Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu
Summary: The study revealed that fluid shear stress facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, leading to the release of YAP from integrin beta subunit and subsequent activation of EMT-regulating transcription factor SNAI1 and expression of EMT-related genes. FSS-treated HepG2 cells exhibited significantly increased tumorigenesis and metastasis in vivo.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Ying Liu, Dao-Hai Cheng, Ke-Dao Lai, Hua Su, Guo-Shou Lu, Li Wang, Ji-Hua Lv
Summary: Ventilagolin suppresses the migration, invasion, and EMT of HCC cells by downregulating Pim-1, showing potential therapeutic effects. In vivo experiments demonstrate that Ventilagolin effectively inhibits HCC tumor growth and regulates the expression of Pim-1 and EMT-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li, Yan Li
Summary: The study found that BIRC5 was highly expressed in HCC samples and associated with poor prognosis. Through WGCNA, 180 module genes were screened, overlapped with 241 DEGs, ultimately obtaining 33 candidate genes. Cox regression analyses identified 8 genes which were used to construct a risk signature, showing high accuracy in predicting clinical outcomes and closely related to clinicopathological characteristics of HCC patients. IPA suggested these 8 genes were enriched in cancer and immune-related pathways.
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Oncology
Gongmin Zhu, Hongwei Xia, Qiulin Tang, Feng Bi
Summary: The study identified an EMT-related 5-gene signature (PDCD6, TCOF1, TRIM28, EZH2 and FAM83D) for predicting the prognosis of HCC patients. The signature accurately and independently predicted HCC prognosis, and its predictive capacity was validated in external cohorts. Functional experiments revealed that PDCD6 promoted cell migration and invasion in HCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Weihao Kong, Zhongxiang Mao, Chen Han, Zhenxing Ding, Qianqian Yuan, Gaosong Zhang, Chong Li, Xuesheng Wu, Jia Chen, Manyu Guo, Shaocheng Hong, Feng Yu, Rongqiang Liu, Xingyu Wang, Jianlin Zhang
Summary: In this study, a nine-gene signature related to epithelial-mesenchymal transition (EMT) was identified to predict the survival outcome of hepatocellular carcinoma (HCC) patients. The predictive nomogram based on the EMT risk score showed good distinguishing ability and consistency. The EMT risk score was also found to be correlated with immune infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Xianjue Wang, Ping Wei, Ling Yang, Fangyuan Liu, Xin Tong, Xiaoyu Yang, Liya Su
Summary: The study revealed that miR-20a-5p is significantly upregulated in HCC tissues, promoting cell proliferation, migration, and invasion while suppressing apoptosis through regulating the EMT process. Additionally, by downregulating RUNX3, miR-20a-5p activates the EMT pathway, enhancing the malignant behavior of HCC cells.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cell Biology
Xiao Dong, Yang Han, Encheng Zhang, Yuqi Wang, Pingzhao Zhang, Chenji Wang, Lin Zhong, Qi Li
Summary: This study demonstrates that ZEB1 is a substrate of the CRL4-DCAF15 E3 ubiquitin ligase complex, with DCAF15 specifically recognizing the N-terminal zinc finger domain of ZEB1 for degradation through the ubiquitin-proteasome pathway. Knockdown of DCAF15 leads to upregulation of ZEB1 and activation of EMT in HCC, while overexpression of DCAF15 suppresses ZEB1 and inhibits EMT progression, ultimately impacting HCC cell proliferation and invasion. Low DCAF15 expression in HCC patients is associated with poor prognosis, highlighting the importance of the CUL4-DCAF15 E3 ubiquitin ligase complex in regulating ZEB1-mediated malignancy in HCC.
Article
Cell Biology
Yang Zhang, Weixing Ni, Lei Qin
Summary: In this study, the researchers aimed to investigate the role and mechanism of RUFY3 in hepatocellular carcinoma (HCC) progression. Results showed that high expression of RUFY3 was significantly associated with tumor size, microvascular invasion, clinical stage, and poor prognosis in HCC patients. Furthermore, RUFY3 was found to promote HCC cell growth, invasion, and metastasis through activating NF-kappa B-mediated epithelial-mesenchymal transition (EMT). These findings suggest that RUFY3 may serve as a novel target for HCC treatment.
