Review
Cell Biology
Dongmei Fang, Huazhong Xie, Tao Hu, Hao Shan, Min Li
Summary: ATG3 plays a crucial role in autophagosome formation, contributing to various physiological and pathological processes such as tumor progression, ischemia-reperfusion injury, and organelle homeostasis. Additionally, ATG3 has been found to have autophagy-independent functions, including roles in cell differentiation and mitosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhaolong Peng, Daofei Ji, Lukuan Qiao, Yuedong Chen, Hongjuan Huang
Summary: The upregulation of ATG3 in CI/R injury promotes autophagy in brain microvascular endothelial cells, leading to cell damage and inflammation. Inhibiting autophagy by interference of ATG3 can alleviate OGD/R-induced injury and inflammation through activation of the PI3K/Akt pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Oncology
Fatima Baker, Ibrahim H. Polat, Khalil Abou-El-Ardat, Islam Alshamleh, Marlyn Thoelken, Daniel Hymon, Andrea Gubas, Sebastian E. Koschade, Jonas B. Vischedyk, Manuel Kaulich, Harald Schwalbe, Shabnam Shaid, Christian H. Brandts
Summary: Autophagy plays a crucial role in leukemia progression and survival, with the loss of ATG3 leading to increased glycolysis and mitochondrial metabolism in leukemia cells to maintain cell survival. Targeting both autophagy and mitochondrial metabolism may be a promising approach for overcoming potential resistance in leukemia therapy.
Review
Oncology
Xiaokun Ji, Hua Ma, Yun Du
Summary: LAPTM4B, upregulated in various cancers, is associated with cancer cell proliferation, survival, drug resistance, and poor patient prognosis. It may promote cancer cell proliferation through blocking EGFR signal transduction and activating the PI3K/AKT pathway, and may be involved in autophagy through the EGFR signaling pathway.
Article
Cell Biology
Gal Chaim Nuta, Yuval Gilad, Nadav Goldberg, Sara Meril, Marcela Bahlsen, Silvia Carvalho, Noga Kozer, Haim Barr, Yael Fridmann Sirkis, Kamil Hercik, Petra Brehova, Radim Nencka, Shani Bialik, Miriam Eisenstein, Adi Kimchi
Summary: Autophagy is a process of cellular content degradation and recycling, which has been found to play a crucial role in advanced stages of cancer by maintaining tumor cell homeostasis and promoting continuous growth under hypoxic or nutrient-starved conditions. Autophagy also supports alternative cellular trafficking pathways and provides a mechanism for the non-canonical secretion of inflammatory cytokines. This opens up potential therapeutic opportunities for using autophagy inhibitors in cancer treatment and acute inflammatory responses.
Editorial Material
Cell Biology
Mohyeddine Omrane, Thomas J. Melia, Abdou Rachid Thiam
Summary: Macroautophagy/autophagy and lipid droplet (LD) biology are closely related, with autophagosome-dependent degradation of LDs in response to different signals. LDs play crucial roles in forming autophagosomes by providing lipids and serving as a supportive autophagosome assembly platform. ATG3 localizes to large LDs during prolonged starvation, lipidating LC3B and revealing a non-canonical autophagic role on LDs.
