Article
Biochemistry & Molecular Biology
Tung-Min Yu, Ya-Wen Chuang, Shih-Ting Huang, Jin-An Huang, Cheng-Hsu Chen, Mu-Chi Chung, Chun-Yi Wu, Pi-Yi Chang, Chih-Cheng Hsu, Ming-Ju Wu
Summary: Exposure to contrast media is significantly associated with the risk of dementia, with a particularly high risk of Alzheimer's disease in younger patients without underlying comorbidities.
Article
Clinical Neurology
Tim C. van den Beukel, Frank J. Wolters, Uwe Siebert, Wilko Spiering, M. Arfan Ikram, Meike W. Vernooij, Pim A. de Jong, Daniel Bos
Summary: This study found that intracranial arteriosclerosis is associated with an increased risk of dementia, and this association is partly mediated by an increase in cerebral small vessel disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-Ho Lee
Summary: This study investigates the relationship between severe hypoglycemia and dementia subtypes, as well as their combined effect on overall mortality in patients with type 2 diabetes. The results indicate that severe hypoglycemia is associated with dementia, particularly Alzheimer's disease, and the combination of severe hypoglycemia and dementia leads to higher overall mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Ruixue Song, Kuan-Yu Pan, Hui Xu, Xiuying Qi, Aron S. Buchman, David A. Bennett, Weili Xu
Summary: The study revealed that a higher FGCRS is associated with an increased risk of dementia and AD dementia, with vascular and AD pathologies in the brain likely underlying this association.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biology
Simona Villani, Ottavia Eleonora Ferraro, Tino Emanuele Poloni, Antonio Guaita
Summary: This study aims to evaluate the impact of walking speed, comorbidity, ApoE-e4, and various sociodemographic factors on the onset of dementia. The results of the study suggest that old age, male gender, lower education level, ApoE-e4 carrier status, and slower gait are risk factors for dementia onset, while comorbidity does not affect the onset of dementia.
Article
Medicine, General & Internal
Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi, Chen Mao
Summary: The use of proton pump inhibitors is associated with an increased risk of incident dementia, particularly among APOE epsilon 4 heterozygotes, according to the findings of this large population-based cohort study.
Article
Geriatrics & Gerontology
Gawon Cho, Rebecca A. Betensky, Virginia W. Chang
Summary: This study examined the association between internet usage and dementia among older adults. It found that regular internet usage was associated with a 50% lower risk of dementia compared to non-regular usage.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Dermatology
Tsung-Hsien Chang, Ying-Hsuan Tai, Ying-Xiu Dai, Yun-Ting Chang, Tzeng-Ji Chen, Mu-Hong Chen
Summary: The study found that patients with vitiligo are more likely to develop any type of dementia, especially Alzheimer's disease and vascular dementia. These results remind physicians to pay closer attention to signs of dementia when managing patients with vitiligo.
JOURNAL OF DERMATOLOGY
(2021)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Xiaowen Zhang, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: The study found that hip fracture was associated with an increased risk of dementia among older adults, especially in women. Further research on the potential role of hip fracture in the development of dementia could benefit the management of both conditions in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Parasitology
Hung-Yi Yang, Wu-Chien Chien, Chi-Hsiang Chung, Ruei-Yu Su, Chung-Yu Lai, Chuan-Chi Yang, Nian-Sheng Tzeng
Summary: This study in Taiwan found an association between toxoplasmosis and the risk of dementia, with antibiotic treatment showing a reduced risk of dementia. Further research is needed to explore the underlying mechanisms of these associations.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Wajd Alkabbani, Colleen J. Maxwell, Ruth Ann Marrie, Suzanne L. Tyas, Iliana C. Lega, John-Michael Gamble
Summary: This study examines the association between hypoglycemia and dementia, addressing design challenges using lag period, exposure density sampling (EDS), and inverse probability of treatment weighting (IPTW). After addressing these challenges, the study finds that hypoglycemia contributes to an increased risk of dementia among patients with type 2 diabetes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Jong Bin Bae, Ji Won Han, Junghan Song, Kyunghoon Lee, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: The study showed that both high and low homocysteine levels significantly increased the risk of dementia and AD in older adults. Misuse of vitamin supplements could lead to an increased risk of dementia.