Correction
Oncology
Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie
Summary: The paper has been amended and the revised version can be accessed through the original article.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Seung Kak Shin, Sujin Ryu, Seungyoon Nam, Seung Yeon Ha, Oh Sang Kwon, Yun Soo Kim, Se-Hee Kim, Ju Hyun Kim
Summary: This study evaluated the correlations between clinicopathological characteristics and epithelial-mesenchymal transition (EMT) markers in hepatocellular carcinoma (HCC) patients who underwent surgical resection, and identified a key regulator in the EMT process. The down-expression of E-cadherin and overexpression of p21-activated kinases 1 (PAK1)/Snail in HCC tissues were significantly associated with macrovascular invasion, microvascular invasion, large tumor size, and advanced tumor stage. Patients with these EMT markers showed early recurrence and poor overall survival. In vitro studies showed that inhibition of Rac1 decreased the expression of EMT markers and suppressed the migration and invasion of HCC cells. Therefore, Rac1 may be a potential therapeutic target for inhibiting EMT process in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Article
Biochemistry & Molecular Biology
Jingyu Kuang, Ting Duan, Changsong Gao, Chuanyang Liu, Si Chen, Lv-yun Zhu, Lu Min, Chenyu Lu, Wenlun Wang, Lingyun Zhu
Summary: In this study, the expression of RNF8 was found to be up-regulated in HCC tissues and positively correlated with poor prognosis of HCC. Silencing RNF8 attenuated the migration of HCC cells and inhibited EMT by regulating the expressions of specific proteins. High RNF8 expression predicted poor survival benefits from sorafenib, and RNF8 depletion enhanced the sensitivity of HCC cells to sorafenib and lenvatinib treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Oncology
Yusheng Shi, Xinjing Wang, Weize Wu, Junjie Xie, Jiabin Jin, Chenghong Peng, Xiaxing Deng, Hao Chen, Baiyong Shen
Summary: This study evaluated prognostic factors of patients with resectable pancreatic adenosquamous cancer and found that the survival rate was low, with a 5-year survival rate of only 11.6%. Normal serum levels of Ca199 and Ca125 were identified as independent favorable prognostic factors for predicting prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ningzhen Fu, Weishen Wang, Dongfeng Cheng, Jiancheng Wang, Zhiwei Xu, Xiaxing Deng, Chenghong Peng, Hao Chen, Baiyong Shen
Summary: This study proposed a rescue staging system for pancreatic ductal adenocarcinoma patients with inadequate lymph node examination after pancreatoduodenectomy. The system showed better predictive capacity than the 8th AJCC staging system, as demonstrated by higher C-index values in both SEER and RJPDC databases.
Article
Cell Biology
Zengyu Feng, Kexian Li, Jianyao Lou, Mindi Ma, Yulian Wu, Hao Chen, Chenghong Peng
Summary: The study aims to develop a DNA replication-related gene signature to stratify PDAC patients treated with R0 resection based on recurrence risks. Pathway enrichment analysis suggests a close relationship with cell cycle, DNA replication, and DNA repair, potentially aiding in the identification of novel biomarkers and therapeutic targets for PDAC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Hao Chen, Chenghong Peng, Xiaxing Deng, Chenlei Wen, Baiyong Shen, Qian Zhan
Summary: The new c-MET antibody-drug conjugate SHR-A1403 shows promising potential for targeted treatment of PDAC by significantly inhibiting pancreatic cancer cell proliferation, migration, and invasion, as well as inducing cell cycle arrest and apoptosis through inhibition of intracellular cholesterol biosynthesis. Targeting c-MET through SHR-A1403 demonstrates strong preclinical anti-tumour efficacy in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zengyu Feng, Kexian Li, Jianyao Lou, Yulian Wu, Chenghong Peng
Summary: A novel 8-gene signature based on EMT-related genes was established to predict therapeutic response for PDAC patients, showing good performance in training and validation cohorts and associations with cancer-related pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zengyu Feng, Kexian Li, Yulian Wu, Chenghong Peng
