Article
Biochemistry & Molecular Biology
Yalei Liu, Jie Mao, Zhiyong Guo, Yufang Hu, Sui Wang
Summary: The authors prepared a bifunctional hydrogel with antibacterial and self-healing properties by cross-linking polyvinyl alcohol and carboxymethyl chitosan through hydrogen bonds and borate ester bonds. The hydrogel showed improved mechanical properties and the addition of silver nanoparticles effectively inhibited bacterial growth, providing potential applications in biological wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Sudan Liu, Diansen Li, Yu Wang, Guoqiang Zhou, Kun Ge, Lei Jiang
Summary: A double crosslinked hydrogel was prepared using carboxylated polyvinyl alcohol (PC) and chitosan (CS)/Fe3+, which showed excellent swelling ratio, biodegradability, mechanical strength, and adhesion properties. It also demonstrated antibacterial activity, hemostatic capacity, and promoted skin healing by angiogenesis and collagen deposition. Therefore, the double crosslinked hydrogel is a promising dressing for dynamic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Meng Zhang, Guohui Wang, Dong Wang, Yuqi Zheng, Yanxin Li, Wenqiao Meng, Xin Zhang, Feifan Du, Shaoxiang Lee
Summary: This study successfully prepared a bilayer composite dressing for wound healing, with the upper layer possessing antibacterial activity and the lower layer having biocompatibility, the combination of which showed synergistic antibacterial effects and could accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Biochemistry & Molecular Biology
Hengji Zhao, Yushu Zhang, Chao Zhou, Chunling Zhang, Bo Liu
Summary: Natural polysaccharide-based hydrogels provide effective skin protection during trauma and exhibit good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jianrui Qi, Jie Zhang, Hang Jia, Xinyuan Guo, Yuan Yue, Yahong Yuan, Tianli Yue
Summary: This study successfully developed a low-cost antibacterial nanobiomaterial with strong antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as good biocompatibility. In vivo assays confirmed that the nanocomposite not only promoted the healing of wound infection caused by bacteria, but also had no toxic effect on mouse organs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Liangfu Zhou, Xixi Zhao, Meixuan Li, Lu Yan, Yao Lu, Chunmei Jiang, Yanlin Liu, Zhongli Pan, Junling Shi
Summary: The study developed a new chitosan composite dressing loaded with iturin-AgNPs, which showed higher antibacterial activity and better promotion of wound healing compared to commercial dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Jie Zhou, Tianjiao Li, Meili Zhang, Bo Han, Tao Xia, Shuangshuang Ni, Zhiyong Liu, Zhenyang Chen, Xing Tian
Summary: The study reports a thermosensitive black phosphorus hydrogel that possesses photothermal and antibacterial treatment capabilities to promote wound healing in a rat skin injury model.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
E. Massarelli, D. Silva, A. F. R. Pimenta, A. Fernandes, J. L. G. Mata, H. Armes, M. Salema-Oom, B. Saramago, A. P. Serro
Summary: A new PVA/Ch based wound dressing was developed, which showed protection, hydration, and controlled release of antiseptics. The dressings exhibited antibacterial activity against S. aureus and S. epidermidis, with the ones loaded with PHMB showing better cytotoxicity and irritability properties. The application of this dressing in wound treatment in a dog led to faster recovery compared to conventional treatment, suggesting its potential as an alternative in wound care.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Mahtab Doostan, Maryam Doostan, Parisa Mohammadi, Kamyar Khoshnevisan, Hassan Maleki
Summary: Impaired wound healing can lead to prolonged wound closure, high infection rate, and disabilities. A PVA/CS nanofibrous scaffold-loaded with flaxseed extract was developed to address this issue. The scaffold demonstrated a nano-scale cross-network structure with high water absorption and porosity. It also showed antioxidant properties and inhibition of bacterial growth, promoting accelerated wound healing in vitro.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Li Mei, Dongjie Zhang, Huarong Shao, Yuanping Hao, Ting Zhang, Weiping Zheng, Yanjing Ji, Peixue Ling, Yun Lu, Qihui Zhou
Summary: Superbacteria-induced skin wound infections are significant health challenges. Probiotic therapy combined with biomimicking hydrogels shows great potential in treating infections and promoting wound repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Hamide Hemati, Fateme Haghiralsadat, Mahdie Hemati, Ghasem Sargazi, Nastaran Razi
Summary: In this study, a nanoliposome-loaded hydrogel scaffold system was proposed for treating skin injuries. The system exhibited high drug entrapment efficiency and gradual drug release characteristics, with low toxicity to human cells, suggesting its potential in wound healing.
