期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 42, 页码 13219-13223出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604429
关键词
cross-coupling; nickel catalysis; photocatalysis; radical reactions; synthetic methods
资金
- AstraZeneca (Oncology and Innovative Medicine)
- AstraZeneca Innovative Medicines and Early Development Graduate Programme
A visible-light-promoted iridium photoredox and nickel dual-catalyzed cross-coupling procedure for the formation C-N bonds has been developed. With this method, various aryl amines were chemoselectively cross-coupled with electronically and sterically diverse aryl iodides and bromides to forge the corresponding C-N bonds, which are of high interest to the pharmaceutical industries. Aryl iodides were found to be a more efficient electrophilic coupling partner. The coupling reactions were carried out at room temperature without the rigorous exclusion of molecular oxygen, thus making this newly developed Ir-photoredox/Ni dual-catalyzed procedure very mild and operationally simple.
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