Article
Ecology
Landon R. Jones, Robert K. Swihart, David F. Gleich, Geriann Albers, Scott A. Johnson, Cassie M. Hudson, Patrick A. Zollner
Summary: This study extended the use of Maximum clique analysis (MCA) to assess landscape carrying capacity for a population of female bobcats. The researchers incorporated uncertainty into their estimates and compared different algorithms for large-scale areas. The results showed that MCA can be an effective method for assessing wildlife population and landscape capacity while accounting for uncertainty.
Article
Environmental Sciences
Lu Xu, Chunxiao Wang, Ning Ba, Yu Hao
Summary: As urbanization progresses, the increasing number of resource and environmental problems poses challenges to sustainable growth in cities. The Urban Resource and Environment Carrying Capacity (URECC) is a crucial indicator for understanding the interaction between human activities and urban resource and environmental systems, guiding sustainable urban development. It is essential to accurately comprehend and analyze the URECC and coordinate the balanced growth of the economy and the URECC to ensure cities' sustainable development.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Cao Thi Thu Trang, Trinh Thanh, Tran Duc Thanh, Vu Duy Vinh, Tran Anh Tu
Summary: Tam Giang-Cau Hai lagoon is the largest lagoon in Viet Nam, receiving a large amount of wastewater pollution each year, causing adverse effects on aquatic life. The study suggests that building wastewater treatment plants is an important measure to reduce pollution load in the lagoon.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Civil
Liting Wang, Weihua Zeng, Ruoxin Cao, Yue Zhuo, Jie Fu, Jianping Wang
Summary: Water environment-water resources carrying capacity (WERCC) is a significant sustainability indicator for measuring water systems. Traditional methods for calculating water environment carrying capacity (WECC) tend to focus on deterministic results. However, WERCC, WECC, and water resources carrying capacity (WRCC) are random variables with certain probability distributions. In order to address this, a Bayesian network-based WERCC overloading risk assessment method was established to calculate the water system carrying state and its probability by determining the WECC and WRCC probability distributions.
JOURNAL OF HYDROLOGY
(2023)
Article
Engineering, Civil
Jiaxi Chen, Xiaonan Tang
Summary: Water is a crucial resource for sustainable development in cities. Evaluating water environment carrying capacity is important for wise water resources management. This study developed an evaluation index system for Suzhou, and found that water environment carrying capacity has improved over time despite challenges from rapid urbanization, population growth, and water shortage. The findings contribute to the city's sustainable development planning.
WATER RESOURCES MANAGEMENT
(2023)
Article
Oncology
Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Xiang Weng, Shruti Sharma, Pallavi Awate, Zhiyi Liu, Dong Gao, Nicholas Mitsiades, Joseph H. Schwab, Yu Chen, Rinath Jeselsohn, Aedin C. Culhane, Myles Brown, Irene Georgakoudi, Constantine S. Mitsiades
Summary: This study reveals the previously underappreciated dependency of tumor cells on HR signaling for anchorage-independent growth and how the metastatic microenvironment restores this malignant property of cancer cells during hormone therapy. The research showed distinct mechanisms of hormone-independent growth and hormone therapy resistance induced by bone marrow stromal cells in breast and prostate cancer cell cultures. Understanding these mechanisms could help refine treatment approaches for hormone therapy-resistant patients with metastatic tumors.
Article
Construction & Building Technology
Jingyang Zhou, Shasha Chang, Wenqiu Ma, Danyang Wang
Summary: The paper focuses on studying the unbalance characteristics that need to be met when evaluating the carrying capacity of urban resources and environment. It provides a specific conceptual framework and steps for sustainable development of cities.
SUSTAINABLE CITIES AND SOCIETY
(2021)
Article
Multidisciplinary Sciences
Bente Holm, Stephan Barsuhn, Hans-Michael Behrens, Sandra Krueger, Christoph Roecken
Summary: This study explored the expression and correlation of RNF43 and LRP1B with clinicopathological characteristics in gastric cancer. The expression of RNF43 and LRP1B was significantly correlated with the Lauren phenotype and with each other. Furthermore, differential effects of RNF43 expression were observed between intestinal and diffuse type gastric cancers. These findings suggest that the expression and biological effects of RNF43 and LRP1B in gastric cancer are context-dependent.
SCIENTIFIC REPORTS
(2023)
Article
Economics
Han Zhang, Jinhui Zheng, Ahmed Imran Hunjra, Shikuan Zhao, Elie Bouri
Summary: By examining the impact mechanism and threshold effect of urban land use efficiency (ULUE) on resources and environment carrying capacity (RECC), this study finds that improving ULUE can enhance RECC and plays an important role in the rationalization and advancement of industrial structure. The study also reveals significant differences in the impact of ULUE on RECC across regions, periods, administrative levels, and resource endowments.
