Article
Veterinary Sciences
Guanhong Lu, Chuanyu He, Xi Yang, Yunyun Cheng, Rui Yang, Jie Song, Siyao Wang, Chunli Wang, Ze Ma, Jiapeng Li, Tianqi Feng, Linlin Hao, Changhong Li
Summary: This study examined the association between ARID4A gene polymorphisms and sperm quality traits in Chinese water buffalo. Multiple single-nucleotide polymorphisms (SNPs) were identified and six of them were found to be associated with at least one sperm quality trait. Additionally, haplotype analysis revealed potential molecular markers for selecting semen with specific traits. The findings highlight the significance of ARID4A gene SNPs in the marker-assisted selection of buffalo breeding.
VETERINARSKI ARHIV
(2022)
Article
Biochemistry & Molecular Biology
Lanxiao Cao, Luyan Gu, Jiali Pu, Dayao Lv, Jun Tian, Xinzhen Yin, Ting Gao, Zhe Song, Jinyu Lu, Gaohua Zhao, Baorong Zhang, Yaping Yan, Guohua Zhao
Summary: This study assessed variant burden in ET-associated genes in a large Chinese population cohort. The findings suggest that the rs10937625 variant in the STK32B gene may increase the risk of ET in the eastern Chinese population.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Marcos Calderon, Manuel J. More, Gustavo A. Gutierrez, Federico Abel Ponce de Leon
Summary: The project aimed to develop an alpaca single nucleotide polymorphism (SNP) microarray to improve the economic benefits and quality of life for small farm producers. The incorporation of molecular marker technology overcame current limitations for genetic improvement programs.
Article
Multidisciplinary Sciences
Yaxin Xu, Wentao Xue, Hongwei Gao, Jiabo Cui, Lingzhi Zhao, Chongge You
Summary: Studies have shown that TLRs gene polymorphisms may play a significant role in HBV and HCV infections, with certain SNPs affecting disease progression and prognosis. However, the exact mechanism of action still requires further exploration.
Article
Biochemistry & Molecular Biology
Saima Suleman, Gagan Chhabra, Rubab Raza, Arslan Hamid, Javed Anver Qureshi, Nihal Ahmad
Summary: This study assessed the association between nsSNPs of the CARD14 gene and psoriasis in a Pakistani population. The study found that two nsSNPs, rs2066965 and rs34367357, were associated with psoriasis, and that the heterozygous genotype of rs2066965 was more prevalent in patients with joint pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Qing Tian, Xiaohui Sun, Chengqian Li, Yong Yang, Binghui Hou, Anmu Xie
Summary: This study evaluates the link between CD33 single nucleotide polymorphisms (SNPs) and vulnerability to Parkinson's disease among the northern Chinese Han population. The findings suggest that CD33 SNPs are associated with Parkinson's disease and may contribute to genetic risk. The study recommends further research with larger sample sizes and diverse populations to explore the relationship between CD33 polymorphisms and Parkinson's disease.
NEUROSCIENCE LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Zixue Xuan, Yiwen Zhang, Jinying Jiang, Xiaowei Zheng, Xiaoping Hu, Xiuli Yang, Yanfei Shao, Guobing Zhang, Ping Huang
Summary: This study identified m(6)A-SNPs associated with breast cancer and explored their potential functions. The SNPs rs4829 and rs9610915 were found to potentially be associated with breast cancer due to having eQTL signals, altered gene expression, and proximity to m(6)A modification sites. Further research is needed to clarify how genetic variation affects epigenetic modification and its functions in breast cancer pathogenesis.
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Genetics & Heredity
Ziqi Jia, Yansong Huang, Jiaqi Liu, Gang Liu, Jiayi Li, Hengyi Xu, Yiwen Jiang, Song Zhang, Yidan Wang, Gang Chen, Guangdong Qiao, Yalun Li
Summary: Through a study on genetic polymorphisms, we found significant associations between breast cancer risk and SNPs rs12493607 (TGFBR2), rs4784227 (CASC16), and rs2046210 (ESR1) in the Chinese female population. Further analysis revealed associations between different subtypes of breast cancer and different SNPs. These findings provide important insights into breast cancer susceptibility and personalized treatment.
Article
Microbiology
Pranab Kumar Mahata, Regina Sharmila Dass, Archana Pan, Babylakshmi Muthusamy
Summary: This study extensively analyzed the morphological features of Aspergillus fungi isolated from fennel seeds, along with their classification, genetic characteristics, and SNP analysis. A total of 14 Aspergillus species were identified from 70 fennel samples, with A. niger and A. flavus being the most common species.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christina Aniol-Nielsen, Christian Enevold, Henrik Toft-Hansen, Claus Henrik Nielsen
Summary: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, and anti-insulin antibodies (IAs) may be associated with insulin treatment in patients with diabetes. This study found that two SNPs in the human insulin gene and two SNPs in the insulin receptor gene were associated with type 1 diabetes and glycaemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Shewaye Fituma Natae, Mohammed Abdulridha Merzah, Janos Sandor, Roza Adany, Zsuzsanna Bereczky, Szilvia Fiatal
Summary: The study aimed to explore the combined VT risk predictability of five strongly associated SNPs and non-genetic risk factors in the Hungarian population. The results revealed that rs6025 and rs2036914 were significantly associated with VT risk, while rs8176719 showed significant association in some models. However, rs2066865 and rs1799963 were not significantly associated. The combination of genetic and non-genetic risk factors significantly increased the accuracy of VT risk prediction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Microbiology
Md-Mafizur Rahman, Sang-Jin Lim, Yung-Chul Park
Summary: A rapid and high-quality method based on single-nucleotide polymorphisms (SNPs) was developed to improve detection and reduce the burden of salmonellosis.
Article
Biochemistry & Molecular Biology
Pei-Liang Wu, Xiao Chun Ling, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Chi-Chun Lai, Shun-Fa Yang, Wei-Chi Wu
Summary: The study found that TIMP-2 gene polymorphisms are associated with the risk and severity of retinopathy of prematurity (ROP). Individuals with rs12600817 gene polymorphism are more likely to develop ROP and have a higher risk. Individuals with rs2889529 gene polymorphism are correlated with the treatment response of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Yuning Song, Yuanyuan Xu, Mingming Liang, Yuxin Zhang, Mao Chen, Jichao Deng, Zhanjun Li
BIOSCIENCE REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Yi Lu, Mingming Liang, Quanjun Zhang, Zhiquan Liu, Yuning Song, Liangxue Lai, Zhanjun Li
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Bing Yao, Mingming Liang, Hongmei Liu, Tingting Sui, Yuning Song, Yuxin Zhang, Jichao Deng, Yuxin Xu, Liangxue Lai, Zhanjun Li
Article
Cell Biology
Mingming Liang, Tingting Sui, Zhiquan Liu, Mao Chen, Hongmei Liu, Huanhuan Shan, Liangxue Lai, Zhanjun Li