Review
Surgery
Qing-Song Xie, Zi-Xiang Chen, Yi-Jun Zhao, Heng Gu, Xiao-Ping Geng, Fu-Bao Liu
Summary: Long-term overall survival after liver resection for non-cirrhotic hepatocellular carcinoma is high, with poor prognosis risk factors including multiple tumors, larger tumor size, non-R0 resection, and invasion of the lymphatic vessels.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Medicine, Research & Experimental
Yinying Chen, Wei Yang, Qilong Chen, Qiong Liu, Jun Liu, Yingying Zhang, Bing Li, Dongfeng Li, Jingyi Nan, Xiaodong Li, Huikun Wu, Xinghua Xiang, Yehui Peng, Jie Wang, Shibing Su, Zhong Wang
Summary: The study utilized a sequential allosteric modules (AMs)-based approach to detect potential predictive risks of hepatocellular carcinoma (HCC) in patients with chronic liver disease. Thirteen oncogenic allosteric modules (OAMs) were identified among chronic hepatitis B (CHB), cirrhosis, and HCC network, leading to the discovery of a three-gene set optimized to distinguish HCC from non-tumor liver tissues with high accuracy. Additionally, the study found that compounds affecting these three genes had a significant inhibitory effect on tumor growth in cell lines.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Maria Tampaki, George V. Papatheodoridis, Evangelos Cholongitas
Summary: Patients with decompensated hepatocellular carcinoma (HCC) have limited therapeutic options and are often excluded from clinical trials. Liver transplantation is the best treatment option, but strict criteria and donor shortages limit its availability. Locoregional treatments may provide a survival benefit if well tolerated. Systemic treatments, particularly immunotherapy, may be the safest choice based on real-life data. Close monitoring is necessary due to the high risk of liver disease deterioration.
Review
Oncology
Giammauro Berardi, Edoardo Maria Muttillo, Marco Colasanti, Germano Mariano, Roberto Luca Meniconi, Stefano Ferretti, Nicola Guglielmo, Marco Angrisani, Alessio Lucarini, Eleonora Garofalo, Davide Chiappori, Ludovica Di Cesare, Damiano Vallati, Paolo Mercantini, Giuseppe Maria Ettorre
Summary: Minimally invasive liver resections are widely performed worldwide, with good short-term and safe long-term outcomes. However, the indications for challenging scenarios such as portal hypertension, advanced cirrhosis, lesions in the posterosuperior segments, and large and recurrent tumors are still debated. Rating: 9/10
Review
Surgery
Virginia J. Aijtink, Vera C. Rutten, Beatrice E. M. Meijer, Renate de Jong, John L. Isaac, Wojciech G. Polak, M. Thamara P. R. Perera, Dimitri Sneiders, Hermien Hartog
Summary: This study assessed the safety of intraoperative blood salvage (IBS) in hepatocellular carcinoma (HCC) patients undergoing liver transplantation. The results showed that the use of IBS during liver transplantation did not impair disease-free survival, increase HCC recurrence, or impair overall survival. Therefore, the use of IBS in liver transplantation for HCC patients is a safe procedure.
Review
Gastroenterology & Hepatology
Jin Hean Koh, Darren Jun Hao Tan, Yuki Ong, Wen Hui Lim, Cheng Han Ng, Phoebe Wen Lin Tay, Jie Ning Yong, Mark D. Muthiah, Eunice X. Tan, Ning Qi Pang, Beom Kyung Kim, Nicholas Syn, Alfred Kow, Brian K. P. Goh, Daniel Q. Huang
Summary: Mortality after LR for HCC is nearly 50% higher compared to LT. Survival between LR and LT were similar in uninodular disease. The risk of recurrence after LR is threefold that of LT.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Darren J. H. Tan, Cheng Han Ng, Maral Amangurbanova, Nancy Sutter, Phoebe Wen Lin Tay, Wen Hui Lim, Jie Ning Yong, Ansel Tang, Nicholas Syn, Mark D. Muthiah, Eunice X. X. Tan, Shravan Dave, Benjamin Tay, Abdul M. Majzoub, Danielle Gerberi, Beom Kyung Kim, Rohit Loomba
Summary: A pooled analysis of time-to-event data revealed that the incidence of hepatocellular carcinoma (HCC) in alcohol-associated cirrhosis is significant, with cumulative risks of 3% and 9% at 5 and 10 years, respectively.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xueliang Zhou, Tengfei Zhang, Yali Sun, Chunwei Li, Xianfei Ding, Yanhui Zhu, Lifeng Li, Zhirui Fan
Summary: This study explores the relationship between the use of aspirin and the incidence of hepatocellular carcinoma (HCC). The results indicate that aspirin use is associated with a lower incidence rate of liver cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Coskun O. Demirtas, Antonio 'Alessio, Lorenza Rimassa, Rohini Sharma, David J. Pinato
Summary: The ALBI grade is an important tool for assessing liver functional reserve in patients with hepatocellular carcinoma, helping to categorize patients into subgroups with different prognoses and optimizing treatment selection and sequencing.