SOCIO-ECONOMIC PLANNING SCIENCES
(2024)
Article
Environmental Sciences
Hong Huang, Zuanyi Wang, Yingdong Li, Xu Zhao, Zhenhua Wang, Xiaopeng Cheng
Summary: This study proposed an evaluation method for the carrying capacity of fishery resources and ecological environment and analyzed the coupling coordination degree between them based on investigation data in Dachen Islands. The results showed that the islands were in a critical overload state, with significant fluctuations among seasons.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Environmental Sciences
Guanzheng Hu, Weihua Zeng, Ruihua Yao, Yuxi Xie, Sai Liang
Summary: The study establishes a dynamic system model with five subsystems and an overarching parent system to assess the carrying capacity of water environments. The results show that by 2025, the carrying rates for water environment and resources will decrease, while the water ecology carrying rate will remain high.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Biodiversity Conservation
Chao Bao, Hongjie Wang, Siao Sun
Summary: This study constructs a comprehensive RECC indicator and a system dynamics model to evaluate the resources and environment carrying capacity of the Beijing-Tianjin-Hebei urban agglomeration, providing recommendations for its future development.
ECOLOGICAL INDICATORS
(2022)
Article
Environmental Sciences
Shukui Tan, Qi Liu, Siyu Han
Summary: The study found that as land development intensity increases, the carrying capacity of resources environment shows different types of changes; the proportion of construction land, GDP per land, and population density are the main determinants of land development intensity, while water resources, energy consumption, and per capita cultivated land are the main determinants of resources environment carrying capacity; the coupling and coordination relationships have continuously strengthened over time, while the spatial evolution has shown a narrowing inter-regional gap.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Environmental Studies
Jiawei Qi, Yichen Zhang, Jiquan Zhang, Yanan Chen, Chenyang Wu, Chenyu Duan, Zhongshuai Cheng, Zengkai Pan
Summary: In this study, the geological environment carrying capacity of two districts in Tonghua City, Jilin Province was evaluated. A total of 14 evaluation indicators were selected to comprehensively evaluate the carrying capacity of the geological environment. The overall carrying capacity of the geological environment in the study area is good, but there are some areas with poor carrying capacity.
Article
Green & Sustainable Science & Technology
Yuanmin Wang, Mingkang Yuan, Xiaofeng Zhou, Xiaobing Qu
Summary: This study introduces the intuitionistic fuzzy multi-attribute decision-making method into the evaluation of geo-environmental carrying capacity. Using Meishan, China as an example, it establishes a complete analysis framework and classifies the evaluation into five grades. The results show spatial differences and uneven distribution in geo-environmental carrying capacity, with average annual rainfall and degree of karst development being the main influencing factors. These findings can provide technical support for urban planning, regional sustainable development, and ecological environmental protection.
Letter
Multidisciplinary Sciences
Haoxuan Liu, Jianzhi Zhang
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Piaopiao Chen, Agnes H. Michel, Jianzhi Zhang
Summary: Epistasis can lead to drastically different phenotypic consequences of the same mutation in different individuals. Gene essentiality changes tend to occur concordantly among components of the same protein complex or metabolic pathway and among a group of over 100 mitochondrial proteins, revealing molecular machines or functional modules as units of gene essentiality variation.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Debora Y. C. Brandt, Xinzhu Wei, Yun Deng, Andrew H. Vaughn, Rasmus Nielsen
Summary: This study compared the estimates of coalescence times from three ancestral recombination graph inference programs using standard neutral coalescent simulations. The results showed that ARGweaver had the most accurate estimates at each locus, while Relate was often more accurate than tsinfer+tsdate. However, all three methods tended to overestimate small coalescence times and underestimate large ones. The posterior distribution of ARGweaver was closer to the expected distribution compared to Relate, but it sacrificed scalability.
Article
Biochemistry & Molecular Biology
Haoxuan Liu, Jianzhi Zhang
Summary: This study challenges the theory that mutations are blind to their consequences by finding that the plant Arabidopsis thaliana has lower mutation rates in genomic regions where mutations are more likely to be deleterious. However, further analysis of mutational data from baker's yeast and humans does not support this finding. The study also suggests that the extra mutations detected in Arabidopsis may be sequencing errors.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Xukang Shen, Siliang Song, Chuan Li, Jianzhi Zhang
Summary: Synonymous mutations in protein-coding genes are not neutral and often result in reduced fitness and disturbed mRNA expression levels. Non-synonymous mutations have greater fitness variations across environments, which may explain the lower substitution rates compared to synonymous mutations.
