Article
Immunology
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall, Loreto Rojo Gonzalez, Tobias Wood, Brigida Ranieri, Paula Sureda-Gibert, Oliver Howes, Carmine Pariante, N. I. M. A. NIMA Consortium, Ofer Pasternak, Flavio Dell'Acqua, Federico Turkheimer, Diana Cash
Summary: It has been found that neuroinflammation is crucial in various neurological and psychiatric disorders. Recent studies have shown that diffusion MRI (dMRI) can detect changes in microglial density and morphology related to neuroinflammation, but these studies were mostly conducted ex vivo or in extreme animal models. In this study, the utility of established dMRI methods to detect neuroinflammation in a clinically relevant animal model of sickness behavior was investigated. The results demonstrated that diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) indicated widespread increases in diffusivity in the brains of rats with a lipopolysaccharide challenge. These findings confirm the sensitivity of dMRI to neuroinflammatory processes and contribute to the development of a noninvasive indicator of neuroinflammation for early diagnosis and treatment monitoring in neurological and psychiatric diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Martina Lucignani, Laura Breschi, Maria Camilla Rossi Espagnet, Daniela Longo, Lorenzo Figa Talamanca, Elisa Placidi, Antonio Napolitano
Summary: The NODDI and Bingham-NODDI diffusion MRI models are powerful tools for estimating brain microstructure, but factors such as fitting algorithms, multiband acceleration, shell configuration, age, and hemisphere side can significantly impact model reliability. Higher acceleration factors generally lead to better reliability, while differences in shell configuration and fitting tools also play a role. Overall, the study shows that a 10-minute multi-shell diffusion MRI acquisition for NODDI can yield reliable results in white matter, emphasizing the sensitivity of the Bingham-NODDI model to true subject variability.
Article
Neurosciences
Hamsanandini Radhakrishnan, Sepideh Kiani Shabestari, Mathew Blurton-Jones, Andre Obenaus, Craig E. L. Stark
Summary: Recent advances in diffusion imaging have allowed for the non-invasive detection of explicit neurobiological properties. However, the relationship between these metrics and cytoarchitectural properties is not well-understood. In this study, we use advanced diffusion imaging in the mouse brain to demonstrate the unique relationship between cell counts and diffusion metrics in different brain regions, and propose a framework to predict cell counts from diffusion metrics.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. Furtado, Nathaniel D. Mercaldo, Thomas Vahle, Thomas Benkert, William R. Bradley, Lisa Ratanaprasatporn, Ravi Teja Seethamraju, Mukesh G. Harisinghani, Susanna Lee, Krista Suarez-Weiss, Lale Umutlu, Ciprian Catana, Kelsey L. Pomykala, Liran Domachevsky, Hanna Bernstine, David Groshar, Bruse R. Rosen, Onofrio Antonio Catalano
Summary: This study compared standard (STD-DWI) single-shot echo-planar imaging DWI and simultaneous multislice (SMS) DWI during whole-body positron emission tomography (PET)/MRI in terms of acquisition time, image quality, and lesion detection. The results showed that SMS-DWI shortened the acquisition time and maintained or improved the diagnostic yield in most anatomical regions. Therefore, SMS-DWI has important clinical application prospects in cancer staging and restaging.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R. Shimshek
Summary: TREM2 is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. Mutations in TREM2 have been associated with myelin/neuronal loss and neuroinflammation in neurodegenerative diseases. In the cuprizone model, the involvement of soluble and cleavage-reduced TREM2 in central myelination processes was investigated.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Riccardo De Marco, Itamar Ronen, Francesca Branzoli, Marisa L. Amato, Iris Asllani, Alessandro Colasanti, Neil A. Harrison, Mara Cercignani
Summary: This study demonstrated that DW-MRS may be a powerful tool sensitive to glial cytomorphological changes induced by systemic inflammation. The ADC of the glial metabolite choline was found to significantly increase after LPS administration, with changes in mood ratings.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cong Sun, Xinjuan Zhang, Xin Chen, Tianjia Zhu, Yufan Chen, Jinxia Zhu, Hao Huang, Guangbin Wang
Summary: Single-direction DWI is feasible in assessing fetal corpus callosum, with higher visibility and contrast ratio compared to traditional sequences like HASTE and TrueFISP. It can also improve the diagnostic accuracy for agenesis of the corpus callosum in fetuses.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Lara Fernandez, Louise A. Corben, Hiba Bilal, Martin B. Delatycki, Gary F. Egan, Ian H. Harding
Summary: The extent of neurodegeneration and neuroinflammation in Friedreich ataxia (FRDA) can be quantified using novel neuroimaging approaches. This study found that measures of free-water in the brain can effectively distinguish FRDA patients from controls, with the greatest differences observed in the brainstem and cerebellum.