Article
Biochemistry & Molecular Biology
Fahad M. Aldakheel, Dalia Mohsen, Marwa M. El Sayed, Khaled Ali Alawam, AbdulKarim S. Binshaya, Shatha A. Alduraywish
Summary: In this study, silver nanoparticle composites were synthesized using green tea leaf extract as a reducing agent and microwave irradiation technology. The AgNPs/chitosan grafted polyvinyl alcohol hydrogel samples were successfully prepared. The antibacterial activity and wound-healing ability of the hydrogel samples were evaluated in vitro and in vivo, and promising results were obtained.
Article
Polymer Science
Ghassan H. Matar, Muberra Andac
Summary: Silver nanoparticles-loaded locust bean gum/polyvinyl alcohol hydrogels with promising antibacterial properties were successfully prepared and characterized. The hydrogels exhibited good antibacterial activity against Gram-negative and Gram-positive bacteria, as confirmed through various characterization techniques. The results suggest that these hydrogels could be a potential candidate for medical applications due to their effective antibacterial properties.
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Public, Environmental & Occupational Health
Hoang Bac Nguyen, Thi Hong Minh Nguyen, Thi Hong Nhan Vo, Thi Cam Nhung Vo, Duc Nguyet Quynh Nguyen, Huu-Thinh Nguyen, Tuan-Ngan Tang, Thi-Hiep Nguyen, Van Trang Do, Quang Binh Truong
Summary: This study investigated PTSD, anxiety, depression, and related factors among COVID-19 patients during the fourth wave of the pandemic in Vietnam. The results showed that family or friends should be the first line of support for mental interventions for COVID-19 patients. The mode of infection, age, education level, and other factors were also associated with psychological responses.
INTERNATIONAL HEALTH
(2023)
Article
Engineering, Biomedical
Khanh L. Ly, Xiaolong Luo, Christopher B. Raub
Summary: Oral mucositis is a common complication in patients with head and neck cancer undergoing chemotherapy and radiation treatment. This study presents a microfluidic model of oral mucositis that mimics the induction and resolution mechanisms of the condition.
Article
Chemistry, Physical
Ngoc Xuan Dat Mai, Thu-Ha Thi Nguyen, Du Huy Nguyen, Linh Ho Thuy Nguyen, Hiep Thi Nguyen, Thang Bach Phan, Fuyuhiko Tamanoi, Long Binh Vong, Tan Le Hoang Doan
Summary: A new type of biodegradable disulfide-based PMO was synthesized and proved to be a potential nanocarrier for improved cancer therapy. The materials showed a fast degradation rate and high drug loading capacity. The released anticancer drug exhibited higher activity against cancer cells compared to the free drug.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Ngoc-Hang Truong-Thi, Ngoc Hoi Nguyen, Dinh Tien Dung Nguyen, Tuan Ngan Tang, Thi Hiep Nguyen, Dai Hai Nguyen
Summary: In this study, a drug delivery system based on mesoporous silica nanoparticles modified with heparin was fabricated to achieve sustainable and pH-responsive release of Platinum-based drugs. The modified nanoparticles showed high uniform spherical shape with a diameter of 89.03 +/- 4.49 nm, and had a loading capacity of cisplatin twice as the bare nanoparticles. The amount of drug released in tumor microenvironment (pH 5.8) was significantly higher than that released in physiological environment (pH 7.4). Cell toxicity assay confirmed the biocompatibility of the modified nanoparticles on MCF-7 cells. These results suggest that the heparin-modified nanoparticles have great potential as nanocarriers for chemotherapy with effectively loading ability and sustained release of Platinum-based drugs with pH response.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Bao Vy Tran, Quang Minh Truong, Lam Que Anh Nguyen, Ngoc My Huong Nguyen, Quang Hung Tran, Thi Tuyet Phuong Dinh, Vinh Son Hua, Van Dung Nguyen, Peter A. Lambert, Thi Thu Hoai Nguyen
Summary: Understanding the colonization of P. aeruginosa in healthy humans is important for future prevention and treatment. This study investigated its prevalence and risk factors in 609 Vietnamese volunteers. It was found that 3.12% of participants were colonized by P. aeruginosa, with a higher likelihood in those with a history of sinusitis.