Review
Gastroenterology & Hepatology
Hui Li
Summary: Intercellular crosstalk among various liver cells is crucial in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The interaction between liver sinusoidal endothelial cells (LSECs) and other liver cells plays a vital role in the development and progression of liver fibrosis, and is closely related to the immunosuppressive tumor microenvironment (TME).
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Amit G. Singal, Marco Sanduzzi-Zamparelli, Pierre Nahon, Maxime Ronot, Yujin Hoshida, Nicole Rich, Maria Reig, Valerie Vilgrain, Jorge Marrero, Josep M. Llovet, Neehar D. Parikh, Augusto Villanueva
Summary: Research efforts in liver cancer aim to improve surveillance for hepatocellular carcinoma (HCC) by addressing limitations in risk stratification, underuse of surveillance, and accuracy of screening tests. Proposed strategies include using risk stratification algorithms and biomarkers for identifying at-risk individuals, interventions to increase surveillance, and emerging imaging and blood tests with improved sensitivity and specificity for early HCC detection. Practical and logistical considerations must be taken into account when designing and implementing these validation efforts.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cell Biology
Naoto Fujiwara, Naoto Kubota, Emilie Crouchet, Bhuvaneswari Koneru, Cesia A. Marquez, Arun K. Jajoriya, Gayatri Panda, Tongqi Qian, Shijia Zhu, Nicolas Goossens, Xiaochen Wang, Shuang Liang, Zhenyu Zhong, Sara Lewis, Bachir Taouli, Myron E. Schwartz, Maria Isabel Fiel, Amit G. Singal, Jorge A. Marrero, Austin J. Fobar, Neehar D. Parikh, Indu Raman, Quan-Zhen Li, Masataka Taguri, Atsushi Ono, Hiroshi Aikata, Takashi Nakahara, Hayato Nakagawa, Yuki Matsushita, Ryosuke Tateishi, Kazuhiko Koike, Masahiro Kobayashi, Takaaki Higashi, Shigeki Nakagawa, Yo-ichi Yamashita, Toru Beppu, Hideo Baba, Hiromitsu Kumada, Kazuaki Chayama, Thomas F. Baumert, Yujin Hoshida
Summary: This study analyzed multiple cohorts of NAFLD patients globally to define and validate signatures predictive of long-term HCC risk in NAFLD patients. These signatures can accurately predict the risk of developing HCC in patients and provide assistance for clinical treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Jan-Hendrik Bockmann, Matin Kohsar, John M. Murray, Vanessa Hamed, Maura Dandri, Stefan Luth, Ansgar W. Lohse, Julian Schulze-zur-Wiesch
Summary: The combination of metabolic diseases and CHB significantly increases the rates of liver cirrhosis and liver-related events. Diabetes is the most significant predictor for cirrhosis.
Review
Gastroenterology & Hepatology
Yuichiro Eguchi, Gabriel Wong, I-Heng Lee, Omar Akhtar, Ricardo Lopes, Yoshio Sumida
Summary: In Japan, hepatocellular carcinoma is the most common malignancy and cause of death among NAFLD/NASH patients, with higher mortality observed among those with advanced disease and complications. Early identification and effective treatments are needed.
