Article
Engineering, Multidisciplinary
Yi Wang, Zhuowen Hao, Yufeng Zhang, Yingkun Hu, Tianhong Chen, Feifei Yan, Minhao Wu, Chong Zhang, Renxin Chen, Beihai Li, Xinxin Wu, Hanke Li, Qixin Zheng, Xiaodong Guo, Guohui Liu, Zhenwei Zou, Jingfeng Li, Lin Cai
Summary: Bone regeneration requires the interaction of multiple factors, including osteogenesis, osteolysis, angiogenesis, and an appropriate immune microenvironment. Recombinant human parathyroid hormone (PTH1-34) has been proven effective for clinical treatment of osteoporosis. However, its use in local bone repair is limited due to net bone resorption. This study proposes a strategy using multifunctional calcium phosphate (CaP) ceramics to modulate the effects of M1 macrophages and promote bone regeneration. The functionalization of the CaP ceramic scaffold with parathyroid hormone related peptide-1 (PTHrP-1) improves the osteogenic microenvironment, retains osteogenic and angiogenic properties, and achieves slow release of PTHrP-1. The results show that PTHrP-1-TBC is more suitable for bone regeneration than the unmodified peptide or the TBC scaffold alone.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Cell Biology
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan
Summary: This article reviews the effects of PTH, PTHrP, and PTH1R signaling on MSCs in the orofacial region, as well as the potential therapeutic applications for dental and bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Zhiyuan Zou, Le Wang, Zhifei Zhou, Qing Sun, Delong Liu, Yan Chen, Hao Hu, Yu Cai, Sixiong Lin, Zhengran Yu, Bizhi Tan, Wei Guo, Zemin Ling, Xuenong Zou
Summary: The use of hydrogels containing PTH and nHAP can promote cranial bone regeneration by enhancing the expression of osteogenic-related proteins and facilitating osteogenic differentiation of BMSCs through the Notch signaling pathway. Implantation of the hydrogel into a rat cranial defect model showed efficient bone regeneration compared to using the hydrogel alone or nHAP alone, indicating a promising therapeutic effect of combining nHAP and PTH for bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Rene St-Arnaud, Martin Pellicelli, Mahmoud Ismail, Alice Arabian, Toghrul Jafarov, Chengji J. Zhou
Summary: PTH induces phosphorylation of NACA and LRP6, leading to their nuclear translocation and expression of the target gene Lrp6. Knockout of Naca and Lrp6 in mice abolishes the anabolic response to iPTH, indicating that NACA and LRP6 play important roles in ensuring maximal response to iPTH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Eugenia Bertoldo, Giovanni Adami, Maurizio Rossini, Alessandro Giollo, Giovanni Orsolini, Ombretta Viapiana, Davide Gatti, Angelo Fassio
Summary: This review discusses the interaction between endocrine hormones and the immune system in major rheumatic disorders, particularly focusing on the role of bone-related hormones and cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Alejandro Avila-Alvarez, Helena Perez Tato, Andrea Sucasas Alonso, Ana Prado Carro, Jesus Fuentes Carballal
Summary: In preterm newborns, secondary hyperparathyroidism is a frequently occurring but often unrecognized condition. Detecting this condition may be important in guiding nutritional treatment. This study found that cesarean section, oxygen use during resuscitation, invasive mechanical ventilation, and anemia requiring transfusion were independent risk factors for secondary hyperparathyroidism in preterm infants. Additionally, serum calcium, serum phosphate, vitamin D, and the calcium/creatinine ratio in urine were associated with secondary hyperparathyroidism. Furthermore, a predictive model using gestational age and calcium/creatinine ratio in urine demonstrated good accuracy.