Article
Fisheries
Hongyan Yu, Xuewen Jia, Huiqin Niu, Lingli Xie, Biao Du, Yifan Pang, Xiaoyan Xu, Jiale Li
Summary: miRNAs have a key role in the autophagy process and have been found to indirectly modulate immune function. This study confirmed that miR-23a can simultaneously down-regulate autophagy in grass carp by targeting ATG3 and ATG12. Additionally, it was found that miR-23a levels decreased while ATG3 and ATG12 mRNA levels increased in kidney and intestine after infection by Aeromonas hydrophila. Furthermore, miR-23a was found to affect various immune functions in grass carp, including antimicrobial capacity and cellular activities. These findings provide important insights into the role of autophagy-related miRNAs in teleost defense and immune mechanisms against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
You Zhou, Yingjie Shao, Wenwei Hu, Jinping Zhang, Yufang Shi, Xiangyin Kong, Jingting Jiang
Summary: The SP100-AS1/miR-622/ATG3 axis plays a crucial role in radioresistance and autophagic activity in colorectal cancer, indicating its potential as a therapeutic target to improve the response to radiation therapy.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Physiology
Anna Santos, Isabela Ramos
Summary: The study revealed that ATG3 is highly expressed in the ovaries of the insect Rhodnius prolixus and its depletion leads to a decrease in oviposition rates and the production of unviable eggs. Furthermore, eggs depleted of ATG3 exhibit altered chorion ultrastructure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
He Wang, Qibo Wang, Yaoyao Wu, Jianmin Lou, Shaoxing Zhu, Yipeng Xu
Summary: Renal cell carcinoma (RCC) is a common urologic disease that is primarily treated with surgery. Recent studies have shown that autophagy affects the immune environment of RCC and promotes cancer cell proliferation and apoptosis. LAPTM4B is an autophagy-related gene that is significantly associated with M2 macrophage increase in the immune microenvironment of RCC patients. Downregulation of LAPTM4B expression reduces RCC cell proliferation and promotes apoptosis, suggesting LAPTM4B as a potential therapeutic target for RCC immunotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Ruyu Yan, Dan Liu, Junjie Wang, Minxia Liu, Hongjuan Guo, Jing Bai, Shuo Yang, Jun Chang, Zhihong Yao, Zuozhang Yang, Tomas Blom, Kecheng Zhou
Summary: Osteosarcoma (OS) is a rare malignant bone tumor and a leading cause of cancer mortality in childhood and adolescence. The cytoskeleton plays a critical role in cell motility, migration, and cancer metastasis. We found that LAPTM4B is highly expressed in OS and regulates stress fiber organization through the RhoA-LIMK-cofilin signaling pathway. Furthermore, we revealed that miR-137 targets LAPTM4B and regulates stress fiber arrangement, OS cell migration, and metastasis. This study suggests that the miR-137-LAPTM4B axis is a promising therapeutic target for OS.
Article
Entomology
Dandan Liu, Zhengxi Li, Maolin Hou
Summary: Plant viruses are often spread by insects, such as the southern rice black-streaked dwarf virus which is exclusively transmitted by the planthopper, Sogatella furcifera. Autophagy, a cellular survival response, may be triggered by virus invasion in the insect vector and can either suppress or promote virus propagation and transmission. This study found that autophagy-related genes, SfATG3 and SfATG9, are conserved in various insects and their expression is activated in the planthopper vector after exposure to the virus. Silencing these genes promoted the virus's propagation and transmission.
Article
Multidisciplinary Sciences
Minsu Jang, Rackhyun Park, Ayane Yamamoto, Yea-In Park, Yeonjeong Park, Siyun Lee, Junsoo Park
Summary: A study has found that an inhibitor called compound C can effectively inhibit the replication of the human coronavirus OC43 strain. This finding suggests that compound C may be a potential drug candidate for COVID-19.
