期刊
NATURE REVIEWS MATERIALS
卷 4, 期 2, 页码 134-145出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41578-018-0079-7
关键词
-
资金
- US National Institutes of Health [NIH R01-EB017755]
- US National Science Foundation award NSFCareer [PHY-1454673]
- Materials Research Science and Engineering Centers (MRSEC) Program of the US National Science Foundation [DMR-14-19807]
- US National Science Foundation Graduate Research Fellowship Program [1122374]
Mucus is a 3D hydrogel that houses the majority of the human microbiome. The mucous environment plays an important role in the differentiation and behaviour of microbial phenotypes and enables the creation of spatial distributions. Dysregulation of mucus is further associated with various diseases. Therefore, mucus is the key ingredient to study the behaviour of commensal and pathogenic microbiota in vitro. Indeed, microorganisms cultured in mucus exhibit phenotypes substantially different from those exhibited in standard laboratory media. In this Review, we discuss the impact of mucus on the microbiome and examine the structure and glycosylation of mucins - the main building blocks of mucus. We investigate the impact of glycans on mucin function and highlight different approaches for the engineering of synthetic mucins, including synthesis of the backbone, the design of mucin-mimetic hydrogels and the engineering of glycans. Finally, mucin mimetics for 3D in vitro cell culture and for modulating microbial community structure and function are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据