Article
Materials Science, Textiles
Binh Thanh Vu, Phuc Dang-Ngoc Nguyen, Nam Minh-Phuong Tran, Tuan-Ngan Tang, Thai Minh Do, Toi Van Vo, Hiep Thi Nguyen
Summary: Artificial vascular transplantation is a potential therapy for cardiovascular diseases, which are a leading cause of death worldwide. Researchers have successfully created large-caliber vascular structures through the development of vascular tissue engineering. However, fabricating artificial blood vessels less than 6 mm in diameter remains a challenge. In this study, tubular structures of this size were fabricated from blended polyurethane/polycaprolactone nanofibers coated with anti-thrombogenic agents and lined with endothelial cells. The polymeric structure from these cytocompatible polymers demonstrated suitable physical properties as a vascular graft. Further investigation showed that the conjugated linoleic acid-grafted scaffold supported endothelial proliferation while limiting platelet adhesion. This approach could pave the way for a promising therapeutic method of artificial vascular transplantation that effectively overcomes occlusion.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Ngoc Tuan Nguyen, Thuy Tien Nguyen Tran, Thuy-Kieu Truong, Jianmin Yu, Thong Nguyen-Minh Le, Thang Bach Phan, Tan Le Hoang Doan, Linh Ho Thuy Nguyen, Tin Dai Luong, Thi-Hiep Nguyen, Ngoc Quang Tran
Summary: In this study, a general approach was used to synthesize a hollow ternary metal fluoride (FeCoNiF2) nanoflake array as an efficient and robust bifunctional electrocatalyst for the hydrogen evolution reaction (HER) and urea oxidation reaction (UOR). The F anion was found to withdraw electrons from the metal centers, inducing an electron-deficient metal center catalyst. The hollow FeCoNiF2 nanoflake array exhibited excellent catalytic activity and superior long-term durability for both the HER and UOR.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Andrew-Hieu Nguyen, Khanh L. Ly, Van Khanh Lam, Zhaoyang Wang
Summary: This paper presents a robust 3D shape reconstruction approach integrating a structured-light technique with a deep learning-based artificial neural network. The proposed approach employs a single-input dual-output network capable of accurately determining the unwrapped true phase distributions containing the depth information of the imaging target for subsequent 3D reconstruction process. Numerous experiments have been conducted to assess the proposed technique, and its robustness makes it a promising and much-needed tool for scientific research and engineering applications.