HEPATOLOGY RESEARCH
(2021)
Review
Oncology
Shenglan Huang, Dan Li, LingLing Zhuang, Liying Sun, Jianbing Wu
Summary: This meta-analysis explored the efficacy and safety of sorafenib in hepatocellular carcinoma patients after radical surgery, revealing that sorafenib can improve overall survival, recurrence-free survival, and reduce recurrence rates without intolerable side effects. More evidence is needed for a definitive conclusion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Masanori Atsukawa, Akihito Tsubota, Hidenori Toyoda, Koichi Takaguchi, Makoto Nakamuta, Tsunamasa Watanabe, Kojiro Michitaka, Tadashi Ikegami, Akito Nozaki, Haruki Uojima, Shinya Fukunishi, Takuya Genda, Hiroshi Abe, Naoki Hotta, Kunihiko Tsuji, Chikara Ogawa, Yoshihiko Tachi, Toshihide Shima, Noritomo Shimada, Chisa Kondo, Takehiro Akahane, Yoshio Aizawa, Yasuhito Tanaka, Takashi Kumada, Katsuhiko Iwakiri
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Makoto Chuma, Hidenori Toyoda, Juntaro Matsuzaki, Yoshimasa Saito, Takashi Kumada, Toshifumi Tada, Yuji Kaneoka, Atsuyuki Maeda, Hideki Yokoo, Koji Ogawa, Toshiya Kamiyama, Akinobu Taketomi, Yoshihiro Matsuno, Keiichi Yazawa, Kazuhisa Takeda, Chikara Kunisaki, Katsuaki Ogushi, Satoshi Moriya, Koji Hara, Akito Nozaki, Masaaki Kondo, Hiroyuki Fukuda, Kazushi Numata, Katsuaki Tanaka, Shin Maeda, Naoya Sakamoto
HEPATOLOGY RESEARCH
(2019)
Article
Immunology
Hidenori Toyoda, Masanori Atsukawa, Haruki Uojima, Akito Nozaki, Hideyuki Tamai, Koichi Takaguchi, Shinichi Fujioka, Makoto Nakamuta, Toshifumi Tada, Satoshi Yasuda, Makoto Chuma, Tomonori Senoh, Akemi Tsutsui, Naoki Yamashita, Atsushi Hiraoka, Kojiro Michitaka, Toshihide Shima, Takehiro Akahane, Ei Itobayashi, Tsunamasa Watanabe, Hiroki Ikeda, Etsuko Iio, Shinya Fukunishi, Toru Asano, Yoshihiko Tachi, Tadashi Ikegami, Kunihiko Tsuji, Hiroshi Abe, Keizo Kato, Shigeru Mikami, Hironao Okubo, Noritomo Shimada, Toru Ishikawa, Yoshihiro Matsumoto, Norio Itokawa, Taeang Arai, Akihito Tsubota, Katsuhiko Iwakiri, Yasuhito Tanaka, Takashi Kumada
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Gastroenterology & Hepatology
Hiroki Ikeda, Tsunamasa Watanabe, Masanori Atsukawa, Hidenori Toyoda, Koichi Takaguchi, Makoto Nakamuta, Nobuyuki Matsumoto, Chiaki Okuse, Toshifumi Tada, Akemi Tsutsui, Naoki Yamashita, Chisa Kondo, Korenobu Hayama, Keizo Kato, Norio Itokawa, Taeang Arai, Noritomo Shimada, Toru Asano, Haruki Uojima, Chikara Ogawa, Shigeru Mikami, Tadashi Ikegami, Shinya Fukunishi, Akira Asai, Etsuko Iio, Akihito Tsubota, Atsushi Hiraoka, Akito Nozaki, Hironao Okubo, Yoshihiko Tachi, Akio Moriya, Tsunekazu Oikawa, Yoshihiro Matsumoto, Shuichi Tsuruoka, Joji Tani, Kan Kikuchi, Katsuhiko Iwakiri, Yasuhito Tanaka, Takashi Kumada
JOURNAL OF VIRAL HEPATITIS
