Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Article
Biochemistry & Molecular Biology
Hemant Singh, Indu Yadav, Wajid Mohammad Sheikh, Aniruddha Dan, Zenab Darban, Showkat Ahmad Shah, Narayan Chandra Mishra, Syed Shahabuddin, Shabir Hassan, Showkeen Muzamil Bashir, Mukesh Dhanka
Summary: This research focuses on fabricating biological macromolecule-based hydrogel with desirable antibacterial, antioxidant, controlled drug release, cytocompatibility, and wound healing properties. The nanocomposite hydrogel loaded with 500 mu g/ml NC exhibited excellent performance in treating full-thickness wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Haki, Amir Shamloo, Sara-Sadat Eslami, Fatemeh Mir-Mohammad-Sadeghi, Sasan Maleki, Arman Hajizadeh
Summary: The field of tissue engineering aims to overcome the limitations of traditional tissue replacements, and a recent study introduces a chitosan-coated porous skin scaffold based on sodium carboxymethyl cellulose (NaCMC) and sodium alginate (SA) hydrogels. The study found that adding a chitosan coating and allantoin significantly improved the antibacterial properties and cell viability of the scaffolds. Additionally, the composition ratio and cross-linking agent concentration also influenced the performance of the scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Nahideh Asadi, Ahmad Mehdipour, Marjan Ghorbani, Mehran Mesgari-Abbasi, Abolfazl Akbarzadeh, Soodabeh Davaran
Summary: A bilayer wound dressing with multifunctional properties was designed in this study, showing enhanced wound healing performance, including antibacterial, free radical scavenging, and biocompatibility properties. Through a full thickness wound model study, it was found that this scaffold had a faster wound closure rate, effective collagen deposition, quick re-epithelialization, and regulation of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-alpha (TNF-α).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Xiaoxue Wang, Jingliang Wu, Min Wang, Chunbo Lu, Wenfang Li, Qiao Lu, Yanying Li, Bo Lian, Bo Zhang
Summary: Recent research has focused on the development of drug-loaded hydrogels for wound healing. A carboxymethyl chitosan-gelatin hydrogel was chemically cross-linked using genipin as the cross-linking agent to deliver both substance P and DMOG. The synthesized hydrogels showed good biocompatibility and physicochemical properties, with the SP and DMOG combination promoting cell proliferation and facilitating wound healing in vivo. These findings suggest the potential application of this co-loaded drug hydrogel as a wound dressing material.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Peng Chang, Wenchang Zhang, Mi Wu, Rufei Zou, Xiaoqiang Song, Qian Sun, Junqing Gao, Yan Zhao, Yunhui Liu
Summary: The study introduces a new strategy for constructing functional tissue-engineered skin using Minimal Functional Unit of Skin (MFUS) and chitosan/gelatin non-woven fabric as the scaffold. The MFUS-engineered skin could potentially reduce pain and scar formation at different stages.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Nona Nowroozi, Soraya Faraji, Amideddin Nouralishahi, Mohsen Shahrousvand
Summary: The study aimed to fabricate chitosan/graphene oxide/curcumin scaffolds for wound dressing applications, showing excellent antibacterial properties and cell support characteristics. The findings indicate promising potential for wound dressing applications.
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Shuangshuang Zheng, Liying Li, Zeren Jiao, Hong Wang, Yi Nie, Tianqing Liu, Kedong Song
Summary: A novel dECM/Gel/CS scaffold was successfully prepared with appropriate mechanical strength, good antibacterial activity, and high biocompatibility, showing potential for promoting cell growth and new tissue formation in skin tissue engineering. The presence of dECM effectively enhanced cell proliferation, making the scaffold a promising candidate for use in skin tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Amir Shamloo, Zahra Aghababaie, Homa Afjoul, Mehrzad Jami, Mina Razaghzadeh Bidgoli, Manouchehr Vossoughi, Ahmad Ramazani, Kambiz Kamyabhesari
Summary: Physically cross-linked hydrogels were developed by freezing-thawing method with different concentrations of honey for accelerated wound healing. The incorporation of honey increased the flexibility, antibacterial properties, and cell viability of hydrogels, while also accelerating wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Paper & Wood
Yt Jun Cheah, Mohd Heikal Mohd Yunus, Mh Busra Fauzi, Yasuhiko Tabata, Yosuke Hiraoka, Shou Jin Phang, Min Rui Chia, Muhamad Ramdzan Buyong, Muhammad Dain Yazid
Summary: In this study, an acellular gelatin-chitosan-cellulose nanocrystal (GCCNC) scaffold was developed as a potential wound dressing. The GCCNC scaffold showed good physiochemical properties, mechanical properties, and cellular biocompatibility, and was able to maintain normal skin physiological functions. Therefore, it could be used as a potential acellular skin substitute in managing chronic wounds.
Article
Engineering, Environmental
Sawssen Hajji, Naourez Ktari, Riadh Ben Salah, Sami Boufi, Frederic Debeaufort, Moncef Nasri
Summary: An increased interest in preparing wound healing agents based on bio-polymers has led to the development of nanocomposite films reinforced with chitosan-sodium tripolyphosphate nanoparticles. These films demonstrated improved UV-barrier property, tensile strength, and surface wettability with the addition of nanoparticles, although elongation at break was adversely affected. Overall, the incorporation of nanoparticles enhanced the antioxidant and antibacterial efficacies of the films and significantly improved wound healing outcomes in vivo.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Lin Hou, Wei Wang, Mei-Kun Wang, Xue-Song Song
Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)