Review
Cell Biology
Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, Maria Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation in inflammatory bowel disease (IBD) can lead to tissue damage and remodeling, ultimately resulting in fibrosis. Epithelial cells play a key role in fibrosis by promoting fibroblast activation and extracellular matrix deposition. Additionally, epithelial cells can undergo epithelial-mesenchymal transition and directly contribute to fibroblast activation and extracellular matrix deposition. Understanding these complex interactions may provide new therapeutic targets for preventing or treating fibrosis in IBD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Bai Ruan, Juan-Li Duan, Hao Xu, Kai-Shan Tao, Hua Han, Guo-Rui Dou, Lin Wang
Summary: Liver sinusoidal endothelial cells undergo partial endothelial mesenchymal transition during liver fibrosis, leading to increased extracellular matrix production without activating cell mobility. Targeting this transitional process may be valuable for antifibrotic treatment of liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Baoyu Chen, Wenhui Dong, Tinghui Shao, Xiulian Miao, Yan Guo, Xingyu Liu, Yifei Feng
Summary: The KDM4-DBC1-SIRT1 pathway was found to regulate EMT and contribute to the development of intestinal fibrosis. Depletion or inhibition of KDM4A attenuated TGF-beta induced EMT and normalized SIRT1 activity. Therefore, targeting this pathway may be a potential strategy for treating intestinal fibrosis in IBDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanwen Mao, Xiaohuan Zhang, Wei Peng, Huiming Liu, Xingchen Zhou, Luqun Liang, Jiayi Xiang, Huifang Zhang, Dan Wang, Lingling Liu, Yuxia Zhou, Fan Zhang, Ying Xiao, Mingjun Shi, Yuanyuan Wang, Bing Guo
Summary: EI24 plays a tumor suppressor role in kidney diseases by inhibiting renal interstitial fibrosis through inhibiting epithelial-mesenchymal transition and excessive extracellular matrix deposition, as well as reducing inflammation by restraining NF-kappa B and JNK pathways.
Article
Immunology
Jia-Xi Duan, Xin-Xin Guan, Hui-Hui Yang, Wen-Xiu Mei, Ping Chen, Jia-Hao Tao, Qing Li, Yong Zhou
Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Katrien De Clercq, Joris Vriens
Summary: EMT is a tightly regulated process essential for normal development but can also lead to fibrosis and cancer progression. Calcium is a key player in translating molecular messages during EMT, and calcium-permeable ion channels play a significant role in influencing cellular phenotype. TRP channels, as cellular sensors, are important proteins involved in decoding physical and chemical stimuli, making them ideal candidates to study in the context of phenotypic transitions like EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue, Tetsuro Watabe
Summary: Oral cancer cells undergoing EMT in response to TGF-beta release EVs that target endothelial cells to induce vascular destabilization, facilitating cancer cell metastasis.
INFLAMMATION AND REGENERATION
(2022)
Article
Chemistry, Medicinal
Syed Afroz Ali, Mohd Aslam Saifi, Chandraiah Godugu, Venu Talla
Summary: The study demonstrated the anti-fibrotic activity of silibinin in pulmonary fibrosis, alleviating inflammatory response and modulating epithelial-mesenchymal phenotypic alterations.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Ying Gao, Li-Juan Lu, Zhao-Zheng Zhang, Xiao Yang, Jun Du, Ke Wen, Hua Huang, Xiao-Peng Wang, Xue-Liang Sun
Summary: In this study, XJS was found to prevent early CD-related intestinal fibrosis by inhibiting EMT and EndoMT through blocking the Notch1 and FGL1 signaling pathways and activating autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruth A. Kelly, Kristin M. Perkumas, Matthew Campbell, G. Jane Farrar, W. Daniel Stamer, Pete Humphries, Jeffrey O'Callaghan, Colm J. O'Brien
Summary: This study found that glaucomatous Schlemm's canal endothelial cells (gSCECs) exhibit a stiffer and more fibrotic phenotype compared to healthy SCECs. gSCECs expressed higher levels of fibrotic markers and increased protein expression of TGF beta-2, a driver of fibrosis. Additionally, gSCECs were larger in size, proliferated and migrated at a higher rate, and showed reduced mitochondrial activity compared to healthy SCECs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nina P. Jordan, Samuel J. Tingle, Victoria G. Shuttleworth, Katie Cooke, Rachael E. Redgrave, Esha Singh, Emily K. Glover, Hafiza B. Ahmad Tajuddin, John A. Kirby, Helen M. Arthur, Chris Ward, Neil S. Sheerin, Simi Ali