CLINICAL NUTRITION
(2021)
Article
Dermatology
Alexa Magyari, Morgan Ye, David J. Margolis, Charles E. McCulloch, Steven R. Cummings, Kristine Yaffe, Sinead M. Langan, Katrina Abuabara
Summary: The study found that active atopic eczema was associated with a 27% increased risk of incident dementia during follow-up, and the risk increased with the severity of eczema.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Alexa Magyari, Morgan Ye, David J. Margolis, Charles E. McCulloch, Steven R. Cummings, Kristine Yaffe, Katrina Abuabara, Sinead M. Lang
Summary: This study found that active atopic eczema was associated with a small but increased risk of incident dementia, with the association increasing with the severity of atopic eczema.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Geriatrics & Gerontology
Che-Yuan Wu, Carina Iskander, Christa Wang, Lisa Y. Xiong, Baiju R. Shah, Jodi D. Edwards, Moira K. Kapral, Nathan Herrmann, Krista L. Lanctot, Mario Masellis, Richard H. Swartz, Hugo Cogo-Moreira, Bradley J. MacIntosh, Jennifer S. Rabin, Sandra E. Black, Refik Saskin, Walter Swardfager
Summary: This population-based retrospective cohort study in Ontario, Canada found that new use of a sulfonylurea, especially glyburide, was associated with a higher risk of dementia compared with new use of a DPP4 inhibitor in older adults with diabetes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Psychology, Clinical
Jennifer Dykxhoorn, Joseph Hayes, Kavya Ashok, Alma Sorberg Wallin, Christina Dalman
Summary: This study examines the relationship between neighbourhood characteristics and suicidal thoughts and attempts using a longitudinal population-based cohort. The results indicate that compositional factors, such as sociodemographic clustering, explain much of the variation in suicidality, but neighbourhood-level deprivation and average residential trust have independent effects on suicidality.
PSYCHOLOGICAL MEDICINE
(2023)
Biographical-Item
Psychology, Clinical
David Osborn
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Justin C. Yang, Johan H. Thygesen, Nomi Werbeloff, Joseph F. Hayes, David P. J. Osborn
Summary: This study examines the relationship between antipsychotic polypharmacy and adverse drug reactions (ADRs) using electronic health record data. The findings suggest that antipsychotic polypharmacy is associated with an increased risk of hyperprolactinemia and overweight.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pediatrics
Yunha Noh, Han Eol Jeong, Ahhyung Choi, Eun-Young Choi, Bjoern Pasternak, Hedvig Nordeng, Mette Bliddal, Kenneth K. C. Man, Ian C. K. Wong, Dong Keon Yon, Ju-Young Shin
Summary: This cohort study found that prenatal and infant exposure to acid-suppressive medication (ASM) was associated with an increased risk of allergic diseases in children, particularly asthma. However, the association between prenatal exposure and allergic diseases was weak, and clinicians should carefully consider the benefits and risks of prescribing ASMs to children and closely monitor for any safety concerns.
Article
Geriatrics & Gerontology
Hyesung Lee, Yeon-Hee Baek, Ju Hwan Kim, Tzu-Chi Liao, Wallis C. Y. Lau, Kenneth K. C. Man, Xiwen Qin, Stephen Wood, Jenni Ilomaeki, J. Simon Bell, Edward Chia-Cheng Lai, Miriam T. Y. Leung, Adrienne Y. L. Chan, Celine S. L. Chui, Ian C. K. Wong, Ju-Young Shin
Summary: Polypharmacy among older people represents a global challenge, with higher prevalence in Asian countries such as Hong Kong, Taiwan, and South Korea. Australia and the United Kingdom have shown decreasing trends in polypharmacy. Monitoring and optimizing medication treatment for older people in Asia is necessary.
