Article
Endocrinology & Metabolism
Wei Zhang, Jun Zheng, Jikun Zhang, Ninghua Li, Xilin Yang, Zhong-Ze Fang, Qiang Zhang
Summary: In Chinese patients with type 2 diabetes mellitus (T2DM), high serum citrulline and low ornithine/citrulline ratio are associated with increased risk of chronic kidney disease (CKD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tie Li, Hui-Huan Luo, Xiao-Fei Feng, Yu Bai, Zhong-Ze Fang, Gui-Gang Wu, Jian-Lin Wu
Summary: This study found that elevated factor 3 composed of glutamate and tryptophan in plasma free amino acids was associated with increased risk of cardiovascular disease, especially stroke, in Chinese with Type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Wei-Ming Luo, Zhi-Peng Zhang, Wei Zhang, Jing-Yang Su, Xiao-Qian Gao, Xu Liu, Wan-Ying Wang, Chang-Tao Jiang, Zhong-Ze Fang
Summary: The study found a U-shaped curve relationship between homocysteine and diabetic retinopathy, with the homocysteine pathway having an impact on this relationship. A low concentration of homocysteine indicates a lack of other substances.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Abdelrahim Alqudah, Mohammed Wedyan, Esam Qnais, Hassan Jawarneh, Lana McClements
Summary: The study found changes in the levels of certain amino acids in patients with type 2 diabetes, with some essential amino acids increased and some non-essential amino acids decreased. These amino acids were shown to be correlated with the patients' blood glucose and HbA1c levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Beatrice Foglia, Marc Beltra, Salvatore Sutti, Stefania Cannito
Summary: Hepatocellular carcinoma (HCC) is a common primary liver cancer, ranking third in cancer-related mortality worldwide. Metabolic rewiring has emerged as a key factor in HCC progression, affecting cancer cell behavior and immune responses. This review focuses on recent studies exploring HCC's metabolic traits, specifically alterations in glucose, fatty acid, and amino acid metabolism. Additionally, it examines how metabolic reprogramming can impact the tumor microenvironment and immune cell populations, enabling tumor escape from immunosurveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Huanhuan Zhu, Mengqiu Bai, Xishao Xie, Junni Wang, Chunhua Weng, Huifen Dai, Jianghua Chen, Fei Han, Weiqiang Lin
Summary: This study aimed to reveal the metabolomic signatures in diabetes development and progression by comparing metabolite changes among healthy individuals, type 2 diabetes mellitus patients, and diabetic kidney disease patients. It was found that impaired amino acid metabolism was the main metabolic signature in diabetes, and specific metabolites were associated with the development of diabetic kidney disease.
Article
Multidisciplinary Sciences
Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia, Tineke van de Weijer, Joris Hoeks, Vera B. Schrauwen-Hinderling, Megan C. Blair, Marc R. Bornstein, Matthijs K. C. Hesselink, Patrick Schrauwen, Zoltan Arany, Esther Phielix
Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Wanglong Gou, Chu-wen Ling, Yan He, Zengliang Jiang, Yuanqing Fu, Fengzhe Xu, Zelei Miao, Ting-yu Sun, Jie-sheng Lin, Hui-lian Zhu, Hongwei Zhou, Yu-ming Chen, Ju-Sheng Zheng
Summary: Our study identified core gut microbial features associated with type 2 diabetes risk and future glucose increment using an interpretable machine learning framework. We also confirmed the relationship between these features and type 2 diabetes through human fecal sample transplantation to germ-free mice. Additionally, we found body fat distribution to be a key factor modulating the gut microbiome-type 2 diabetes relationship.
Review
Biochemistry & Molecular Biology
Yinli Huang, Jiahui Lu, Qihui Zhao, Junli Chen, Wei Dong, Minjie Lin, Hong Zheng
Summary: This review discusses the application of NMR-based metabolomics in diabetic therapy using traditional Chinese medicine (TCM), providing insights into the metabolic mechanisms affected by TCM treatment.
Article
Chemistry, Analytical
Lili Zhang, Yifan Zhang, Zhihui Ma, Yanrong Zhu, Zhong Chen
Summary: This study identified significant metabolic differences in patients with both coronary heart disease (CHD) and type 2 diabetes (T2D), including alterations in branched-chain amino acids (BCAAs) and phenylalanine. These findings suggest that altered cardiac energy metabolism and activated signaling pathway may be potential therapeutic targets for individuals with CHD and T2D.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Aysim Gunes, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Akerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Soren Brunak, Marko Barovic, Gerard A. Bouland, Frederic Burdet, Mickael Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M't Hart, Ewan R. Pearson, Guy A. Rutter
Summary: We identified biomarkers for disease progression in type 2 diabetes cohorts, including metabolites, lipids, and proteins. Various substances such as homocitrulline, isoleucine, 2-aminoadipic acid, triacylglycerol species, and sphingomyelin 42:2;2 levels were found to predict faster progression towards insulin requirement. Proteins like GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 were associated with faster progression, while others like SMAC/DIABLO, SPOCK1, and HEMK2 predicted slower progression rates. The findings also suggested possible disease mechanisms and potential therapeutic avenues to slow diabetes progression.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Penglong Cao, Bing Huang, Mo Hong, Yuxin Jiang, Ran Cao, Chen Chi, Yunfeng Cao, Shijun Li
Summary: Citrulline was consistently associated with diabetic nephropathy risk in two independent cross-sectional studies among Chinese adults, while ornithine, arginine, and the ratio of arginine to ornithine showed no significant association with diabetic nephropathy risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Guoying Wang, Jessie P. Buckley, Tami R. Bartell, Xiumei Hong, Colleen Pearson, Xiaobin Wang
Summary: The study aimed to identify a lipidomic signature associated with gestational diabetes mellitus (GDM) in the postpartum period and investigate its role in the progression to type 2 diabetes (T2D). A cohort of 1,409 women who delivered a singleton baby was followed up prospectively, and their lipidome was analyzed using liquid chromatography-tandem mass spectrometry. 33 postpartum lipid species were identified to be associated with GDM, and 4 of them were also associated with incident T2D, mediating the progression from GDM to T2D. Including these lipid species improved the prediction of T2D when considering the entire follow-up period.
Article
Environmental Sciences
Guozhu Ye, Xu Zhang, Xinyu Liu, Xu Liao, Han Zhang, Changzhou Yan, Yi Lin, Qiansheng Huang
Summary: The study found that exposure to polystyrene microplastics significantly altered the metabolism of marine medaka livers, leading to changes in various metabolic pathways and levels of specific metabolites. The effects of different sizes of microplastics (10-mu m and 200-mu m) on hepatic metabolism were observed, with differences in the impact on carbohydrate, amino acid, and lipid metabolism. Overall, the results provide new insights into the ecotoxicology of microplastics in aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)