Article
Engineering, Biomedical
Xiang-Dong Wu, Lin Kang, Jingjing Tian, Yuanhao Wu, Yue Huang, Jieying Liu, Hai Wang, Guixing Qiu, Zhihong Wu
Summary: In this study, a new type of exosomes derived from magnetically actuated bone mesenchymal stem cells (IONP-Exos) was developed, and it was found that IONP-Exos exerted more significant effects on tendon-to-bone healing than normal BMSC-derived exosomes (BMSC-Exos). The study provided new insights into the regulatory roles of IONPs in IONP-Exos communication and their effects on tendon-to-bone integration.
MATERIALS TODAY BIO
(2022)
Article
Cell Biology
Yinxian Yu, Binbin Sun, Zhuoying Wang, Mengkai Yang, Zhi Cui, Subin Lin, Mingming Jin, Chengqing Yi
Summary: The study elucidated the significant role of macrophage-derived exosomes in tendon injury repair, particularly in promoting peritendinous fibrosis via the miR-15b-5p/FGF-1/7/9 pathway. Exosomes containing circRNA-Ep400 can inhibit miR-15b-5p expression and promote FGF1/7/9 expression, leading to increased proliferation and migration of fibroblasts and tenocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Allergy
Xiang Li, Nan Yang, Qi Cheng, Han Zhang, Fen Liu, Yunxiao Shang
Summary: This study demonstrates that miR-21-5p plays a role in regulating macrophage-derived exosomes on EMT of airway epithelial cells through the TGF beta 1/Smad signaling pathway.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Immunology
Min Zhou, Bingshu Li, Cheng Liu, Ming Hu, Jianming Tang, Jie Min, Jianhong Cheng, Li Hong
Summary: The study reveals that M2 macrophages promote myoblast differentiation and muscle regeneration through exosomal miR-501, suggesting a potential therapeutic approach for muscle injuries, including SUI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zechuan Li, Bing Zhang, Jiaming Shang, Yanan Wang, Linglu Jia, Xiao She, Xin Xu, Dongjiao Zhang, Jing Guo, Fan Zhang
Summary: The microRNA-17 was found to be downregulated in diabetic conditions, while its upregulation promoted bone regeneration. Non-diabetic bone marrow stromal cell-derived exosomes facilitate bone regeneration, while diabetic exosomes undermine this effect. These findings provide a promising therapeutic target for treating diabetic bone disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Yuanxue Yang, Yun Zhang, Aiyu Wang, Ailing Duan, Chao Xue, Kaiyun Wang, Ming Zhao, Jianhua Zhang
Summary: This study investigated the resistance of Spodoptera frugiperda to insecticides and the regulatory roles of miRNAs. RNA-Seq analysis revealed that differentially expressed miRNAs play an important role in the insecticide resistance of S. frugiperda. Overexpression of specific miRNAs significantly increased the mortality of S. frugiperda to insecticides.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Jingxian Sun, Zhenying Sun, Ilgiz Gareev, Tao Yan, Xin Chen, Aamir Ahmad, Daming Zhang, Boxian Zhao, Ozal Beylerli, Guang Yang, Shiguang Zhao
Summary: The study revealed a significant decrease in exosomal miR-2276-5p expression in glioma patients compared to non-glioma patients. The expression level of miR-2276-5p was closely associated with the survival rates of patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qinghai Zhu, Yuting Tang, Tian Zhou, Li Yang, Gao Zhang, Ying Meng, Huixin Zhang, Jun Gao, Chenxing Wang, Yu-Xiong Su, Jinhai Ye
Summary: This study found that exosomes derived from pre-differentiated AB-BMSCs carrying specific miRNAs have a positive effect on bone regeneration. The 7-day pre-differentiation of exosomes effectively promoted BMSCs differentiation and activated the PI3K/Akt signaling pathway through differential expression of miRNAs. Gene modification of exosomes provides great potential as a bone regeneration strategy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Xiao-Yu Wang, Xiao-Hui Guan, Zhen-Ping Yu, Jie Wu, Qi-Ming Huang, Ke-Yu Deng, Hong-Bo Xin
Summary: Our study demonstrated that human amniotic stem cells and their conditioned medium significantly reduced hyperpigmentation in both in vivo and in vitro settings, by inhibiting melanin synthesis and promoting melanosome degradation. Additionally, exosomes derived from human amniotic stem cells contained microRNAs that suppressed melanogenesis and promoted melanosome degradation, suggesting potential therapeutic applications for skin hyperpigmentation disorders.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Wangli Ding, Qiuchen Gu, Manman Liu, Junqing Zou, Jianguo Sun, Junrong Zhu
Summary: This study found that exosomes released from astrocytes induced by glucose and oxygen deprivation, as well as those pretreated with berberine, can improve nerve function deficits in ischemic stroke by inhibiting inflammation. This therapy plays a vital role in the treatment of ischemic stroke.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Jinming Tang, Xu Li, Tianli Cheng, Jie Wu
Summary: The study revealed that miR-21-5p promotes cell proliferation, migration, and invasion in lung cancer cells by targeting SMAD7. Additionally, the upregulation of SMAD7 in lung cancer tissues is associated with the inhibition of lung cancer cell proliferation.
