ivana Novak
Summary: The study reveals an important interaction between PSCs and cancer cells, involving ATP and IL-6 as key players, which activate P2X7 and IL-6 receptors, respectively, potentially serving as therapeutic targets for PDAC.
Article
Oncology
Junya Okabe, Takahiro Kodama, Yu Sato, Satoshi Shigeno, Takayuki Matsumae, Kazuma Daiku, Katsuhiko Sato, Teppei Yoshioka, Minoru Shigekawa, Masaya Higashiguchi, Shogo Kobayashi, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Takashi Satoh, Hidetoshi Eguchi, Shizuo Akira, Tetsuo Takehara
Summary: This study reveals that downregulation of Regnase-1 induced by IL-1 beta promotes pancreatic cancer by inducing MDSCs and evading anticancer immunity.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Woosol Chris Hong, Da Eun Lee, Hyeon Woong Kang, Myeong Jin Kim, Minsoo Kim, Ju Hyun Kim, Sungsoon Fang, Hyo Jung Kim, Joon Seong Park
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer and the role of CD74 in PDAC is not well understood. Silencing CD74 in the pancreatic cancer cell line Capan-1 led to reduced cell proliferation, migration, invasion, increased apoptosis, and decreased expression and secretion of S100A8 and S100A9. The study suggests that CD74 may serve as a potential diagnostic biomarker and therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Adam S. Bryce, Stephan B. Dreyer, Fieke E. M. Froeling, David K. Chang
Summary: This article discusses the heterogeneity of cancer-associated fibroblasts (CAFs) and their role in the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Molecular profiling allows for a better understanding of the characteristics of CAFs in the PDAC tumor microenvironment. The article also explores the complex relationship between CAFs and other cell types within the PDAC microenvironment, as well as the potential for therapeutic targeting of CAFs.
Review
Biochemistry & Molecular Biology
Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen, Frank Tacke
Summary: Fibrosis, a pathological scar tissue formation, can occur in various organs due to different etiologies and contributes to global morbidity and mortality. Common mechanisms involve sustained injury to parenchymal cells triggering a deregulated wound healing response. The transformation of fibroblasts into myofibroblasts with excessive extracellular matrix production is a hallmark of the disease, along with complex cellular interactions involving immune cells, endothelial cells, and parenchymal cells. Mediators such as growth factors, cytokines, and danger-associated molecular patterns play important roles in fibrosis across organs.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku
Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Raphael Peiffer, Yasmine Boumahd, Charlotte Gullo, Rebekah Crake, Elisabeth Letellier, Akeila Bellahcene, Olivier Peulen
Summary: Cancer-associated fibroblasts (CAFs) play a critical role in pancreatic cancer by influencing cancer cell metabolism through various mechanisms. CAF heterogeneity is characteristic of the pancreatic tumor microenvironment. Environmental changes in pH, oxygenation, and nutrient availability are heavily driven by stromal CAFs. The bidirectional crosstalk between CAFs and cancer cells promotes tumor aggressiveness and adaptation to external stress. This review summarizes the diversity of CAF subtypes, the metabolic crosstalk between CAFs and tumor cells, and the role of CAF-driven signaling, desmoplasia, and acidosis in cancer cell metabolism, highlighting potential therapeutic strategies.
Review
Pharmacology & Pharmacy
David Dolivo, Pamela Weathers, Tanja Dominko
Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Cell Biology
Laxmansa C. Katwa, Chelsea Mendoza, Madison Clements
Summary: Cardiovascular disease is the leading cause of death worldwide, and patients with cardiovascular diseases are more susceptible to severe complications of COVID-19. The role of cardiac myofibroblasts in both COVID-19-induced cardiac injury and healing process is crucial.
Article
Pharmacology & Pharmacy
Eigo Ikushima, Shin Ishikane, Takehiro Kishigami, Hiroaki Matsunaga, Kazunobu Igawa, Katsuhiko Tomooka, Yosuke Nishimura, Fumi Takahashi-Yanaga
Summary: 2,5-dimethylcelecoxib (DM-C) attenuates fibroblast-to-myofibroblast transformation (FMT) and decreases cardiac fibrosis by inhibiting the TGF-beta signaling pathway through activation of GSK-3.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Yongde Luo, Xiaokun Li, Jianjia Ma, James L. Abbruzzese, Weiqin Lu
Summary: Mutant KRAS is a key driver of pancreatic cancer, but its activity is regulated by upstream stimuli. Obesity exacerbates mutant KRAS-mediated pathologies, but the mechanistic link between obesity and pancreatic cancer remains unclear.
Article
Cell Biology
Michael P. Czubryt, Taben M. Hale
Summary: Cardiac fibrosis is a characteristic of end-stage heart disease, but there are no approved therapies directly targeting the extracellular matrix. Research on cardiac fibroblasts is hindered by the lack of a clear marker.
CELLULAR SIGNALLING
(2021)
Article
Agriculture, Dairy & Animal Science
Philipe Pimenta Nunes, Telma da Mata Martins, Ana Carolina Leite, Eliane Beatriz Magalhaes Silva, Tatiane Alves da Paixao, Renato Lima Santos, Alan Maia Borges
Summary: This study showed that endometrial samples from crossbred Zebu-based heifers during diestrous can produce IL-1 beta, IL-6, and CXCL8 in response to LPS and IL-1 beta in response to PGN. The cytokine production in response to LPS is not affected by the stage of the estrous cycle in Bos indicus crossbred heifers.
ANIMAL REPRODUCTION SCIENCE
(2021)