Review
Genetics & Heredity
Jianzhi Zhang
Summary: Genomics, a interdisciplinary field of biology, has revolutionized various subdisciplines of life sciences by providing large amount of data, introducing high-throughput technologies, and offering new approaches to biology. In this review, the author describes what they have learned from genomics, mainly focusing on variation, interaction, and selection, which are central topics in evolutionary biology. The author expects that the most important contributions of genomics to evolutionary biology in the future will include providing genome sequences of almost all known species on Earth, facilitating high-throughput phenotyping of natural variants and mutants, and assisting in the determination of causality in evolutionary processes using experimental evolution.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Siliang Song, Jianzhi Zhang
Summary: Because human same-sex sexual behavior is heritable and leads to fewer offspring, it is puzzling why these alleles have not been purged. The antagonistic pleiotropy hypothesis suggests that these alleles benefit individuals performing opposite-sex sexual behavior. However, our analysis of the UK Biobank data shows that having more sexual partners no longer predicts more offspring, and same-sex behavior is genetically negatively correlated with the number of offspring, indicating a loss of genetic maintenance in modern societies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Haiqing Xu, Chuan Li, Chuan Xu, Jianzhi Zhang
Summary: The functional significance of pervasive intergenic transcription from eukaryotic genomes is debated. This study shows that only a small fraction (1-5%) of yeast intergenic transcription is unrelated to chance promoter activity or neighboring gene expression.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Haoxuan Liu, Jianzhi Zhang
NATURE COMMUNICATIONS
(2023)
Article
Biology
Xinzhu Wei, Christopher R. Robles, Ali Pazokitoroudi, Andrea Ganna, Alexander Gusev, Arun Durvasula, Steven Gazal, Po-Ru Loh, David Reich, Sriram Sankararaman
Summary: Through analyzing the genetic data of 300,000 individuals and 96 distinct phenotypes, it is found that the genetic variants introduced from interbreeding with Neanderthals have a modest contribution to complex human traits. However, these introgressed variants tend to be depleted compared to modern human variants, possibly due to purifying selection. The significant associations between introgressed Neanderthal variants and phenotypes are likely driven by nearby modern human variants rather than the introgressed variants themselves.
Article
Biochemistry & Molecular Biology
Daohan Jiang, Alexander L. Cope, Jianzhi Zhang, Matt Pennell
Summary: Variation in gene expression across lineages plays a crucial role in explaining phenotypic variation and adaptation. However, the assumption that mRNA levels can accurately represent protein levels has been challenged by studies showing weak correlations between the two measures across species. This discrepancy might be due to compensatory evolution between mRNA levels and translation regulation, but the conditions and strength of the correlation are still not well understood. A theoretical model of the coevolution of mRNA and protein levels reveals that compensatory evolution is common with stabilizing selection on protein levels, while under directional selection, mRNA levels and translation rates show negative correlations across lineages but positive correlations across genes. These findings offer insights into comparative studies of gene expression and provide a framework to distinguish biological and statistical hypotheses for the transcriptomic-proteomic mismatch.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Biology
Haoxuan Liu, Mengyi Sun, Jianzhi Zhang
Summary: The latitudinal diversity gradient (LDG) is the decrease in biodiversity from the equator to the poles. Previous studies have suggested that this gradient is driven by differences in nucleotide mutation and substitution rates related to temperature. However, analysis of genomic data does not support this hypothesis. Instead, there is a significant negative association between the nonsynonymous substitution rate and temperature, indicating that the demand for protein stability at higher temperatures leads to a higher fraction of detrimental mutations.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Genetics & Heredity
Siliang Song, Jianzhi Zhang
Summary: The natural environment fluctuates, affecting the fitness of organisms. The commonly used measure of geometric mean fitness may be misleading due to genetic drift. In this study, a new measure called effective fitness is proposed, which captures the overall effect of fluctuating selection more accurately by considering average expected allele frequency change caused by selection.
G3-GENES GENOMES GENETICS
(2023)
Article
Multidisciplinary Sciences
Piaopiao Chen, Jianzhi Zhang
Summary: This study analyzed transcriptomic data from multiple species and found that genetic assimilation of environment-induced gene expression is not common, with most genes retaining their expression plasticity after organisms adapt to new environments.
Biographical-Item
Ecology
Jianzhi Zhang, Sudhir Kumar
Summary: He is an evolutionary geneticist who revolutionized evolutionary biology through powerful statistical methods in molecular research.
NATURE ECOLOGY & EVOLUTION
(2023)