Article
Chemistry, Multidisciplinary
Cao-Hien Nguyen, Kien-Sam Banh, Tran Nguyen Minh An, Nguyen Thi Hong Anh, Chi-Hien Dang, Van-Dat Doan, Tran Thi Kim Chi, Hieu Vu-Quang, Thanh-Danh Nguyen
Summary: The aim of this research is to investigate the influence of different functional groups of b-cyclodextrin (CD) in functionalizing gold nanoparticles for drug delivery. TMACD was found to be the most effective in loading 5-FU and protected the drug with low release percentage. The nanocomposite AuNPs/TMACD exhibited the highest efficacy in suppressing the growth of breast cancer cells.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dinh Trung Nguyen, Thi Phuong Nguyen, Van Thoai Dinh, Ngoc Hao Nguyen, Kim Thi Hoang Nguyen, Thi Hiep Nguyen, Tang Tuan Ngan, Tran Thi Yen Nhi, Bao Ha Tran Le, Phuong Le Thi, Le Hang Dang, Ngoc Quyen Tran
Summary: Dual-drug delivery systems using FA-GP-P123 nanogels show great potential in targeted chemotherapy by simultaneously delivering QU and PTX to tumors, overcoming drug resistance and improving therapeutic efficacy. The nanogels have high drug loading capacity and the release of drugs follows Fickian diffusion and swelling behavior. The FA-GP-P123/QU/PTX system exhibits synergistic effects and FA positive targeting effect, leading to reduced tumor volume and minimized side effects in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Vo Minh Quan, Dat-Quoc Do, Tin Dai Luong, Tuan-Ngan Tang, Binh Thanh Vu, Hien-Phuong Le, Phuc H. Vo, Nhi Ngoc-Thao Dang, Quyen Ngoc Tran, Nhu-Thuy Trinh, Thi-Hiep Nguyen
Summary: Dynamic hydrogel systems from N,O-carboxymethyl chitosan (NOCC) have been extensively studied for their applications in biomedical engineering. However, the effect of polymer's oxidation levels on hydrogel biological properties is not fully understood. This study investigates the use of oxidized xanthan gum (OXG) as a crosslinker for NOCC to create injectable hydrogels with controlled degradability. Different oxidation levels of xanthan gum and NOCC/OXG volume ratios are tested, and the physical and biological properties of the resulting hydrogels are characterized. The findings suggest suitable amounts of oxidized xanthan gum for tissue engineering applications.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Nhi Thao-Ngoc Dang, Nam Minh-Phuong Tran, Hoan Ngoc Doan, Nam Cong-Nhat Huynh, Thien-Ly Vu, Tuan-Ngan Tang, An Tran-My Le, Hai-Ly Tran, Phan Thi Thanh Tam, Phuong-Thao Nguyen, Tram Anh-Nguyen Ngoc, Hanh Ta, Thang Phan, Toi Van Vo, Thi-Hiep Nguyen
Summary: This study investigated the effect of synthetic conditions on the physicochemical properties and the remineralization behaviors of BCP materials in artificial saliva. The results showed that the ratio of HA and β-TCP in BCP increased with the increase of pH during the synthesis process. BCP with the highest β-TCP contents, sintered at 800 degrees C, demonstrated fast neutralization capacity to prevent enamel from dissolving.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Hien-Phuong Le, Thai-Hoang Tran, Dat-Quoc Do, Khanh-Ngoc Trinh-Phan, Le-Giang Tran, Van-Toi Vo, Thi-Hiep Nguyen
Summary: This study improves the physicochemical properties of xanthan gum-based hydrogels by applying periodate oxidation, resulting in enhanced mechanical strength and stability. These hydrogels have great potential as biomaterials for various applications such as drug delivery, cell therapy, or tissue regeneration.
Review
Engineering, Chemical
Ngoc Phuong Uyen Nguyen, Ngoc Tung Dang, Linh Doan, Thi Thu Hoai Nguyen
Summary: Silver nanoparticles, known as AgNPs, have unique characteristics that make them highly researched in the fields of optics, antibacterial, and electronics. In the era of antibiotic crisis, AgNPs are potential candidates as they possess strong antimicrobial activity and synergistic effects when combined with other drugs. The synthesis methods and process greatly influence the properties of AgNPs.
Article
Nanoscience & Nanotechnology
Tuan-Ngan Tang, Thu Hai-Anh Nguyen, Chien Minh Tran, Vinh Khanh Doan, Ngoc Thi-Thanh Nguyen, Binh Thanh Vu, Nhi Ngoc-Thao Dang, Thanh Tu Duong, Viet Hung Pham, Lam Dai Tran, Toi Van Vo, Thi-Hiep Nguyen
Summary: This study successfully fabricated a multilayer wound dressing combining silver nanoparticles and chitosan oligosaccharides. Characterisation tests demonstrated its suitable characteristics, including proper tensile strength, fluid-absorbable inner surface, waterproof outer layer, and controlled release. In vitro experiments showed its haemostatic and antibacterial effects, while in vivo experiments confirmed its positive effects on wound healing.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