(2019)
Article
Oncology
Makoto Sugimori, Kazuya Sugimori, Hiromi Tsuchiya, Yoshimasa Suzuki, Sho Tsuyuki, Yoshihiro Kaneta, Akane Hirotani, Katsuyuki Sanga, Yuichiro Tozuka, Satoshi Komiyama, Takeshi Sato, Shun Tezuka, Yoshihiro Goda, Kuniyasu Irie, Haruo Miwa, Yuuki Miura, Tomohiro Ishii, Takashi Kaneko, Masatsugu Nagahama, Wataru Shibata, Akito Nozaki, Shin Maeda
Article
Gastroenterology & Hepatology
Hidenori Toyoda, Masanori Atsukawa, Tsunamasa Watanabe, Makoto Nakamuta, Haruki Uojima, Akito Nozaki, Koichi Takaguchi, Shinichi Fujioka, Etsuko Iio, Toshihide Shima, Takehiro Akahane, Shinya Fukunishi, Toru Asano, Kojiro Michitaka, Kunihiko Tsuji, Hiroshi Abe, Shigeru Mikami, Hironao Okubo, Tomomi Okubo, Noritomo Shimada, Toru Ishikawa, Akio Moriya, Joji Tani, Asahiro Morishita, Chikara Ogawa, Yoshihiko Tachi, Hiroki Ikeda, Naoki Yamashita, Satoshi Yasuda, Makoto Chuma, Akemi Tsutsui, Atsushi Hiraoka, Tadashi Ikegami, Takuya Genda, Akihito Tsubota, Tsutomu Masaki, Yasuhito Tanaka, Katsuhiko Iwakiri, Takashi Kumada
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Akito Nozaki, Masanori Atsukawa, Chisa Kondo, Hidenori Toyoda, Makoto Chuma, Makoto Nakamuta, Haruki Uojima, Koichi Takaguchi, Hiroki Ikeda, Tsunamasa Watanabe, Shintaro Ogawa, Norio Itokawa, Taeang Arai, Atsushi Hiraoka, Toru Asano, Shinichi Fujioka, Tadashi Ikegami, Toshihide Shima, Chikara Ogawa, Takehiro Akahane, Noritomo Shimada, Shinya Fukunishi, Hiroshi Abe, Akihito Tsubota, Takuya Genda, Hironao Okubo, Shigeru Mikami, Asahiro Morishita, Akio Moriya, Joji Tani, Yoshihiko Tachi, Naoki Hotta, Toru Ishikawa, Takeshi Okanoue, Yasuhito Tanaka, Takashi Kumada, Katsuhiko Iwakiri, Shin Maeda
HEPATOLOGY INTERNATIONAL
(2020)
Article
Gastroenterology & Hepatology
Tetsuo Takehara, Kazuaki Chayama, Masayuki Kurosaki, Hiroshi Yatsuhashi, Yasuhito Tanaka, Naoki Hiramatsu, Naoya Sakamoto, Yasuhiro Asahina, Akito Nozaki, Toshikazu Nakanom, Yosuke Hagiwara, Hiroko Shimizu, Hiroki Yoshida, Yuhan Huang, Michael Biermer, Leen Vijgen, Norio Hayashi
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Hidenori Toyoda, Masanori Atsukawa, Tsunamasa Watanabe, Makoto Nakamuta, Haruki Uojima, Akito Nozaki, Koichi Takaguchi, Shinichi Fujioka, Etsuko Iio, Toshihide Shima, Takehiro Akahane, Shinya Fukunishi, Toru Asano, Kojiro Michitaka, Kunihiko Tsuji, Hiroshi Abe, Shigeru Mikami, Hironao Okubo, Tomomi Okubo, Noritomo Shimada, Toru Ishikawa, Akio Moriya, Joji Tani, Asahiro Morishita, Chikara Ogawa, Yoshihiko Tachi, Hiroki Ikeda, Naoki Yamashita, Satoshi Yasuda, Makoto Chuma, Akemi Tsutsui, Atsushi Hiraoka, Tadashi Ikegami, Takuya Genda, Akihito Tsubota, Tsutomu Masaki, Katsuhiko Iwakiri, Takashi Kumada, Yasuhito Tanaka, Takeshi Okanoue
