Article
Nutrition & Dietetics
Sunil Poudel, Marisol Izquierdo, Maria Leonor Cancela, Paulo J. Gavaia
Summary: Doxorubicin-induced bone loss can be counteracted by antioxidants such as resveratrol and MitoTEMPO. These antioxidants improve mineralization, decrease bone deformities, and reverse the effects of doxorubicin by increasing antioxidant response. Antioxidant supplements effectively prevent bone abnormalities and mineralization defects caused by doxorubicin, showing potential for preventing doxorubicin-induced bone impairment.
Article
Endocrinology & Metabolism
Amanda Stenzel, Abigail Mumme-Monheit, Juliana Sucharov, Macie Walker, Jennyfer M. Mitchell, Bruce Appel, James T. Nichols
Summary: The Notch pathway is critical for craniofacial development, with the her9 gene essential for bone mineralization and working redundantly with her6 in certain craniofacial patterning processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yongwei Du, Gongwen Liu, Zhen Liu, Jianwen Mo, Miao Zheng, Qi Wei, Youjia Xu
Summary: Avermectin, a widely used insecticide, has been found to have significant toxic effects on bone development in zebrafish embryos. It disrupts early bone development, causes abnormal craniofacial chondrogenesis, and reduces bone mineralization. Avermectin also decreases the expression of genes related to osteogenesis and TGF-beta and BMP signaling pathways. The study provides insight into the mechanism of avermectin-induced damage on bone development and demonstrates its toxicity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jerry Maria Sojan, Ratish Raman, Marc Muller, Oliana Carnevali, Jorg Renn
Summary: Zebrafish larvae are increasingly used to study vertebrate skeletal development and human pathologies. Recent research has discovered that probiotics can improve bone health. By using zebrafish transgenic lines, it was found that exposure to two different probiotics can increase osteoblast formation and bone matrix growth and mineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jianan Li, Lang Li, Tingkui Wu, Kun Shi, Zhongwu Bei, Meng Wang, Bingyang Chu, Keqi Xu, Meng Pan, Yicong Li, Xulin Hu, Linghong Zhang, Ying Qu, Zhiyong Qian
Summary: This study develops an injectable thermosensitive hydrogel for repairing bone defects in osteoporosis. The hydrogel modulates the bone damage microenvironment, reduces inflammatory responses, and promotes osteogenesis, offering a promising drug delivery strategy for osteoporotic bone defect repair.
Article
Biology
Ivonne Sehring, Hossein Falah Mohammadi, Melanie Haffner-Luntzer, Anita Ignatius, Markus Huber-Lang, Gilbert Weidinger
Summary: Successful regeneration in amputated zebrafish fins involves coordinated execution of multiple cellular responses. Osteoblast migration is preceded by cell elongation and alignment, regulated by actomyosin dynamics. Osteoblast dedifferentiation and migration can be uncoupled, with NF-kappa B and retinoic acid signaling regulating dedifferentiation, and the complement system and actomyosin dynamics affecting migration. Additionally, osteoblasts dedifferentiate and migrate to both injury sites, but regenerative bone formation only occurs at the distal-facing injury.
Review
Biochemistry & Molecular Biology
Judith Van Wynsberghe, Olivier M. Vanakker
Summary: Zebrafish is an important model organism for studying human diseases, especially bone diseases. The axial skeletons of zebrafish are good indicators for congenital spinal deformities and degenerative disorders. Furthermore, zebrafish models can reflect aberrant mineralization and morphology in the spine caused by certain hereditary multisystemic diseases.
Article
Environmental Sciences
Zhu Zhu, Jing Wang, Qingsheng Cao, Shaozhen Liu, Wenzhi Wei, Hui Yang, Yingying Zhang
Summary: This study demonstrates that long-term parental exposure to BPA severely affects cartilage development and bone mineralization in fish offspring, with the involvement of the MAPK/Wnt/FoxO signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yu Jiang, Zhaomin Zhong, Mingyong Wang, Xian Zhang
Summary: This study aimed to assess the toxicity and effects of 5-HMF in zebrafish. The results showed that high concentrations of 5-HMF caused increased mortality and deformity rates in zebrafish, inhibited cartilage development, reduced bone mineralization, and disrupted the expression of genes related to bone development and reactive oxygen species activity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Aryelle Canedo, Lazaro Wender Oliveira de Jesus, Elisa Flavia Luiz Cardoso Bailao, Thiago Lopes Rocha
Summary: This study summarized the literature on micronucleus (MN) and other nuclear abnormalities (NA) in zebrafish, and their applications in toxicity screening and environmental risk assessment. It was found that MN was the most frequently encountered NA in zebrafish, with 15 other types of nuclear alterations reported. The study also discussed the molecular mechanisms underlying NA in zebrafish, as well as the impact of different pollutants.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Joao M. A. Santos, Vincent Laize, Paulo J. Gavaia, Natercia Conceicao, M. Leonor Cancela
Summary: Ectopic calcification refers to the accumulation of calcium ions in soft tissues due to proteins dysfunction. The traditional model organism for studying abnormal calcium deposition, mice, often have limited understanding of the disease. The zebrafish model has gained popularity recently as it shares similarities with human pathological mineralization disorders and offers insights into potential therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jefferson Pedroso, Sabrina Ester Schneider, Cassia Alves Lima-Rezende, Gean Pablo S. Aguiar, Liz Girardi Muller, J. Vladimir Oliveira, Angelo Piato, Anna Maria Siebel
Summary: This study investigated the effects of resveratrol and piceatannol in controlling seizures in adult zebrafish. The results showed that neither resveratrol nor piceatannol had any anticonvulsant or neuroprotective potential in adult zebrafish.
NEUROCHEMICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Siripat Chaichit, Takuto Sato, Huiqing Yu, Yu-ki Tanaka, Yasumitsu Ogra, Takamasa Mizoguchi, Motoyuki Itoh
Summary: A rapid dexamethasone-induced osteoporosis animal model using zebrafish scales was demonstrated, along with a method to measure the activities of bone-related enzymes. Dexamethasone treatment increased osteoclast activity but did not significantly affect the activities of TRAP and ALP.
Article
Biochemistry & Molecular Biology
Yan Zhu, Shengjun Jiang, Dongdong Xu, Gu Cheng, Bin Shi
Summary: In this study, a core-shell poly(& epsilon;-caprolactone)/chitosan/ polyvinyl alcohol (PCL/CS/PVA) guided bone regeneration (GBR) membrane loaded with resveratrol (RSV) was fabricated. The loaded membrane exhibited superior osteogenic induction ability compared to regular GBR membranes. In vitro and in vivo experiments demonstrated that the PCL/CS/PVA GBR membrane loaded with 0.5% RSV could efficiently release RSV, induce osteogenic differentiation, and promote bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Xue Jiang, Jie Wang, Jin Liu, Haiyan Zhu, Jian Hu, Xingzhen Sun, Wendi Zhou
Summary: This study aimed to investigate if resveratrol (RES) could protect against penconazole (PEN)-induced cardiotoxicity and determine the underlying mechanisms. The results showed that PEN induced adverse cardiac effects through oxidative stress and apoptosis, while RES ameliorated PEN-induced cardiotoxicity by inhibiting oxidative stress and apoptosis. These findings suggest that dietary supplementation of RES could be a novel strategy to mitigate the toxicity of PEN.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Lele Wang, Yingjie Zhao, Shengbo Liu, Yuanhong Li, Shengde Chen, Yubin Lan
Summary: This paper proposes a lightweight model based on the improved YOLOv4 to detect dense plums in orchards. By employing data augmentation and optimizing feature extraction, the improved model achieves better performance in terms of accuracy and speed. Experimental results show that the improved model outperforms other models in plum detection, demonstrating high accuracy and robustness.
FRONTIERS IN PLANT SCIENCE
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Mengyu Huang, Shengbo Liu, Fang Hua
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Dong Chen, Haitang Yue, Shengbo Liu, Lang Meng, Wei Yin
Summary: This study summarized the teaching experience of applying Team-based Learning (TBL) in the clinical pharmacology section of the endodontics clinical course at Wuhan University. The results showed that students had positive attitudes towards the TBL course, as it provided them with teamwork opportunities and accelerated their learning and understanding of therapeutic drugs and materials.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Geochemistry & Geophysics
Yuqin Wang, Kunpeng Ge, Wyn Williams, Hui Zhou, Huapei Wang, Lesleis Nagy, Lisa Tauxe, Jiang Wang, Shengbo Liu, Yang Liu
Summary: Recent research indicates that particles in the transitional zone between the single domain and single vortex regions are susceptible to thermal and external magnetic field instabilities, potentially impacting the accuracy of paleomagnetic interpretations. This study simulates the magnetic behavior of specific-shaped magnetite particles to evaluate their internal magnetization characteristics and influence on paleomagnetic observations. The findings reveal the size and dominant features of the magnetically unstable zone, highlighting their significance in paleomagnetic records.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2022)
Article
Plant Sciences
Wei Zhao, Ting-Hu Ren, Yan-Zheng Zhou, Sheng-Bo Liu, Xin-Yang Huang, Tang-Yuan Ning, Geng Li
Summary: In this study, the K-hib-modified proteins were identified for the first time in soybean leaves using affinity enrichment and high-resolution mass spectrometry-based proteomic techniques. A total of 4251 K-hib sites in 1532 proteins were identified, and these modified proteins are involved in a wide range of cellular processes. The study reveals that K-hib modification is abundant and conserved in soybean and may play an important role in regulating physiological processes in soybean leaves.
Article
Chemistry, Inorganic & Nuclear
Li Li, Shuling Dong, Wendi He, Hongxia Wang, Ping Ding, Shengbo Liu, Wei Qian
Summary: Reaction of a clamplike bipyridine with cupric nitrate results in a discrete metallamacrocycle, while reaction with cuprous nitrate forms a polymer. Both compounds have been characterized through X-ray diffraction and their optical properties, electrochemistry, and thermal stabilities have been measured. The phase purity of the polymer has been confirmed using powder diffraction analysis.
