期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 10, 页码 3300-3303出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201512032
关键词
1; 5-benzothiazepine; asymmetric hydrogenation; N-heterocyclic carbenes; ruthenium; vinylthioethers
资金
- Alexander von Humboldt Foundation
- Deutsche Forschungsgemeinschaft
A novel asymmetric hydrogenation of vinylthioethers was developed using a ruthenium(II) NHC complex. This method provides an efficient approach to optically active 1,5-benzothiazepines featuring stereocenters with C-S bonds. Excellent enantioselectivities (up to 95%ee) and high yields (up to 99%) were obtained for a variety of substrates bearing a range of useful functional groups. Moreover, this methodology could be directly applied to the synthesis of the antidepressant drug R-(-)-thiazesim.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据