Article
Biochemistry & Molecular Biology
Yibo Zhuang, Hongxue Zheng, Yong Yang, Huiping Ni
Summary: The study revealed the association between diabetic kidney disease and the polarization of macrophages, as well as the anti-inflammatory effects of GABA regulating the direction of macrophage polarization. GABA alleviated podocyte injury by reversing the polarization of macrophages and regulating the expression of miR-21a-5p-Tnpo1/miR-25-3p-ATXN3 axis in macrophage-derived exosomes under high glucose conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hanming Wang, Xinyun Song, Chun Song, Xiaoxia Wang, Huiqing Cao
Summary: The study reveals the presence of m(6)A modification in mature miRNAs and its potential impact on cancer-related mRNA responses. Depletion of ALKBH5 alters the m(6)A abundance of miR-21-5p and subsequently affects its target gene expression levels. The m(6)A modification directly affects the silencing potency of miR-21-5p towards target genes in NSCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell & Tissue Engineering
Xiu Cai, Zhi-yu Zhang, Jin-tao Yuan, Dickson Kofi Wiredu Ocansey, Qiang Tu, Xu Zhang, Hui Qian, Wen-rong Xu, Wei Qiu, Fei Mao
Summary: The study demonstrated that hucMSC-derived exosomes inhibited the activation of NLRP3 inflammasomes, reducing cell pyroptosis and protecting against DSS-induced colitis. Furthermore, miR-378a-5p played a vital role in this process.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Long Liu, Fei Xiao, Jie Sun, Qi Wang, Aidong Wang, Fabiao Zhang, Zhu Li, Xuequan Wang, Zheping Fang, Yingli Qiao
Summary: Ischemia reperfusion injury is a major barrier to liver transplantation. This study identified extracellular vesicles as a major cause of hepatic inflammation and tissue damage in liver ischemia reperfusion injury. Hepatocyte-derived exosomal miR-122-5p was found to mediate liver ischemia reperfusion injury by polarizing Kupffer cell, and inhibiting miR-122-5p showed a protective effect against liver ischemia reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yun Qian, Zhixiao Yao, Xu Wang, Yuan Cheng, Zhiwei Fang, Wei-En Yuan, Cunyi Fan, Yuanming Ouyang
CELL PROLIFERATION
(2020)
Article
Orthopedics
Ziyang Sun, Juehong Li, Haomin Cui, Hongjiang Ruan, Wei Wang, Cunyi Fan
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2020)
Article
Chemistry, Multidisciplinary
Jing Wang, Hao Xiong, Tonghe Zhu, Yuan Liu, Haobo Pan, Cunyi Fan, Xiaoli Zhao, William Weijia Lu
Article
Orthopedics
Hao Xiong, Ziyang Sun, Shuai Chen, Wenjun Liu, Shiqiao Peng, Wei Wang, Cunyi Fan
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2020)
Article
Chemistry, Multidisciplinary
Yun Qian, Yuan Cheng, Jialin Song, Yang Xu, Wei-En Yuan, Cunyi Fan, Xianyou Zheng
Article
Immunology
Zhixiao Yao, Juehong Li, Xu Wang, Shiqiao Peng, Jiexin Ning, Yun Qian, Cunyi Fan
JOURNAL OF INFLAMMATION RESEARCH
(2020)
Article
Cell & Tissue Engineering
Juehong Li, Zhixiao Yao, Hao Xiong, Haomin Cui, Xu Wang, Wei Zheng, Yun Qian, Cunyi Fan
STEM CELL RESEARCH & THERAPY
(2020)
Article
Engineering, Biomedical
Fangfang Wang, Xiaolin Liu, Yaling Yu, Rui Zhang, Miaozhong Li, Yuqiang Ding, Shanshan Xi, Junqun Jiang, Chuan Chen, Zhibin Wang, Peng Wei, Jin Mei
