Article
Optics
Ziyu Hua, Kaiyi Zhu, Yifan Wang, Zhaoli Zeng, Yidong Tan
Summary: A contrast-enhanced ultrasound-modulated laser feedback imaging system is proposed, which exhibits high sensitivity and contrast-to-noise ratio. By using laser feedback technique and clinical microbubbles, the system reduces photon consumption in imaging and enhances contrast. Experimental results show that with higher microbubble concentration and thinner depth, the contrast-to-noise ratio increases.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Environmental Sciences
Una Goncin, Ngoc Ton, Ashwin Reddy, Ahmed El Kaffas, Markus Brinkmann, Steven Machtaler
Summary: This study demonstrates the potential of contrast-enhanced ultrasound (CEUS) imaging for measuring organ blood flow in fish, visualizing contrast enhancement in the liver of rainbow trout, and detecting the effects of drugs on blood flow. CEUS shows promise for exploring different organs, fish species, and the impact of chemical contaminants in future research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Acoustics
Mawia Khairalseed, Kenneth Hoyt
Summary: A generalized mathematical framework called pulse inversion spectral deconvolution (PISD) for contrast-enhanced ultrasound (CEUS) imaging is introduced in this article. The PISD approach is based on Gaussian derivative functions (GDFs) and uses PISD pulses to filter backscattered ultrasound (US) data for isolating nonlinear (NL) microbubble (MB) signals. The study evaluates the role of wide-beam transmit aperture size in CEUS imaging and quantifies image enhancement using a contrast-to-noise ratio (CNR). In vivo data collected in rats demonstrates that PISD-based CEUS imaging improves vascular visualization compared to the NL imaging strategy.
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Pharmacology & Pharmacy
Yingying Liu, Xiaoshu Lai, Yao Zhu, Fengjuan Guo, Lili Su, Gulzira Arkin, Tianzhen He, Jinfeng Xu, Haitao Ran
Summary: In this study, a novel cationic magnetic microbubble (MBM) was developed, which could achieve targeted aggregation under a magnetic field and real-time visualization using ultrasound. These microbubbles had good biocompatibility, enhanced ultrasound contrast, and could accumulate in the target site through magnetic targeting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Yanan Feng, Yongsheng Hao, Yuanyuan Wang, Weijian Song, Shanxin Zhang, Dong Ni, Fei Yan, Litao Sun
Summary: In this study, a nanoscale acoustic probe based on gas vesicles (GVs) was developed by conjugating ZD2 peptides to the biosynthetic GVs. The resulting ZD2-GVs showed excellent binding capability to tumor cells and demonstrated strong penetration ability in tumor tissues. This study suggests that ZD2-GVs can serve as a potential UMI probe for early diagnosis of bladder cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Physical
Agata A. Exner, Michael C. Kolios
Summary: The field of medical ultrasound has seen significant developments with the use of microbubbles as contrast agents. However, the limitations in their clinical applications due to size have led to the exploration of nanobubbles. This review discusses the potential of nanobubbles as imaging agents and therapeutic vehicles, with the aim of shaping the future of medical ultrasound.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yu Wang, Al Christopher De Leon, Reshani Perera, Eric Abenojar, Ramamurthy Gopalakrishnan, James P. Basilion, Xinning Wang, Agata A. Exner
Summary: Ultrasound imaging is commonly used for guiding prostate biopsies, but accurately delineating tumors within the prostate gland remains challenging. This study evaluated a novel nanobubble ultrasound contrast agent targeted to PSMA, showing increased extravasation and retention in PSMA-expressing mouse tumors, potentially improving image-based detection and diagnosis of PCa in the future.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Vertika Pathak, Teresa Nolte, Elena Rama, Anne Rix, Seyed Mohammadali Dadfar, Vera Paefgen, Srinivas Banala, Eva Miriam Buhl, Marek Weiler, Volkmar Schulz, Twan Lammers, Fabian Kiessling
Summary: This study investigated the use of microbubbles containing superparamagnetic iron oxide nanoparticles as molecular MRI contrast agents targeted against angiogenesis in breast cancer. Results indicated that RGD-SPION-MB showed higher retention in angiogenic vessels compared to SPION-MB and RAD-SPION-MB, demonstrating their potential as effective molecular MR/US contrast agents for assessing integrin expression in neovasculature.
Article
Biochemistry & Molecular Biology
Mette L. Johansen, Reshani Perera, Eric Abenojar, Xinning Wang, Jason Vincent, Agata A. Exner, Susann M. Brady-Kalnay
Summary: In this study, molecularly-targeted nanobubbles directed at a cancer biomarker PTPmu showed more rapid and greater tumor enhancement compared to non-targeted nanobubbles, indicating their potential for recognizing tumors using molecular ultrasound imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hengli Yang, Ping Zhao, Yonggang Zhou, Qiaoying Li, Wenbin Cai, Zongxia Zhao, Jian Shen, Kechun Yao, Yunyou Duan
Summary: IR780-NBs-DTX, a novel nanosized ultrasound contrast agents (UCAs), show excellent performance in dual-mode molecular targeted imaging and combined therapy for pancreatic cancer, with high efficiency and potential applications in precise detection and effective therapy of small and metastatic lesions.
SCIENTIFIC REPORTS
(2021)
Article
Acoustics
Sirui Liu, Chenyang Zhao, Rui Zhang, Qian Wang, Ming Wang, Yuxin Jiang, Meng Yang
Summary: This study explored the feasibility of using ultrasound-targeted microbubble destruction (UTMD) to deliver tocilizumab and enhance its effectiveness in treating rheumatoid arthritis (RA). The results showed that the combination of tocilizumab and microbubbles with UTMD significantly reduced inflammation and decreased the expression levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Natacha Jugniot, Rakesh Bam, Emmanuelle J. Meuillet, Evan C. Unger, Ramasamy Paulmurugan
Summary: PDAC is often diagnosed late with limited treatment options, highlighting the urgent need for new imaging technologies with high sensitivity and specificity. CETUS, a novel molecular imaging modality, shows promise for accurate detection of PDAC and has potential clinical translational applications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Marianna E. Horn, Markus Brinkmann, Steven Machtaler
Summary: The intestine is crucial for nutrient uptake and as a defense against pathogens. Inflammation in the intestine can have serious health consequences, and traditional detection methods are invasive. Contrast-enhanced ultrasound (CEUS) imaging presents a non-invasive and cost-effective way to measure inflammation in patients. The use of CEUS has been demonstrated in quantifying vascular perfusion in rainbow trout intestines, showing a potential for broader application in industry and research.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona Turco
Summary: Investigation of a unique second-wave phenomenon in nanobubble contrast-enhanced ultrasound (CEUS) imaging was conducted. The second wave was observed accompanying the first pass of the contrast agent bolus, which has not been previously observed in CEUS with microbubbles. The study aimed to investigate this phenomenon and its potential clinical applications, and found that the characteristics of the second wave differed between tumor and normal tissue, suggesting its potential for cancer diagnosis.
SCIENTIFIC REPORTS
(2022)