期刊
ROYAL SOCIETY OPEN SCIENCE
卷 6, 期 1, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsos.181557
关键词
carbon dots; Fe3+ ion; ascorbic acid; probe; biological samples
资金
- Natural Science Foundation of Hubei Province of China [2018CFC869]
- Natural Science Foundation of Hubei Provincial Department of Education [B2018112, Q20132102]
- Foundation for Fostering the National Natural Science Foundation of Hubei University of Medicine [2013GPY02]
- Initial Project for Post-Graduates of Hubei University of Medicine [2011QDZR-4]
A facile one-step hydrothermal synthesis approach was proposed to prepare nitrogen and chlorine co-doped carbon dots (CDs) using L-ornithine hydrochloride as the sole precursor. The configuration and component of CDs were characterized by transmission electron microscopy and X-ray photoelectron and Fourier transform infrared spectroscopies. The obtained CDs (Orn-CDs) with a mean diameter of 2.1 nm were well monodispersed in aqueous solutions. The as-prepared CDs exhibited a bright blue fluorescence with a high yield of 60%, good photostability and low cytotoxicity. The emission of Orn-CDs could be selectively and effectively suppressed by Fe3+. Thus, a quantitative assay of Fe3+ was realized by this nanoprobe with a detection limit of 95.6 nmol l(-1) in the range of 0.3-50 mu mol l(-1). Furthermore, ascorbic acid could recover the fluorescence of Orn-CDs suppressed by Fe3+, owing to the transformation of Fe3+ to Fe2+ by ascorbic acid. The limit of detection for ascorbic acid was 137 nmol l(-1) in the range of 0.5-10 mu mol l(-1). In addition, the established method was successfully applied for Fe3+ and ascorbic acid sensing in human serum and urine specimens and for imaging of Fe3+ in living cells. Orn-CD-based sensing platform showed its potential to be used for biomedicine-related study because it is cost-effective, easily scalable and can be used without additional functionalization and sample pre-treatment.
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