Review
Pharmacology & Pharmacy
Le Gao, Kenneth K. C. Man, Min Fan, Grace M. Q. Ge, Wallis C. Y. Lau, Ching-Lung Cheung, David Coghill, Patrick Ip, Kirstie H. T. W. Wong, Ian C. K. Wong
Summary: Animal studies show that methylphenidate treatment for around 3 months may lead to less mineralized and weaker appendicular bones. A systematic review and a self-controlled case series study were conducted to assess the risk of fractures before and after treatment initiation. The findings suggest that methylphenidate treatment may lower the risk of all-cause fractures, but more research is needed to investigate the effects of treatment duration and sex.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fang Jiang, Chengsheng Ju, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wallis C. Y. Lau, Wai K. Leung
Summary: This study investigated the risk of hospitalization for upper gastrointestinal bleeding (UGIB) in patients who had received H. pylori eradication therapy and were newly started on warfarin or DOACs. The results showed that DOACs had a significantly lower risk of UGIB compared to warfarin in H. pylori-eradicated patients. Additionally, there was no significant difference in UGIB risk between H. pylori-eradicated and H. pylori-negative patients newly started on warfarin or DOACs.
Article
Multidisciplinary Sciences
Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: Extending the interval between doses of mRNA Covid-19 vaccines has been linked with a reduced risk of myocarditis in children and adolescents, but impacts on vaccine effectiveness are not known.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Zhuoran Hu, Hin Moi Youn, Jianchao Quan, Lily Luk Siu Lee, Ivy Lynn Mak, Esther Yee Tak Yu, David Vai-Kiong Chao, Welchie Wai Kit Ko, Ian Chi Kei Wong, Gary Kui Kai Lau, Chak Sing Lau, Cindy Lo Kuen Lam, Eric Yuk Fai Wan
Summary: This systematic review investigates the indirect impact of the COVID-19 pandemic on the metabolic management of individuals with type 2 diabetes without a history of COVID-19 infection. The review found no significant changes in HbA1c and BMI among people with type 2 diabetes, but there may be a worsening of lipid parameters during the pandemic.
PRIMARY CARE DIABETES
(2023)
Article
Psychology, Biological
Clara Calvert, Meredith (Merilee) Brockway, Helga Zoega, Jessica E. Miller, Jasper V. Been, Adeladza Kofi Amegah, Amy Racine-Poon, Solmaz Eradat Oskoui, Ishaya I. Abok, Nima Aghaeepour, Christie D. Akwaowo, Belal N. Alshaikh, Adejumoke I. Ayede, Fabiana Bacchini, Behzad Barekatain, Rodrigo Barnes, Karolina Bebak, Anick Berard, Zulfiqar A. Bhutta, Jeffrey R. Brook, Lenroy R. Bryan, Kim N. Cajachagua-Torres, Marsha Campbell-Yeo, Dinh-Toi Chu, Kristin L. Connor, Luc Cornette, Sandra Cortes, Mandy Daly, Christian Debauche, Iyabode Olabisi F. Dedeke, Kristjana Einarsdottir, Hilde Engjom, Guadalupe Estrada-Gutierrez, Ilaria Fantasia, Nicole M. Fiorentino, Meredith Franklin, Abigail Fraser, Onesmus W. Gachuno, Linda A. Gallo, Mika Gissler, Siri E. Haberg, Abbas Habibelahi, Jonas Haeggstroem, Lauren Hookham, Lisa Hui, Luis Huicho, Karen J. Hunter, Sayeeda Huq, K. C. Ashish, Seilesh Kadambari, Roya Kelishadi, Narjes Khalili, Joanna Kippen, Kirsty Le Doare, Javier Llorca, Laura A. Magee, Maria C. Magnus, Kenneth K. C. Man, Patrick M. Mburugu, Rishi P. Mediratta, Andrew D. Morris, Nazeem Muhajarine, Rachel H. Mulholland, Livia Nagy Bonnard, Victoria Nakibuuka, Natasha Nassar, Sylvester D. Nyadanu, Laura Oakley, Adesina Oladokun, Oladapo O. Olayemi, Olanike A. Olutekunbi, Rosena O. Oluwafemi, Taofik O. Ogunkunle, Chris Orton, Anne K. oertqvist, Joseph Ouma, Oyejoke