Article
Biochemistry & Molecular Biology
Mina Jang, Shuta Hara, Gun-Hee Kim, Seung Min Kim, Sangkeun Son, Mincheol Kwon, In-Ja Ryoo, Hyemin Seo, Min Jung Kim, Nam-Doo Kim, Nak-Kyun Soung, Yong Tae Kwon, Bo Yeon Kim, Hiroyuki Osada, Jae-Hyuk Jang, Sung-Kyun Ko, Jong Seog Ahn
Summary: The study demonstrates a novel autophagy enhancer, dutomycin (DTM), that induces autophagy and eventually apoptosis by activating serine protease inhibitor B6 (SERPINB6). The inhibitory effects of DTM on SERPINB6 function were confirmed, and this research provides new insights for future studies on the relationship between cancer and autophagy.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yen-Tze Liu, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Platyphyllenone can induce both autophagy and apoptosis in oral cancer cells by regulating multiple signaling pathways, providing a potential therapeutic option for chemoprevention against oral cancer proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Qiaoyu Chen, Dongbing Tong, Wuneng Zhou, Yuhua Xu, Jinping Mou
Summary: This study designs a new sliding mode controller to ensure the exponential stability of stochastic neutral-type systems with Markovian switching and Levy noises, and proposes a corresponding exponential stability criterion.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2021)
Article
Automation & Control Systems
Yu Rao, Dongbing Tong, Qiaoyu Chen, Wuneng Zhou, Yuhua Xu
Summary: The paper studies the asymptotic stability of chaotic Lur'e systems (CLSs) and presents a new control method involving both state and control quantizers. The dynamic parameters of quantizers and controller are designed synchronously to ensure system synchronization, and can be obtained by solving linear matrix inequalities. Numerical simulation and practical simulations are used to validate the effectiveness of the control strategy.
TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
(2021)
Article
Engineering, Electrical & Electronic
Yuhua Xu, Xiaoqun Wu, Bing Mao, Chengrong Xie
Summary: This brief investigates synchronization of multi-layer networks by a new unified finite-/fixed-time (FTT/FXT) control approach. The study proposes a new unified FTT/FXT stability theorem of dynamical system and gains novel sufficient criteria for FTT/FXT synchronization of multi-layer networks using continuous or discontinuous controllers. A unified framework for FTT/FXT synchronization of multi-layer networks is given, and the relationship between the minimum FTT/FXT and the number of network layers is established, with numerical simulations provided to verify the method's effectiveness.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2021)
Article
Engineering, Electrical & Electronic
Yuhua Xu, Xiaoqun Wu, Bing Mao, Jinhu Lu, Chengrong Xie
Summary: This article focuses on the finite-time intra-/inter-layer quasi-synchronization of a two-layer multi-weighted network. It discusses FT stability and quasi-stability theorems of the dynamical system, and derives novel sufficient criteria for FT intra-/inter-layer quasi-synchronization. The results suggest that the number of multiple weights does not necessarily affect the speed of quasi-synchronization, and may have a positive feedback effect on FT intra-/inter-layer quasi-synchronization.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2021)
Article
Oncology
Xiangqian Guan, Yuyan Lu, Heping Zhu, Shuqi Yu, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Zhenyu Yin
Summary: This study revealed that the release of NETs is increased in HCC patients, especially those with portal vein tumor thrombosis. The presence of NETs in HCC tumor tissues is closely associated with a poor prognosis. Functionally, co-culture of HCC neutrophils enhances the invasion ability of HCC cells through NETs formation, while neutrophils from healthy donors inhibit invasion ability. Mechanistic investigations showed that HCC cells-derived cytokine IL-8 triggers NADPH oxidase-dependent NETs formation, promoting HCC metastasis in vitro and in vivo.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Mathematics, Interdisciplinary Applications
Li Ziyan, Tao Ke, Xia Qing, Xie Chengrong, Xu Yuhua
Summary: This study proposes a financial risk dynamic system and uses a finite-time impulse controller to control the risk, which has a faster convergence speed.
Article
Mathematics, Interdisciplinary Applications
Zheng Gu, Yuhua Xu
Summary: This paper analyzes the chaotic dynamic properties of financial time series through empirical analysis of agriculture index data and wavelet analysis decomposition of daily agriculture index returns. It establishes the dynamic system of some nonlinear characteristic data using Taylor series expansion, and analyzes the corresponding dynamic characteristics. The bifurcation diagram of the system shows complicated bifurcation phenomena, providing insights into the analysis of chaotic phenomena in economic data.