MOVEMENT DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunfei Zhang, Chun Yang, Liang Liang, Zhang Shi, Shuo Zhu, Caizhong Chen, Yongming Dai, Mengsu Zeng
Summary: This study evaluated the feasibility of 5.0 T high-field DWI in the upper abdomen and assessed the agreement of the ADC values with that from 3.0 T abdominal DWI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas A. Stowe, Ajay P. Singh, Brian R. Barnett, Sue Y. Yi, Paloma C. Frautschi, Albee Messing, Tracy L. Hagemann, John-Paul J. Yu
Summary: This study applied neurite orientation dispersion and density imaging (NODDI) to a rat genetic model of Alexander disease (AxD) to quantitatively investigate neural substrates and brain microstructural changes in AxD and potentially identify novel NODDI biomarkers. The results showed significant effects of genotype on DTI and NODDI brain microstructure measures in the amygdala, hippocampus, neocortex, and thalamus. Additionally, genotype by biological sex interactions were observed in the corpus callosum, hippocampus, and neocortex. This study suggests that biological sex may play a role in the neuropathogenesis of AxD.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunjiao Weng, Yiwen Yang, Ling Yang, Chunhong Hu, Xinxing Ma, Guangzheng Li
Summary: This study evaluated and compared the image quality and feasibility of Z-DWI and C-DWI in breast lesions. The results showed that Z-DWI had superior image quality and the ADC map of Z-DWI was more conducive to the imaging evaluation of breast lesions.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Brian R. Barnett, Sue Y. Yi, McKenzie J. Poetzel, Keith Dodd, Nicholas A. Stowe, John-Paul J. Yu
Summary: NODDI is an emerging MRI DWI technique that allows for non-invasive quantitative assessment of neurite density and morphology, particularly suitable for studying dynamic changes in the developing brain. This advanced method shows enhanced sensitivity and specificity in identifying neurodevelopmental and sex-specific changes in brain microstructure, offering potential applications in psychiatric illness studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunfei Zhang, Ruofan Sheng, Chun Yang, Yongming Dai, Mengsu Zeng
Summary: Compared to 3.0 T rFOV-DWI, 5.0 T rFOV-DWI showed higher signal-to-noise ratio and better image quality at the same anatomical locations. This holds clinical potential for identifying abdominal abnormalities in routine practice.
INSIGHTS INTO IMAGING
(2023)
Article
Neuroimaging
E. Kellner, M. Reisert, A. Rau, J. Hosp, T. Demerath, C. Weiller, H. Urbach
Summary: Diffusion microstructure imaging was applied to acute ischemic stroke, revealing changes in intra-axonal compartment volume fraction and diffusivity. DMI metrics showed improved performance in infarct core delineation compared to conventional ADC-derived segmentation.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Kitae Kim, Beom Joon Kim, Jaewon Huh, Seong Kyu Yang, Mi Hwa Yang, Moon-Ku Han, Cheolkyu Jung, Byung Se Choi, Jae Hyoung Kim, Hee-Joon Bae
Summary: This study established the prevalence of positive conversion in DWI-negative stroke and found that positive conversion is associated with a higher risk of recurrent stroke. Factors associated with positive conversion include early neurologic deterioration, atrial fibrillation, among others.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory D. Avey, Daryn S. Belden, Ryan D. Zea, John-Paul J. Yu
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Psychiatry
Brian R. Barnett, Maribel Torres-Velazquez, Sue Y. Yi, Paul A. Rowley, Emily A. Sawin, C. Dustin Rubinstein, Kathleen Krentz, Jacqueline M. Anderson, Vaishali P. Bakshi, John-Paul J. Yu
TRANSLATIONAL PSYCHIATRY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sue Y. Yi, Brian R. Barnett, John-Paul J. Yu
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Neurosciences
Nicholas M. Vogt, Jack F. Hunt, Nagesh Adluru, Douglas C. Dean, Sterling C. Johnson, Sanjay Asthana, John-Paul J. Yu, Andrew L. Alexander, Barbara B. Bendlin
Article
Biochemistry & Molecular Biology
Brian R. Barnett, Fariba Fathi, Paulo Falco Cobra, Sue Y. Yi, Jacqueline M. Anderson, Hamid R. Eghbalnia, John L. Markley, John-Paul J. Yu