Summary: This study systematically analyzed the potential diagnostic, prognostic, and therapeutic value of DCBLD2 in PDAC, suggesting that DCBLD2 may play an oncogenic role in PDAC with diagnostic, prognostic, and therapeutic potential. These findings need further validation in prospective studies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Jiewei Lin, Zhiwei Xu, Junjie Xie, Xiaxing Deng, Lingxi Jiang, Hao Chen, Chenghong Peng, Hongwei Li, Jiaqiang Zhang, Baiyong Shen
Summary: APOL1 is aberrantly expressed in pancreatic cancer and associated with poor prognosis. Functional experiments showed that APOL1 promotes proliferation and inhibits apoptosis in pancreatic cancer through activating NOTCH1 signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hao Qian, Hongzhe Li, Junjie Xie, Xiongxiong Lu, Fanlu Li, Weishen Wang, Xiaomei Tang, Minmin Shi, Linxi Jiang, Hongwei Li, Hao Chen, Chenghong Peng, Zhiwei Xu, Xiaxing Deng, Baiyong Shen
Summary: The study successfully predicted the prognosis of PDAC patients by constructing an immunity-related 18-gene signature, and found that the high score group showed enrichment in pathways related to cell division and cell cycle, while PD-L1(+) cases in the low score group had worse prognosis but higher T cell infiltration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zengyu Feng, Hao Qian, Kexian Li, Jianyao Lou, Yulian Wu, Chenghong Peng
Summary: This study established a seven-gene signature that can effectively predict the overall survival and disease-free survival of patients with pancreatic ductal adenocarcinoma, providing potential for personalized treatment and management strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zengyu Feng, Peng Chen, Kexian Li, Jianyao Lou, Yulian Wu, Tao Li, Chenghong Peng
Summary: This study developed an effective prognostic signature using ferroptosis-related genes to predict PDAC recurrence. The signature showed stability and independence in both training and validation cohorts, outperforming clinical indicators and previous models. Additionally, the signature was closely associated with multiple cancer-related and drug response pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Editorial Material
Oncology
Weishen Wang, Ziyun Shen, Jun Zhang, Hao Chen, Xiaxing Deng, Chenghong Peng, Junjie Xie, Zhiwei Xu, Baiyong Shen
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weishen Wang, Ziyun Shen, Jun Zhang, Hao Chen, Xiaxing Deng, Chenghong Peng, Junjie Xie, Zhiwei Xu, Baiyong Shen
Summary: The study found that examining a minimum of 19 lymph nodes is crucial for ensuring quality lymph node detection and long-term survival in patients undergoing distal pancreatectomy for pancreatic ductal adenocarcinoma. The ideal cut-off value for lymph node examination was identified using Kaplan-Meier survival analysis and X-tile software.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jiewei Lin, Shuyu Zhai, Siyi Zou, Zhiwei Xu, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Hao Chen, Chenghong Peng, Jiaqiang Zhang, Baiyong Shen
Summary: The study found that FLVCR1-AS1 is downregulated in PC tissues and cell lines, and its overexpression suppresses proliferation, cell cycle, and migration of PC cells. Mechanistically, FLVCR1-AS1 acts as a ceRNA to sequester miR-513c-5p or miR-514b-5p from KLF10 mRNA, relieving their suppressive effects on KLF10 expression. Additionally, FLVCR1-AS1 was shown to be a direct transcriptional target of KLF10, suggesting a novel therapeutic strategy for PC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Jiabin Jin, Shih-min Yin, Yuanchi Weng, Mengmin Chen, Yusheng Shi, Xiayang Ying, Georgios Gemenetzis, Kai Qin, Jun Zhang, Xiaxing Deng, Chenghong Peng, Baiyong Shen
Summary: This study compared the outcomes of venous resection and reconstruction (VR) in robotic-assisted and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adenocarcinoma (PDAC). The results showed similar reconstructed venous patency, postoperative complications, and 90-day mortality between the two groups, but the robotic group had a lower lymph node resection rate.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Shuyu Zhai, Zhiwei Xu, Junjie Xie, Jun Zhang, Xinjing Wang, Chenghong Peng, Hongwei Li, Hao Chen, Baiyong Shen, Xiaxing Deng
Summary: LINC00261 has been identified as a tumor suppressor in pancreatic cancer, inhibiting cancer progression through various mechanisms including inducing cell cycle arrest and apoptosis. Its expression levels are closely associated with pathological stage and prognosis, revealing its crucial role and regulatory mechanisms in pancreatic cancer.