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Masanori Atsukawa, Akihito Tsubota, Koichi Takaguchi, Hidenori Toyoda, Motoh Iwasa, Tadashi Ikegami, Makoto Chuma, Akito Nozaki, Haruki Uojima, Atsushi Hiraoka, Shinya Fukunishi, Keisuke Yokohama, Toshifumi Tada, Keizo Kato, Hiroshi Abe, Joji Tani, Hironao Okubo, Tsunamasa Watanabe, Nobuhiro Hattori, Akemi Tsutsui, Tomonori Senoh, Yuji Yoshida, Tomomi Okubo, Norio Itokawa, Ai Nakagawa-Iwashita, Chisa Kondo, Taeang Arai, Kojiro Michitaka, Etsuko Iio, Takashi Kumada, Yasushito Tanaka, Yoshiyuki Takei, Katsuhiko Iwakiri
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Oncology
Makoto Chuma, Haruki Uojima, Kazushi Numata, Hisashi Hidaka, Hidenori Toyoda, Atsushi Hiraoka, Toshifumi Tada, Shunji Hirose, Masanori Atsukawa, Norio Itokawa, Taeang Arai, Makoto Kako, Takahide Nakazawa, Naohisa Wada, Shuitirou Iwasaki, Yuki Miura, Satoshi Hishiki, Shuhei Nishigori, Manabu Morimoto, Nobuhiro Hattori, Katsuaki Ogushi, Akito Nozaki, Hiroyuki Fukuda, Tatehiro Kagawa, Kojiro Michitaka, Takashi Kumada, Shin Maeda
Article
Medicine, General & Internal
Feiqian Wang, Kazushi Numata, Masayuki Nakano, Mikiko Tanabe, Makoto Chuma, Hiromi Nihonmatsu, Akito Nozaki, Katsuaki Ogushi, Wen Luo, Litao Ruan, Masahiro Okada, Masako Otani, Yoshiaki Inayama, Shin Maeda
Article
Infectious Diseases
Masanori Atsukawa, Akihito Tsubota, Chisa Kondo, Hidenori Toyoda, Makoto Nakamuta, Koichi Takaguchi, Tsunamasa Watanabe, Atsushi Hiraoka, Haruki Uojima, Toru Ishikawa, Motoh Iwasa, Toshifumi Tada, Akito Nozaki, Makoto Chuma, Shinya Fukunishi, Akira Asai, Toru Asano, Chikara Ogawa, Hiroshi Abe, Naoki Hotta, Toshihide Shima, Etsuko Iio, Shigeru Mikami, Yoshihiko Tachi, Shinichi Fujioka, Hironao Okubo, Noritomo Shimada, Joji Tani, Isao Hidaka, Akio Moriya, Kunihiko Tsuji, Takehiro Akahane, Naoki Yamashita, Tomomi Okubo, Taeang Arai, Kiyoshi Morita, Kazuhito Kawata, Yasuhito Tanaka, Takeshi Okanoue, Shin Maeda, Takashi Kumada, Katsuhiko Iwakiri
INFECTIOUS DISEASES AND THERAPY
(2020)
Article
Medicine, General & Internal
Feiqian Wang, Kazushi Numata, Hiromi Nihonmatsu, Makoto Chuma, Naomi Ideno, Akito Nozaki, Katsuaki Ogushi, Mikiko Tanab, Masahiro Okada, Wen Luo, Masayuki Nakano, Masako Otani, Yoshiaki Inayama, Shin Maeda
Summary: Imaging methods, particularly contrast-enhanced ultrasound (CEUS), play a crucial role in the non-invasive diagnosis of hepatic lesions, providing real-time images, repeatability, and prompt reporting. In this study, we presented a detailed case of a rare benign tumor and described its features using multimodal imaging techniques. By summarizing recent literature, we provided comprehensive knowledge of conventional imaging methods and CEUS in the diagnosis of hepatic lesions, along with a preliminary discussion of their pathology-based diagnosis mechanism.