Review
Biochemistry & Molecular Biology
Hadla Hariri, Rene St-Arnaud
Summary: This review highlights recent research on the regulatory functions of ubiquitin-specific peptidases (USPs) in osteoblasts and provides insight into the molecular mechanisms governing their actions. It also discusses the role of USP53 in osteoblasts and the complex layers of regulation exerted by USPs on osteoblast signaling. Further studies using knockout mouse models are necessary for a full understanding of the mechanisms underpinning USPs actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sina Muenz, Martina Feger, Michael Foeller
Summary: Renal phosphate and vitamin D metabolism is regulated by fibroblast growth factor 23 (FGF23), primarily produced in bone. FGF23 is influenced by active vitamin D and parathyroid hormone (PTH), and its levels in plasma correlate with disease stage and outcome in renal, inflammatory, and other diseases. This study investigates the role of oncostatin M, a member of the IL-6 family, as a regulator of FGF23 in bone cells.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Ashley R. Sweeney-Ambros, Amy E. Biggs, Nicholas D. Zimmerman, Kenneth A. Mann, Timothy A. Damron, Megan E. Oest
Summary: Post-radiotherapy bone fragility fractures are a common complication in cancer survivors. This study investigated the effects of combined delivery of parathyroid hormone and zoledronic acid on post-radiotherapy bone health and explored the potential use of parathyroid hormone as a bone marrow radioprotectant.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Engineering, Biomedical
Yawu Li, Yao Zha, Weikang Hu, Jia Chen, Shuaibing Liu, Shengmin Zhang, Jianglin Wang
Summary: To systematically repair osteoporotic bone defects, a dynamically movable drug delivery system using monoporous microspheres (MPMs) encapsulating parathyroid hormone (PTH) was developed. The PTH loaded inside MPMs can be gradually released to improve drug concentration and reduce topical accumulation. In vivo evaluation showed that the implant of MPMs-PTH can stimulate regenerative repair of cranial defects and relieve osteoporosis throughout the body.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Bin Sun, Hufei Wang, Bing Xiao, Huichun Yan, Huiqiao Wu, Rongcheng Zhang, Ying Zhang, Wen Yuan, Xing Wang, Changgui Shi
Summary: This study developed a composite hydrogel (PHC) by integrating short-chain chitosan and nanoparticulate hydroxyapatite into a covalent poly (ethylene glycol) network. The PHC hydrogel showed enhanced osteogenesis, high mechanical strength, excellent surface properties, and good biocompatibility. The hydrogel also had immunomodulatory effects, promoting M2 macrophage polarization and suppressing M1 macrophage polarization, while increasing osteogenic capacity and inhibiting osteoclast formation and resorption. Parathyroid hormone (PTH) could be effectively loaded and released in the PHC hydrogel (PTH@PHC), further improving osteogenic ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Han Xia, Yueyang Tian, Yile Lin, Qia Huang, Yuan Xue
Summary: This study found that Insulin-like growth factor-binding protein 7 (IGFBP7) plays an important role in mediating the anabolic effects of parathyroid hormone (PTH). Intermittent PTH administration increased the expression of IGFBP7 in mesenchymal stem cells (MSCs) and pre-osteoblasts. Knockdown of IGFBP7 interrupted the anabolic effects of PTH, while supplementation with IGFBP7 protein enhanced the bone-forming efficacy of PTH. In a mouse model of fracture, administration of IGFBP7 along with PTH accelerated bone healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Banafsheh Safari, Soodabeh Davaran, Ayuob Aghanejad
Summary: Bone tissue engineering aims to create bio-inspired systems with a coordinated combination of cells, scaffolds, and bioactive factors to repair damaged bone tissue. Bioactive factors such as cytokines, growth factors, peptides, and hormonal signals play a significant role in stimulating osteogenic differentiation and proliferation of cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell & Tissue Engineering
Xin-Xin Zhang, Xu Liang, Sen-Rui Li, Kuang-Jin Guo, Dai-Feng Li, Tian-Fang Li
Summary: GC-induced avascular osteonecrosis of femoral head (AOFH) is a devastating complication without available cures. Modified bone marrow mesenchymal stem cell (BMMSCs) implantation can improve treatment efficacy by interfering with the COX-2-PGE-2-HIF-1α pathway and preventing AOFH.
CELL TRANSPLANTATION
(2022)