Summary: The down-regulation of miR-126-3p is associated with EndMT, with its over-expression preventing the process and maintaining endothelial characteristics while repressing fibronectin expression. Lineage tracing in cardiac and kidney fibrosis models revealed that a significant subpopulation of endothelial-derived cells undergo EndMT and express mesenchymal markers. MiR-126-3p expression is restricted to endothelial cells and down-regulated in fibrotic kidney and heart tissue, making it a potential target for miRNA-based therapeutics in fibrotic organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Weiming Zhao, Lan Wang, Yaxuan Wang, Hongmei Yuan, Mengxia Zhao, Hui Lian, Shuaichen Ma, Kai Xu, Zhongzheng Li, Guoying Yu
Summary: The pathological features of pulmonary fibrosis (PF) involve abnormal activation and proliferation of myofibroblasts as well as excessive deposition of extracellular matrix (ECM). Recent studies have emphasized the crucial role of endothelial cells in the development of PF, with 16% of fibroblasts in fibrotic mice lung tissue being derived from endothelial cells. The endothelial cells undergo endothelial-mesenchymal transition (E(nd)MT), leading to excessive proliferation of endothelial-derived mesenchymal cells, fibroblast accumulation, and ECM deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata
Summary: The study demonstrated that knocking down osteopontin (OPN) using small interfering RNA (siRNA) effectively reduced fibrotic areas in a mouse model of pulmonary fibrosis. OPN siRNA treatment also led to a decrease in inflammatory cell count in bronchoalveolar lavage fluid. Furthermore, both in vitro and in vivo experiments showed that OPN downregulation effectively reduced pulmonary fibrosis and epithelial-mesenchymal transition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Angelique Mottais, Luca Riberi, Andrea Falco, Simone Soccal, Sophie Gohy, Virginia De Rose
Summary: Epithelial-to-mesenchymal transition (EMT) is a reversible process where epithelial cells transform into mesenchymal cells. This transformation is seen in various lung diseases, including lung cancer, interstitial lung diseases, asthma, chronic obstructive pulmonary disease, cystic fibrosis, and bronchiectasis. Chronic inflammation in these diseases can lead to aberrant tissue repair, resulting in structural changes and impaired lung function. Understanding the mechanisms underlying EMT may help identify targets for therapeutic interventions to prevent irreversible structural changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
SeoHyun Cho, Seok-Ho Kim, Dongyun Shin
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Seok-Ho Kim, Shin Hee Hong, Young-Joon Park, Jong-Hyuk Sung, Wonhee Suh, Kyeong Won Lee, Kiwon Jung, Changjin Lim, Jin-Hee Kim, Hyoungsu Kim, Kyong Soo Park, Sang Gyu Park
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Hyun Su Kim, Sungkyun Chung, Moon-Young Song, Changjin Lim, Hyeyoung Shin, Joonseong Hur, Hyuk Kwon, Young-Ger Suh, Eun-Hee Kim, Dongyun Shin, Seok-Ho Kim
Review
Chemistry, Multidisciplinary
Sooyoung Park, Jin-Hee Kim, Seok-Ho Kim, Dongyun Shin
FRONTIERS IN CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Hyo In Kim, Seungbeom Lee, Juhee Lim, Sungkyun Chung, Tae-Sung Koo, Yu-Geun Ji, Young-Ger Suh, Woo Sung Son, Seok-Ho Kim, Hyun Jin Choi
Summary: This study investigates the role of ERRγ in regulating the BDNF signaling pathway and DAergic neuronal phenotype. The ERRγ agonist HPB2 was designed and synthesized, and its effects on BDNF expression and DAergic neuronal phenotype were confirmed in cellular experiments and a mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Taewoo Kim, Hyuk Kwon, Da-Young Lee, Dong-Jun Kim, Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Joonseong Hur, Changjin Lim, Eun-Hee Kim, Dongyun Shin, Seok-Ho Kim
Summary: The total synthesis of corniculatolide compounds has been achieved, showing anti-inflammatory effects especially in inflammatory bowel disease by inhibiting the NF-KB signaling pathway, suggesting therapeutic potential in treating the condition.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
In-Young Chung, Hye-Jeong Jang, Yeon-Ji Yoo, Joonseong Hur, Hyo-Young Oh, Seok-Ho Kim, You-Hee Cho
Summary: This study found that artemisinin has antibacterial activity in Drosophila infections caused by bacterial pathogens, but only kills Vibrio cholerae in vitro. The selective antibacterial activity is attributed to higher intracellular copper levels in V. cholerae.
