Article
Biochemistry & Molecular Biology
Kei Takuma, Shintaro Fujihara, Koji Fujita, Hisakazu Iwama, Mai Nakahara, Kyoko Oura, Tomoko Tadokoro, Shima Mimura, Joji Tani, Tingting Shi, Asahiro Morishita, Hideki Kobara, Takashi Himoto, Tsutomu Masaki
Summary: This study investigates the antitumor mechanism of regorafenib on hepatocellular carcinoma (HCC) and the impact on microRNA (miRNA) expression. The results suggest that regorafenib inhibits cell proliferation and tumor growth in HCC by altering the cell cycle and miRNA expression, particularly downregulating cyclin D1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Elisabeth Findeiss, Sigrid C. Schwarz, Valentin Evsyukov, Thomas W. Roesler, Matthias Hoellerhage, Tasnim Chakroun, Niko-Petteri Nykaenen, Yimin Shen, Wolfgang Wurst, Michael Kohl, Joerg Tost, Guenter U. Hoeglinger
Summary: The study indicates that alpha-synuclein accumulation induces microRNA-mediated aberrant cell cycle activation in post-mitotic dopaminergic neurons, offering potential novel therapeutic targets for Parkinson's disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Martina Tufano, Paolo D'Arrigo, Massimo D'Agostino, Carolina Giordano, Laura Marrone, Elena Cesaro, Maria Fiammetta Romano, Simona Romano
Summary: The study revealed a correlation between PD-L1 expression dynamics in GBM and cyclin-D fluctuation, suggesting FKBP51s might participate in regulating cyclin-D oscillation.
Review
Genetics & Heredity
Mostafa Saleban, Erica L. Harris, James A. Poulter
Summary: D-type cyclins encode G1/S cell cycle checkpoint proteins, which are crucial for determining cell cycle exit and progression. Proper control of cell cycle exit is essential during embryonic development, and defects in the regulation of intracellular D-type cyclins can lead to abnormal initiation of stem cell differentiation in various organ systems. Additionally, abnormal stabilization of D-type cyclins is observed in diseases characterized by excessive cell proliferation, such as cancer and overgrowth disorders. In this review, we will summarize and compare the roles of each D-type cyclin in development and provide examples of how their dysregulation can contribute to disease.
Article
Chemistry, Multidisciplinary
Tong Sun, Yu-jia Xu, Shuo-yi Jiang, Zhuan Xu, Bi-yin Cao, Gautam Sethi, Yuan-ying Zeng, Yan Kong, Xin-liang Mao
Summary: Recent studies have shown that the expression of CCND1 and the dysregulation of USP10 play crucial roles in glioma progression. Interactions between CCND1 and USP10 affect cell cycle control and apoptosis in GBM cells, highlighting their potential as therapeutic targets for GBM patients. The natural product acevaltrate (AVT) derived from Valeriana jatamansi Jones has shown promising effects in inducing GBM cell apoptosis by suppressing USP10-mediated deubiquitination on CCND1.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The present study demonstrated that miR-1297 inhibited proliferation and tumor growth in osteosarcoma by directly targeting CCND2.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Swapna Asuthkar, Sujatha Venkataraman, Janardhan Avilala, Katherine Shishido, Rajeev Vibhakar, Bethany Veo, Ian J. Purvis, Maheedhara R. Guda, Kiran K. Velpula
Summary: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and the standard of care for MB patients includes maximum safe resection, postoperative craniospinal irradiation, and chemotherapy. Recent research has identified SMYD3 as a crucial epigenetic regulator, which activates the transcription of cyclin D3 and drives the growth of Group 3 Myc+ MB cells.
