Article
Immunology
Min Zhou, Yadi Zhang, Rui Tang, Haiyan Liu, Min Du, Zhi Gao, Zongshu Ji, Haoshu Fang
Summary: The study found significantly increased plasma levels of HMGB1 in ALI patients, and reduced CD4(+)CD25(+)CD127(low) Tregs. Experimental results showed that in HMGB1-induced lung injury, HMGB1 affects the expression of FOXP3 and CTLA-4 through TLR4, reducing the immunosuppressive function of Treg cells.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mesfin Yimam, Teresa Horm, Alexandria O'Neal, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia, Mosi Lin, Alex Gauthier, Jiaqi Wu, Kranti Venkat Mateti, Xiaojian Yang, Katelyn Dial, Sidorela Zefi, Lin L. Mantell
Summary: HMGB1 is upregulated during air pollution-induced oxidative stress and plays a significant role in inflammatory lung injury. A botanical antioxidant composition from Scutellaria baicalensis and Acacia catechu was found to decrease extracellular HMGB1 levels and attenuate acute inflammatory lung injury, suggesting its potential as a protective agent against oxidative-stress-induced lung damage.
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Article
Oncology
Weixin Lai, Xinyu Li, Qian Kong, Han Chen, Yunyao Li, Lu-Hong Xu, Jianpei Fang
Summary: The study revealed that HMGB1/RAGE play a crucial role in drug resistance by regulating autophagy and apoptosis, and promoting the expression of drug efflux proteins like P-gp and MRP after chemotherapy in acute leukemia. Blocking the HMGB1/RAGE axis may be a promising therapeutic target for AL, particularly for patients with refractory or relapsed disease.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Xiaoxia Kong, Liling Lu, Daopeng Lin, Lei Chong, Shunhang Wen, Yaokai Shi, Lidan Lin, Liqin Zhou, Hongyu Zhang, Hailin Zhang
Summary: This study found that FGF10 has a protective effect on acute lung injury. FGF10 can prevent the release of IL-6, TNF-alpha, and IL-1 beta, activate the autophagy pathway, and promote the regeneration of alveolar epithelial cells. The BMP4 signaling pathway plays an important role in the protective effect of FGF10.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Kari Ann Shirey, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: Respiratory viral infections, such as influenza, can lead to severe consequences due to misalignments between circulating strains and predicted vaccine strains. In addition to traditional antiviral treatments, blocking the host's immune response may offer a more effective approach to combat these infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhiling Fu, Xiuying Wu, Fushuang Zheng, Yan Zhang
Summary: Sevoflurane suppresses apoptosis and inflammation by activating protective autophagy, thereby ameliorating LPS-induced ALI. The AMPK/ULK1/PIKFYVE pathway plays a key role in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Junting Xiao, Baijie Tu, Xin Zhou, Xuejun Jiang, Ge Xu, Jun Zhang, Xia Qin, Golamaully Sumayyah, Jingchuan Fan, Bin Wang, Chengzhi Chen, Zhen Zou
Summary: CuONPs are widely used metal nanoparticles in industrial and commercial fields, and are associated with dose-dependent acute lung injury. The loss of lc3b may exacerbate lung injury induced by CuONPs, potentially due to the blockade of mitophagy and accumulation of aberrant mitochondria. Targeting autophagy may be a meaningful strategy against CuONPs-associated respiratory toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Urology & Nephrology
Ruolin Wang, Siheng Shen, Luyong Jian, Shuhua Liu, Qi Yuan, Huahui Guo, Jiasheng Huang, Penghui Chen, Renfa Huang
Summary: This study investigated the role of autophagy in AKI-induced ALI and found that autophagy can effectively ameliorate the injury by suppressing inflammation and oxidative stress.
Article
Immunology
Cheng Wang, Yuting Yang, Chaoqi Zhou, Xianghuang Mei, Jing Liu, Kaihang Luo, Jia Zhou, Cheng Qin, Zhenguo Zeng
Summary: This study investigated the expression of WWOX in mouse lung and epithelial cells and explored its role in the LPS-induced ALI model. The researchers found that overexpressing WWOX could activate autophagy and suppress inflammatory responses, thus protecting against LPS-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Dahuan Li, Chunyan Li, Tianzhong Wang, Chong Zhang, Zhao Zhu, Guoxiu Zhang, Bangjiang Fang
Summary: In sepsis-induced acute lung injury, upregulation of GGPPS1 exacerbates lung damage by inhibiting autophagy and enhancing NLRP3 inflammasome activity, while exogenous GGPP administration reverses this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yunjuan Nie, Junjie Liang, Jie Sun, Jiao Li, Xiaorun Zhai, Peng Zhao
Summary: The study investigated the role and mechanism of neurogenic and exogenous Orexin-A (OXA) in LPS-induced acute lung injury (ALI). The production of OXA in the hypothalamus and lungs was decreased following LPS infection. Administration of exogenous OXA improved lung pathology and reduced inflammatory response by inducing autophagy to suppress macrophage-derived pro-inflammatory cytokine production.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cheng Wang, Xianghuang Mei, Yanrong Wu, Yuting Yang, Zhenguo Zeng
Summary: This study revealed for the first time that cinobufagin inhibited the inflammatory response in LPS-induced ALI, which lays the foundation for further understanding and development of cinobufagin as a potential new drug for ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Huaqin Sun, Hongyi Hu, Xiaoping Xu, Mingsun Fang, Tao Tao, Zhehao Liang
Summary: Dexmedetomidine (DEX) has been shown to attenuate acute lung injury (ALI) induced by cecal ligation perforation (CLP) by downregulating HMGB1 and RAGE. The study further revealed that DEX treatment reduced lung tissue damage, inflammatory cell infiltration, and increased lung permeability in ALI mice. DEX also suppressed MPO activity, inflammatory cytokine levels, and activated the HMGB1/RAGE/NF-kappa B pathway to alleviate ALI.
Article
Immunology
Jiao Ma, Zhuoxiao Han, Rui Jiao, Guanli Yuan, Cuiqing Ma, Xixin Yan, Aihong Meng
Summary: This study aimed to explore the potential mechanism of PM2.5-induced acute lung injury and the role of irisin in this process. The results showed that PM2.5 exposure induced lung injury, which was mitigated by irisin. Additionally, irisin improved the disturbed autophagy flux through AMPK/mTOR signaling pathway. Rating: 9/10.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