Article
Biochemistry & Molecular Biology
Taewoo Kim, Haejun Oh, Yoonsu Jeon, Hyeyoung Shin, Juhee Lim, Changjin Lim, Jakyung Yoo, Young-Ger Suh, Seok-Ho Kim, Hyo In Kim, Hyun Su Kim, Woo Sung Son, Hyun Jin Choi
Summary: The discovery and development of small molecules that regulate specific neuronal phenotypes is crucial for treating neurological diseases. In this study, new ERRγ agonists were synthesized and their ability to enhance dopaminergic neuronal phenotypes was validated through experiments.
BIOORGANIC CHEMISTRY
(2022)
Article
Clinical Neurology
Hyo In Kim, Juhee Lim, Hyo-Jung Choi, Seok-Ho Kim, Hyun Jin Choi
Summary: By studying a mouse model of PD associated with LRRK2-G2019S mutation, researchers found that a synthetic ERRγ ligand can enhance adult neurogenesis and improve depression-like behavior. Furthermore, the ERRγ ligand also increased the number of cell spines and dendrites, and upregulated the BDNF/TrkB signaling pathway, suggesting its potential as a novel therapeutic target for PD-related depression.
Article
Biochemistry & Molecular Biology
Taewoo Kim, Hyun Su Kim, Jaebong Jang, Dong-Jun Kim, Jongkook Lee, Dongjoo Lee, Seok-Ho Kim
Summary: This paper presents a concise and scalable method for synthesizing the phytoestrogen 7,2'-dihydroxy-4',5'-dimethoxyisoflavanone. The key steps of the synthesis include the construction of the deoxybenzoin unit and the efficient synthesis of the isoflavanone architecture.
Article
Nutrition & Dietetics
Sun-Mi Yun, Young-Min Han, Moon-Young Song, Da-Young Lee, Hyun Su Kim, Seok-Ho Kim, Eun-Hee Kim
Summary: Fibrosis, especially in patients with inflammatory bowel disease, is a problem that needs to be resolved as it affects almost every organ. TGF-beta signaling plays a key role in intestinal fibrosis and its modulation, such as by using Xanthohumol, could be a potential therapy for fibrosis. This study investigated the anti-fibrotic effect of Xanthohumol on TGF-beta 1-induced intestinal fibrosis in primary human intestinal fibroblasts.
Article
Chemistry, Medicinal
Hyun Su Kim, Hyejin Kong, Taewoo Kim, Changjin Lim, Seungbeom Lee, Seok-Ho Kim, Young-Ger Suh
Summary: This study aimed to elucidate the structural congeners of natural izenamides A, B, and C (1-3) responsible for cathepsin D (CTSD) inhibition. The biologically important core structures of the synthesized izenamide variants were identified. It was confirmed that the natural statine (Sta) unit is a requisite core structure for CTSD inhibition, and statine-incorporated izenamide C variant and 18-epi-izenamide B variant showed more potent CTSD-inhibitory activities than natural izenamides.
Review
Chemistry, Multidisciplinary
Rekha Tamatam, Seok-Ho Kim, Dongyun Shin
Summary: Transition-metal-catalyzed reactions have been widely used in the synthesis of nitrogen-containing heterocyclic compounds called quinazolines. This review summarizes the progress and mechanistic insights of these reactions, as well as discusses their advantages, limitations, and future perspectives.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Taewoo Kim, Sinyoung Cho, Haejun Oh, Joonseong Hur, Haedong Kim, Young-Ho Choi, Seongho Jeon, Young Duk Yang, Seok-Ho Kim
Article
Chemistry, Organic
Sooyoung Park, Seok-Ho Kim, Jin-Hyun Jeong, Dongyun Shin
ORGANIC CHEMISTRY FRONTIERS
(2019)