Article
Endocrinology & Metabolism
Xin Li, Xuzhu Gao, Jia Yuan, Fancheng Wang, Xiaolin Xu, Chenglong Wang, Huiqiang Liu, Wencai Guan, Jihong Zhang, Guoxiong Xu
Summary: This study found that CROT is downregulated in ovarian cancer and its expression is negatively correlated with patient prognosis. Overexpression of CROT inhibits OC cell proliferation, migration, invasion, and colony formation, while promoting apoptosis. The miR-33a-5p/CROT axis plays a role in regulating OC cell growth. Additionally, CROT mediates OC cell behaviors through the TGF-beta signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Monu Pandey, Abhirup Mukhopadhyay, Surender K. Sharawat, Sachin Kumar
Summary: SCLC, a smoking-related aggressive cancer, shows universal loss of TP53 and RB1 tumor suppressor genes, with miRNAs playing a key role in regulating cell processes and potential clinical applications in monitoring chemotherapy responses and predicting survival outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Pathology
Sami G. Almalki
Summary: The cell cycle consists of interphase and mitosis, with interphase further divided into G1, S, and G2 phases. The cell grows and prepares for DNA synthesis during G1, undergoes DNA synthesis in S phase, and continues to grow and prepare for mitosis in G2. After mitosis, cytokinesis occurs, resulting in two daughter cells. Dysregulation of the cell cycle is a hallmark of cancer and can contribute to its development and progression. Cyclin inhibitors and checkpoint activators show promise in cancer treatment, especially in combination with other therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Audrey Grossen, Kyle Smith, Nangorgo Coulibaly, Benjamin Arbuckle, Alexander Evans, Stefan Wilhelm, Kenneth Jones, Ian Dunn, Rheal Towner, Dee Wu, Young-Tae Kim, James Battiste
Summary: The invasive capabilities of glioblastoma (GBM) determine its aggressiveness, treatment resistance, and overall mortality. The tumor microenvironment influences the molecular behavior of cells, both epigenetically and genetically. This review outlines the advances made in understanding the physical forces involved in GBM and highlights the need for further research to target these forces and improve patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu
Summary: The study found that hsa_circ_0000520 and CDK2 were highly expressed in cervical cancer tissues, and hsa_circ_0000520 could competitively bind to miR-1296 to affect CDK2 expression, thereby inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sundararajan Venkatesh, Min Li, Toshiro Saito, Mingming Tong, Eman Rashed, Satvik Mareedu, Peiyong Zhai, Clea Barcena, Carlos Lopez-Otin, Ghassan Yehia, Junichi Sadoshima, Carolyn K. Suzuki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Cell Biology
Nandita Niranjan, Satvik Mareedu, Yimin Tian, Kasun Kodippili, Nadezhda Fefelova, Antanina Voit, Lai-Hua Xie, Dongsheng Duan, Gopal J. Babu
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Immunology
Marina Gergues, Vipul Nagula, Sarah A. Bliss, Adam Eljarrah, Seda Ayer, Nikhil Gnanavel, Garima Sinha, Qunfeng Wu, Ghassan Yehia, Steven J. Greco, Jing Qian, Pranela Rameshwar
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Jihoon Nah, Peiyong Zhai, Chun-Yang Huang, Alvaro F. Fernandez, Satvik Mareedu, Beth Levine, Junichi Sadoshima
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Cardiac & Cardiovascular Systems
Satvik Mareedu, Ronald Pachon, Jayapalraj Thilagavathi, Nadezhda Fefelova, Rekha Balakrishnan, Nandita Niranjan, Lai-Hua Xie, Gopal J. Babu
Summary: Reducing SLN expression improves cardiac SERCA function and Ca(2+)i cycling, prevents cardiomyopathy in mdx mice, activates apelin-mediated cardioprotective signaling pathways, and enhances cardiac function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Physiology
Satvik Mareedu, Emily D. Million, Dongsheng Duan, Gopal J. Babu
Summary: Duchenne muscular dystrophy is a muscle-wasting disease caused by the loss of dystrophin, leading to muscle degeneration, necrosis, inflammation, and eventual weakness and premature death. Abnormal elevation of intracellular calcium in the dystrophin-deficient muscle is a major contributing factor to disease progression. Targeting calcium-handling proteins and mechanisms could be a promising therapeutic strategy for DMD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Rekha Balakrishnan, Satvik Mareedu, Gopal J. Babu
Summary: The reduction or elimination of sarcolipin (SLN) expression improves muscle metabolism, reduces oxidative stress, improves muscle pathology, and protects mdx mice from glucose intolerance in the Duchenne muscular dystrophy (DMD) mouse model.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mingming Tong, Risa Mukai, Satvik Mareedu, Peiyong Zhai, Shin-ichi Oka, Chun-Yang Huang, Chiao-Po Hsu, Fawad A. K. Yousufzai, Luke Fritzky, Wataru Mizushima, Gopal J. Babu, Junichi Sadoshima
Summary: DRP1 plays an essential role in mediating two forms of mitophagy during high-fat diet-induced obesity cardiomyopathy.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jamie Francisco, Jin Guan, Yu Zhang, Yasuki Nakada, Satvik Mareedu, Eunah Sung, Che-Ming Hu, Shinichi Oka, Peiyong Zhai, Junichi Sadoshima, Dominic P. Del Re
Summary: Inflammation is a crucial factor in cardiovascular disease, and Yes-associated protein (YAP) has been found to play a key role in modulating inflammation in ischemic injury. This study investigated the role of YAP in non-ischemic cardiac inflammation. The results showed that YAP activation in myeloid cells contributes to cardiac inflammation and fibrosis during pressure overload stress. Inhibition of YAP may be a potential therapeutic target for non-ischemic heart disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Satvik Mareedu, Nadezhda Fefelova, Lai-Hua Xie, Gopal J. Babu
Meeting Abstract
Cardiac & Cardiovascular Systems
Satvik Mareedu, Nadezhda Fefelova, Lai-Hua Xie, Gopal J. Babu
CIRCULATION RESEARCH
(2021)
Review
Oncology
Garima Sinha, Alejandra Ferrer, Caitlyn A. Moore, Yahaira Naaldijk, Pranela Rameshwar
Meeting Abstract
Cardiac & Cardiovascular Systems
Satvik Mareedu, Ronald E. Pachon, Thilagavathi Jayapalraj, Nadezhda Fefelova, Lai-hua Xie, Gopal J. Babu
Meeting Abstract
Cardiac & Cardiovascular Systems
Jihoon Nah, Peiyong Zhai, Alvaro Fernandez, Satvik Mareedu, Beth Levine, Junichi Sadoshima