Role of Trifluoromethyl Substitution in Design of Antimalarial Quinolones: a Comprehensive Review

Synthesis, β- hematin inhibition studies and antimalarial evaluation of new dehydroxy isoquine derivatives against Plasmodium berghei : A promising antimalarial agent

(2018) Edgar A. Valverde et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin and its derivatives in treating protozoan infections beyond malaria

(2017) Cecilia Shi Ni Loo et al.   PHARMACOLOGICAL RESEARCH

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

(2015) Liwang Cui et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei

(2015) Angel H. Romero et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

(2014) Aaron Nilsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

(2014) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

(2013) Tiago Rodrigues et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resistance nailed

(2013) Christopher V. Plowe   NATURE

A plausible mechanism for the antimalarial activity of artemisinin: A computational approach

(2013) Ashutosh Shandilya et al.   Scientific Reports

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Suet C. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Chandrakala Pidathala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

(2012) Yiqun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

(2012) G. A. Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation among Plasmodium falciparum Strains in Their Reliance on Mitochondrial Electron Transport Chain Function

(2011) Hangjun Ke et al.   EUKARYOTIC CELL

Optimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure–Activity and Structure–Property Relationships

(2011) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolones

(2011) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areas

(2011) Brian Greenwood   MALARIA JOURNAL

The development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc1protein complex

(2011) Robin Cowley et al.   MedChemComm

Optimization of endochin-like quinolones for antimalarial activity

(2010) Rolf Winter et al.   EXPERIMENTAL PARASITOLOGY

Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

(2010) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin combination therapy for vivax malaria

(2010) Nicholas M Douglas et al.   LANCET INFECTIOUS DISEASES

Synthesis and antimalarial activity of new atovaquone derivatives

(2009) Salomé El Hage et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound forN-tert-Butyl Isoquine

(2009) Paul M. O’Neill et al.   JOURNAL OF MEDICINAL CHEMISTRY

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Novel amodiaquine congeners as potent antimalarial agents

(2008) Manolo Casagrande et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Structure–Activity Relationships of 4-Pyridones as Potential Antimalarials

(2008) Clive L. Yeates et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antimalarial quinolones: Synthesis, potency, and mechanistic studies

(2007) Rolf W. Winter et al.   EXPERIMENTAL PARASITOLOGY