Article
Computer Science, Artificial Intelligence
Na Li, Xiaoqun Wu, Jianwen Feng, Yuhua Xu, Jinhu Lu
Summary: This article introduces a new lemma for fixed-time stability, which is less conservative than existing results. By utilizing simple controllers, a discontinuous neural network with mismatched parameters can synchronize to the target state within a theoretically estimated settling time, independent of initial values. The estimated settling time is closer to the real synchronization time compared to existing literature, as demonstrated through numerical simulations.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2021)
Article
Engineering, Electrical & Electronic
Yuhua Xu, Xiaoqun Wu, Xiaoxiao Wan, Chengrong Xie
Summary: This paper discusses the finite/fixed-time synchronization of multi-layer networks based on energy consumption estimation. A novel FXT stability theorem of dynamical system is presented, and sufficient criteria for FNT/FXT synchronization in multi-layer networks are given. The results show that shorter synchronization time and less energy consumption do not necessarily mean fewer network layers.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2021)
Article
Automation & Control Systems
Wen Sun, Huannan Zheng, Wanli Guo, Yuhua Xu, Jinde Cao, Mahmoud Abdel-Aty, Shihua Chen
Summary: This article presents a study on achieving quasisynchronization in heterogeneous dynamical networks using event-triggered impulsive controls. Two triggered mechanisms, centralized and distributed, are proposed to ensure synchronization error within a specified bound and exclude Zeno behavior. Experimental results show that event-triggered impulsive control has the advantages of low-energy consumption and fewer communication channel occupation compared to time-triggered impulsive control.
IEEE TRANSACTIONS ON CYBERNETICS
(2022)
Article
Automation & Control Systems
Yuhua Xu, Xiaoqun Wu, Bing Mao, Jinhu Lu, Chengrong Xie
Summary: This article studies fixed-time synchronization in complex networks, where fixed-time synchronization is achieved using nonlinear feedback or delay feedback. The optimal combination relationship between the exponential power of fixed-time controllers and the pth moment is given. The effectiveness of the method is verified through numerical simulations.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2022)
Article
Engineering, Electrical & Electronic
Yuhua Xu, Xiaoqun Wu, Xiaoxiao Wan, Huihui Ji, Shichao Zhou
Summary: This paper investigates the problem of finite-time synchronization on stochastic multilayer networks and proposes new quasi-stability theorems and sufficient conditions. Numerical simulations demonstrate the effectiveness of the theoretical analysis.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2022)
Article
Computer Science, Information Systems
Difang Chen, Yuhua Xu, Shijun Luo
Summary: This paper introduces the use of evolutionary game theory and evolutionary graph theory to analyze the evolution of cooperative behavior of nodes in opportunistic networks. A game model is used to study cooperation between nodes and simulations are conducted to verify the model's effectiveness. The reputation model's role in guiding nodes to actively participate in network collaboration during the collaborative evolution process is explored.
Article
Computer Science, Artificial Intelligence
Zhiyong Zhou, Dongbing Tong, Qiaoyu Chen, Wuneng Zhou, Yuhua Xu
Summary: This paper discusses the use of radial basis function-neural networks for approximation in nonlinear systems and dynamic surface control method to address complexity issues, ensuring global asymptotic stability through Lyapunov stability theory. The effectiveness of the proposed control technique is validated through simulation examples.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Guo, Yizhen Pang, Lanlin Yao, Liang Zhao, Chunlei Fan, Jingpeng Ke, Ping Guo, Bing Hao, Hao Fu, Chengrong Xie, Qin Lin, Hua Wu, Long Sun, Haojun Chen
Summary: The study evaluated the potential utility of [Ga-68]Ga-FAPI-04 PET/CT for diagnosing primary and metastatic liver lesions in patients with liver cancer and compared it with other imaging modalities. The findings suggest that [Ga-68]Ga-FAPI-04 PET/CT is comparable to CE-CT and liver MRI in identifying primary liver tumors and metastatic lesions. Additionally, [Ga-68]Ga-FAPI-04 PET/CT outperformed [F-18]-FDG PET/CT in detecting liver lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)