Oyapero, Kirsten R. Palmer, Lars H. Pedersen, Gavin Pereira, Isabel Pereyra, Roy K. Philip, Dominik Pruski, Marcin Przybylski, Hugo G. Quezada-Pinedo, Annette K. Regan, Natasha R. Rhoda, Tonia A. Rihs, Taylor Riley, Thiago Augusto Hernandes Rocha, Daniel L. Rolnik, Christoph Saner, Francisco J. Schneuer, Vivienne L. Souter, Olof Stephansson, Shengzhi Sun, Emma M. Swift, Miklos Szabo, Marleen Temmerman, Lloyd Tooke, Marcelo L. Urquia, Peter von Dadelszen, Gregory A. Wellenius, Clare Whitehead, Ian C. K. Wong, Rachael Wood, Katarzyna Wroblewska-Seniuk, Kojo Yeboah-Antwi, Christopher S. Yilgwan, Agnieszka Zawiejska, Aziz Sheikh, Natalie Rodriguez, David Burgner, Sarah J. Stock, Meghan B. Azad
Summary: An analysis of 52 million births in 26 countries suggests that there were slight reductions in preterm birth rates during the first to third months of lockdown. However, further research is needed to understand the causal pathways. Preterm birth is a significant cause of infant mortality globally. The study also found variations in stillbirth rates across different countries. The findings highlight the importance of studying the effects of lockdown measures on birth outcomes.
NATURE HUMAN BEHAVIOUR
(2023)
Letter
Medicine, General & Internal
Ubonphan Chaichana, Kenneth K. C. Man, Anthony Chen, Ian C. K. Wong, Jacob George, Peter Wilson, Li Wei
Summary: This cross-sectional study investigates the variations in definitions of post-COVID-19 conditions found in published studies.
Article
Medicine, General & Internal
Gloria Hoi-Yee Li, Ching -Lung Cheung, Kathryn Choon-Beng Tan, Annie Wai-Chee Kung, Timothy Chi-Yui Kwok, Wallis Cheuk-Yin Lau, Janus Siu-Him Wong, Warrington W. Q. Hsu, Christian Fang, Ian Chi-Kei Wong
Summary: Sex-specific hip fracture prediction models were developed using electronic health records (EHR) without bone mineral density (BMD) data. The logistic regression (LR) model showed better discrimination and classification performance than machine learning (ML) algorithms in both internal and independent validation cohorts for both females and males. The LR models could be integrated into routine clinical workflow to identify high-risk individuals for DXA scan.
Article
Psychiatry
Vanessa W. S. Ng, Miriam T. Y. Leung, Esther W. Chan, Edwin H. M. Lee, Joseph F. Hayes, David P. J. Osborn, Yun Kwok Wing, Wallis C. Y. Lau, Kenneth K. C. Man, Ian C. K. Wong
Summary: This study used a self-controlled case series design to examine the association between mood stabilizing agents and suicide attempts in patients with bipolar disorder. The results showed an increased risk of suicide attempts before treatment initiation, and a smaller but still increased risk after treatment initiation. However, the use of lithium and antiepileptics was associated with a lower risk, while the risk decreased with antipsychotics. Therefore, the study suggests that mood stabilizing agents are not causally associated with an increased risk of suicide attempts, and lithium and antiepileptics may have potential protective effects. Assiduous monitoring of symptoms relapse and warning signs of suicide should be part of the management plan.
PSYCHIATRY RESEARCH
(2023)
Correction
Infectious Diseases
Iain A. Gillespie, Eleanor Barnes, Ian C. K. Wong, Philippa C. Matthews, Graham S. Cooke, Craig Tipple, Robert C. Elston, Yunhao Liu, David A. Smith, Tingyan Wang, Jim Davies, Kinga A. Varnai, Oliver Freeman, Kenneth K. C. Man, Wallis C. Y. Lau, Ben Glampson, Xing Meng, Eleonora Morais, Sen Liu, Luca Mercuri, Naomi Boxall, Sarah Jenner, Stuart Kendrick, Jane Dong, Dickens Theodore
INFECTIOUS DISEASES AND THERAPY
(2023)