Review
Chemistry, Physical
Jia-Yi Fang, Jin-Long Fan, Sheng-Bo Liu, Sheng-Peng Sun, Yao-Yin Lou
Summary: Ammonia (NH3) is a crucial industrial chemical used for fuel and fertilizer purposes. The conventional Haber-Bosch route for NH3 synthesis is responsible for 1.2% of global annual CO2 emissions. To address this issue, the electrosynthesis of NH3 from nitrate anion (NO3-) reduction has emerged as an alternative method, which not only turns waste into valuable resources but also mitigates the adverse impacts of excessive NO3- contamination in the environment. This review provides an overview of recent advances in electrocatalytic NO3- reduction using Cu-based nanostructured materials, including their performance, modification strategies, and the electrocatalytic mechanism.
Article
Green & Sustainable Science & Technology
Shengbo Liu, Xiaoting Luo, Miaomiao Liu
Summary: The double first-class construction policy is an educational policy in China aimed at building world-class universities and disciplines. This study used the Propensity Score Matching-Difference in Differences (PSM-DID) method to examine the academic impact of the policy. The results showed that the policy promotes the international academic influence of Chinese universities, but this effect is not sustainable.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hailan Liu, Lili Chen, Yan Song, Yanlin He, Ruirui Kang, Shengbo Liu, Chunquan Zhang
Summary: This study analyzed the correlation between left atrial (LA) function parameters measured by AFILA echocardiography and the risk of cerebral ischemic stroke (CIS) in patients with non-valvular paroxysmal atrial fibrillation (NVPAF). The results showed that S_CT could independently predict the risk of CIS in patients with NVPAF.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Engineering, Biomedical
Bin Xu, Fanjun Zeng, Jialong Deng, Lintong Yao, Shengbo Liu, Hengliang Hou, Yucheng Huang, Hongyuan Zhu, Shaowei Wu, Qiaxuan Li, Weijie Zhan, Hongrui Qiu, Huili Wang, Yundong Li, Xianzhu Yang, Ziyang Cao, Yu Zhang, Haiyu Zhou
Summary: This study developed a biomimetic nanoparticle (CMNP@Osi) that combines membrane-mediated homologous and molecular targeting for enhanced drug delivery. This dual-targeting strategy improved the efficacy of osimertinib, a tyrosine kinase inhibitor used in the treatment of non-small cell lung cancer.
BIOACTIVE MATERIALS
(2023)
Meeting Abstract
Oncology
Ting Wang, Liyu Cai, Zefeng Guo, Peimeng You, Shengbo Liu, Hongrui Qiu, Hao Li, Shaowei Wu, Haiyu Zhou
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Peimeng You, Shengbo Liu, Qiaxuan Li, Daipeng Xie, Lintong Yao, Chenguang Guo, Zefeng Guo, Ting Wang, Hongrui Qiu, Yangzhong Guo, Junyu Li, Haiyu Zhou
Summary: A predictive model based on a gene signature related to radiation sensitivity was established to predict whether patients with head and neck squamous cell carcinoma (HNSCC) are suitable for radiotherapy. The model divides patients into radiation-sensitive and radiation-resistant groups, with significantly higher overall survival in the radiation-sensitive group. The study investigates the relationship between variations in radiation sensitivity and the immunological microenvironment, functional pathways, and immunotherapy response, and validates the expression of radiation-related genes in HNSCC through experimental verification.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Information Systems
Shengbo Liu, Liqun Fu
Summary: This paper investigates the potential of improving the end-to-end throughput of a multi-hop wireless network using wireless cut-through transmission based on in-band full-duplex technique. It is found that the achievable throughput is mainly determined by the cut-through mode, spatial reuse factor, protocol overhead, and channel rate. To improve the end-to-end throughput, a low-overhead distributed MAC protocol is designed, along with a transmit-delay mechanism and an algorithm to adaptively select transmission parameters.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hailan Liu, Lili Chen, Yan Song, Yanlin He, Ruirui Kang, Shengbo Liu, Chunquan Zhang
Summary: Measuring LA strain by AFILA is valuable for analyzing LA function in patients with NVPAF and exploring its correlation with CIS risk. LA strain can serve as a better index for the dynamic assessment of LA function, especially for patients with a CHA2DS2-VASc score <2.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Proceedings Paper
Computer Science, Information Systems
Xinglong Han, Shengbo Liu, Liqun Fu
Summary: This paper investigates a full-duplex enabled cellular system operated in the unlicensed mmWave band and formulates a sum rate maximization problem to improve system throughput while suppressing interference. Numerical results show a performance degradation of nearly 29% to ensure fair coexistence with other systems, but a nearly 56% improvement in sum rate compared to half-duplex systems.
2021 IEEE GLOBAL COMMUNICATIONS CONFERENCE (GLOBECOM)
(2021)
