期刊
POLYMERS
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/polym11030459
关键词
cyclodextrin; pyrrole; polypyrrole; polycaprolactone; functionalisation; microfibres; tissue engineering; scaffold
资金
- Czech Science Foundation [16-02316Y]
- Ministry of Education, Youth and Sports of the Czech Republic
- European Union-European Structural and Investment Funds [CZ.02.1.01/0.0/0.0/16_019/0000843]
Polypyrrole is one of the most investigated conductive polymers used for tissue engineering applications because of its advantageous properties and the ability to promote different cell types' adhesion and proliferation. Together with beta-cyclodextrin, which is capable of accommodating helpful biomolecules in its cavity, it would make a perfect couple for use as a scaffold for tissue engineering. Such scaffolds were prepared by the polymerisation of 6-(pyrrol-3-yl)hexanoic acid on polycaprolactone microfibres with subsequent attachment of beta-cyclodextrin on the polypyrrole layer. The materials were deeply characterised by several physical and spectroscopic techniques. Testing of the cyclodextrin enriched composite scaffold revealed its better performance in in vitro experiments compared with pristine polycaprolactone or polypyrrole covered polycaprolactone scaffolds.
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