Summary: The study revealed that DC kidney scaffolds had a therapeutic effect on chronic renal failure after 5/6 nephrectomy, showing reduced levels of blood urea nitrogen and angiotensin II, decreased expression of inflammatory factors and fibroblast growth factor, lower glomerular sclerosis index, decreased collagen accumulation, and enhanced CD133 expression.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Rui Zhang, Junqun Jiang, Yaling Yu, Fangfang Wang, Niuniu Gao, Yingjie Zhou, Xinlong Wan, Zhibin Wang, Peng Wei, Jin Mei
Summary: Chronic kidney disease is a major global public health problem, with renal fibrosis being a common pathological process in chronic renal failure. Research indicates that renal fibrosis decellularized scaffolds have the potential to serve as a model for cellular mechanisms of tissue fibrosis or donors for tissue engineering. Analysis through histology, proteomics, and ELISA showed changes in the structure and components of fibrotic tissue. The fibrosis model induced by adenine-fed demonstrated changes in the fibrotic scaffold's structure and protein expression, but cytokines associated with renal regeneration post-injury were maintained, indicating potential for tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Yaling Yu, Weiying Zhang, Xuanzhe Liu, Hongshu Wang, Junjie Shen, Huimin Xiao, Jin Mei, Yimin Chai, Gen Wen
Summary: Decellularized biomaterials have shown great potential in regenerative medicine, with good biocompatibility and interaction with the immune system being important factors to consider. Understanding the immunogenicity and immunomodulatory effects of decellularized scaffolds on innate and adaptive immune systems is crucial for their clinical translation. Host responses mediated by decellularized biomaterials can provide insights for further development and application in vivo.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Mathematical & Computational Biology
Shuaiqun Wang, Tianshun Zhang, Wei Kong, Gen Wen, Yaling Yu
Summary: Biomarkers play a crucial role in predicting and diagnosing cancers. This study proposes an improved multi-objective particle swarm optimization algorithm to quantify the relevance of each gene in pathway activity inference, aiming to design effective methods for biomarker extraction. Experimental results on multiple gene datasets demonstrate the effectiveness and performance of the proposed algorithm.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Chuandong Cai, Wei Wang, Jing Liang, Yuange Li, Mingkuan Lu, Wenguo Cui, Cunyi Fan, Lianfu Deng, Yusheng Li, Fei Wang, Shen Liu
Summary: In this study, an innovative composite anti-adhesion patch was designed for on-demand and unidirectional delivery of polyplexes to inhibit fibroblasts proliferation and collagen deposition by silencing the fibrosis gene TGF-beta 1. The patch showed MMP-2-responsive and unidirectional release behaviors, resulting in effective gene silencing effects and inhibition of fibroblasts proliferation. Overall, the composite bilayer patch presents a promising approach for peritendinous anti-adhesion with targeted drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Biomaterials
Jian Zou, Mingkuan Lu, Shuai Chen, Chuandong Cai, Zhixiao Yao, Wenguo Cui, Cunyi Fan, Shen Liu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Materials Science, Biomaterials
Yaling Yu, Haomin Cui, Cheng Zhang, Demin Zhang, Jun Yin, Gen Wen, Yimin Chai
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Pharmacology & Pharmacy
Zhixiao Yao, Tong Xue, Chuandong Cai, Juehong Li, Mingkuan Lu, Xudong Liu, Tuo Jin, Fei Wu, Shen Liu, Cunyi Fan
ADVANCED THERAPEUTICS
(2020)