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian R. Barnett, Cameron P. Casey, Maribel Torres-Velazquez, Paul A. Rowley, John-Paul J. Yu
MAGNETIC RESONANCE IMAGING
(2020)
Article
Neurosciences
Brian R. Barnett, Sue Y. Yi, McKenzie J. Poetzel, Keith Dodd, Nicholas A. Stowe, John-Paul J. Yu
Summary: NODDI is an emerging MRI DWI technique that allows for non-invasive quantitative assessment of neurite density and morphology, particularly suitable for studying dynamic changes in the developing brain. This advanced method shows enhanced sensitivity and specificity in identifying neurodevelopmental and sex-specific changes in brain microstructure, offering potential applications in psychiatric illness studies.
Article
Clinical Neurology
A. F. Voter, M. E. Larson, J. W. Garrett, J. -P. J. Yu
Summary: This study evaluated the performance of an artificial intelligence decision support system, Aidoc, for the detection of cervical spinal fractures, revealing poor diagnostic accuracy. Concerns were raised about the generalizability, utility, and rapid deployment of similar algorithms that have not undergone external validation. Further rigorous evaluations are needed before widespread implementation of these tools.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Letter
Anesthesiology
Maribel Torres-Velazquez, Margaret Parker, Amber Bo, Marissa White, Sean Tanabe, Robert A. Pearce, Richard Lennertz, Steve Y. Cho, Barbara Bendlin, Sterling C. Johnson, Vivek Prabhakaran, Alan B. McMillan, Robert D. Sanders
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rodrigo A. Montoro, Ajay P. Singh, John-Paul J. Yu
Summary: Interactions between intestinal microbiota and the central nervous system have a profound impact on brain structure and function. However, our understanding of how gut microbiota affects the brain's microstructure and function through quantitative neuroimaging measures is limited. Further research is needed to bridge this knowledge gap and explore the immense opportunities in this emerging field of study.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sue Y. Yi, Brian R. Barnett, McKenzie J. Poetzel, Nicholas A. Stowe, John-Paul J. Yu
Summary: This study found that NAC treatment can improve early-life, sex-specific neural microstructural deficits, with significant effects observed in male Disc1 sv Delta 2 rats; however, the addition of chronic early-life stress weakens the ability of NAC to restore microstructural deficits.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Orthopedics
Maribel Torres-Velazquez, Christa M. Wille, Samuel A. Hurley, Richard Kijowski, Bryan C. Heiderscheit, Alan B. Mcmillan
Summary: This study demonstrates that radiomics features from MRI can be related to hamstring muscle injury and have the potential to predict the time to return to sport.
SKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas A. Stowe, Ajay P. Singh, Brian R. Barnett, Sue Y. Yi, Paloma C. Frautschi, Albee Messing, Tracy L. Hagemann, John-Paul J. Yu
Summary: This study applied neurite orientation dispersion and density imaging (NODDI) to a rat genetic model of Alexander disease (AxD) to quantitatively investigate neural substrates and brain microstructural changes in AxD and potentially identify novel NODDI biomarkers. The results showed significant effects of genotype on DTI and NODDI brain microstructure measures in the amygdala, hippocampus, neocortex, and thalamus. Additionally, genotype by biological sex interactions were observed in the corpus callosum, hippocampus, and neocortex. This study suggests that biological sex may play a role in the neuropathogenesis of AxD.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maribel Torres-Velazquez, Wei-Jie Chen, Xue Li, Alan B. McMillan
Summary: Deep learning is a subfield of machine learning focused on developing computational models to train artificial intelligence systems by automatically extracting high-level features. In the medical imaging field, deep learning has been successfully applied to address issues where it is difficult to determine relevant image features.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2021)