15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection

Idebenone and coenzyme Q10are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

(2018) Jens Tiefenbach et al.   Disease Models & Mechanisms

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

(2018) Catherine A. Loynes et al.   Science Advances

Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

(2017) Andrew S. Gilbert et al.   Science Advances

Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

(2016) Aleksandra Bojarczuk et al.   Scientific Reports

Cryptococcal Phospholipase B1 Is Required for Intracellular Proliferation and Control of Titan Cell Morphology during Macrophage Infection

(2015) Robert J. Evans et al.   INFECTION AND IMMUNITY

Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4

(2015) Liyun Shen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion

(2015) Jennifer L. Tenor et al.   mBio

The fungal pathogenCryptococcus neoformansmanipulates macrophage phagosome maturation

(2014) Leanne M. Smith et al.   CELLULAR MICROBIOLOGY

Peroxisome Proliferator-Activated Receptor-  Regulates the Expression of Alveolar Macrophage Macrophage Colony-Stimulating Factor

(2014) T. L. Bonfield et al.   JOURNAL OF IMMUNOLOGY

STAT1 Signaling Is Essential for Protection againstCryptococcus neoformansInfection in Mice

(2014) Chrissy M. Leopold Wager et al.   JOURNAL OF IMMUNOLOGY

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

(2014) Kerstin Voelz et al.   Nature Communications

Honokiol: A non-adipogenic PPARγ agonist from nature

(2013) Atanas G. Atanasov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Immunobiology of Prostanoid Receptor Signaling in Connecting Innate and Adaptive Immunity

(2013) Hedi Harizi   Biomed Research International

Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells

(2012) Patricia A. Valdez et al.   IMMUNITY

Identification of PPARgamma Partial Agonists of Natural Origin (I): Development of a Virtual Screening Procedure and In Vitro Validation

(2012) Laura Guasch et al.   PLoS One

Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice

(2012) Yafeng Qiu et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor γ Ligand with Partial and Full Agonist Activityin Vitroandin Vivo

(2011) Kavita Bhalla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype

(2011) Paul C. Norris et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans

(2011) Methee Chayakulkeeree et al.   MOLECULAR MICROBIOLOGY

Automated Analysis of Cryptococcal Macrophage Parasitism Using GFP-Tagged Cryptococci

(2011) Kerstin Voelz et al.   PLoS One

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

A Live Zebrafish-Based Screening System for Human Nuclear Receptor Ligand and Cofactor Discovery

(2010) Jens Tiefenbach et al.   PLoS One

An Integrated Model of Eicosanoid Metabolism and Signaling Based on Lipidomics Flux Analysis

(2009) Shakti Gupta et al.   BIOPHYSICAL JOURNAL

Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

(2009) K. Voelz et al.   INFECTION AND IMMUNITY

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor Cells In vivo

(2008) M. Ahmadi et al.   CANCER RESEARCH

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY

The role of laccase in prostaglandin production byCryptococcus neoformans

(2008) John R. Erb-Downward et al.   MOLECULAR MICROBIOLOGY

Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology

(2008) Hedi Harizi et al.   TRENDS IN MOLECULAR MEDICINE