Review
Biochemistry & Molecular Biology
Monika Kowalczyk, Jakub P. P. Piwowarski, Artur Wardaszka, Paulina Srednicka, Michal Wojcicki, Edyta Juszczuk-Kubiak
Summary: Obesogenic endocrine-disrupting chemicals (EDCs), found in environmental contaminants, can contribute to a rapid increase in obesity through chronic exposure. These chemicals are commonly found in widely used industrial products such as plasticizers, flame retardants, and pesticides. The main source of exposure to obesogenic EDCs is through the consumption of contaminated food. EDCs promote obesity by affecting adipocytes and hepatocytes, disrupting glucose metabolism and insulin secretion, and impacting hormonal appetite/satiety regulation. In vitro models are important tools for studying the mechanisms of obesogenic action of industrial chemicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Nicole Mohajer, Chrislyn Y. Du, Christian Checkcinco, Bruce Blumberg
Summary: The rising rates of obesity and related metabolic diseases are demanding increasing attention on chemical screening efforts and worldwide preventative strategies. Obesogens, a subset of endocrine disrupting chemicals (EDCs), can affect the metabolic system through multiple pathways. Their impact on systems such as the gut microbiome and brown adipose tissue needs to be carefully studied.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Angelica Amorim Amato, Hailey Brit Wheeler, Bruce Blumberg
Summary: Obesity has become a global pandemic, with traditional explanations pointing to high-calorie diets and lack of exercise. However, the presence of endocrine-disrupting chemicals (EDCs) in the environment may also be a significant factor contributing to the increasing rates of obesity worldwide.
ENDOCRINE CONNECTIONS
(2021)
Review
Pharmacology & Pharmacy
Akhgar Ghassabian, Laura Vandenberg, Kurunthachalam Kannan, Leonardo Trasande
Summary: This article discusses the unique vulnerability of children to endocrine-disrupting chemicals (EDCs) and the programming effects of EDCs on neuronal, metabolic, immune, endocrine, reproductive, and renal systems. By dispelling myths and providing a list of actions to reduce exposure and harm, it aims to address the health effects of EDCs on child health.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
V. L. Marlatt, S. Bayen, D. Castaneda-Cortes, G. Delbes, P. Grigorova, V. S. Langlois, C. J. Martyniuk, C. D. Metcalfe, L. Parent, A. Rwigemera, P. Thomson, G. Van der Kraak
Summary: This review summarizes the current knowledge of the impacts of EDCs on reproductive success in wildlife and humans, with a focus on retrospective assessment and laboratory-based experiments. The evidence suggests that anthropogenic chemicals negatively impact reproduction by altering endocrine system function, particularly in aquatic species. Similar effects are observed in mammalian wildlife and humans in epidemiological studies. Further research is needed on the implications of chemical exposures during development and the potential for long-term reproductive effects. Field-based observations and long-term population level studies are key to addressing knowledge gaps.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Katherine Svensson, Chris Gennings, Christian Lindh, Hannu Kiviranta, Panu Rantakokko, Sverre Wikstrom, Carl-Gustaf Bornehag
Summary: This study found an association between prenatal exposure to a mixture of EDCs and lower BMI and overweight in girls, with non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Emily N. Hilz, Andrea C. Gore
Summary: Exposure to endocrine-disrupting chemicals (EDCs) during developmental periods can lead to sex-specific changes in the brain's monoaminergic systems (dopamine, serotonin, norepinephrine), potentially affecting cognition such as affective, attentional, and learning/memory behaviors.
Review
Biotechnology & Applied Microbiology
Muhammad Musaddiq Shah, Khurshid Ahmad, Sonia Boota, Tor Jensen, Michael R. La Frano, Joseph Irudayaraj
Summary: Endocrine-disrupting chemicals (EDCs) are man-made substances that can disrupt the standard function of the endocrine system. They are widespread in the environment and pose a potential threat to human health, aquatics, and wildlife. Traditional instrument-based analytical techniques are not suitable for onsite detection, while sensor/biosensor-based approaches are more attractive due to their rapid, portable, equally sensitive, and eco-friendly characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Yingji Wu, Yubo Liu, Hesam Kamyab, Manivasagan Rajasimman, Natarajan Rajamohan, Gia Huy Ngo, Changlei Xia
Summary: Due to their harmful effects on human health and the environment, there is significant concern regarding the widespread occurrence of endocrine-disrupting hazardous chemicals (EDHCs). To address this concern, various physicochemical and biological remediation techniques have been developed. This review paper provides a comprehensive overview of the state-of-the-art remediation techniques for eliminating EDHCs, including adsorption, membrane filtration, photocatalysis, biodegradation, phytoremediation, and microbial fuel cells. The review discusses the effectiveness, advantages, limitations, and factors affecting the performance of each technique, as well as recent developments and future perspectives in EDHCs remediation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Mohd Faiz Muaz Ahmad Zamri, Raihana Bahru, Fatihah Suja, Abd Halim Shamsuddin, Sagor Kumar Pramanik, Islam Md Rizwanul Fattah
Summary: This article discusses treatment strategies for the removal of endocrine-disrupting chemicals (EDC) in water and wastewater systems, including physical, biological, and chemical treatments, as well as integrated approaches. The effectiveness of membrane filtration as a physical method for EDC removal is highlighted, along with the limitations and challenges of various treatment methods.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Review
Endocrinology & Metabolism
Tim Lobstein, Kelly D. Brownell
Summary: Emerging evidence suggests that industrially produced endocrine-disrupting chemicals may contribute to obesity, and should be considered in obesity prevention policies. However, current policy documents have limited content on the control and avoidance of exposure to EDCs.
Article
Biochemistry & Molecular Biology
Reinaldo Sousa Dos Santos, Regla Maria Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Summary: Identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity are necessary. This study used various cell lines to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). Results suggest that one chemical could be a new diabetogenic agent, and the EndoC-beta H1 cell line is a suitable human beta-cell model for testing diabetogenic MDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)