期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 38, 页码 11591-11594出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605189
关键词
allenoates; bifunctional phosphines; domino reaction; poly-heterocycle rings; sequential annulations
资金
- National Natural Science Foundation of China [21472097, 21172115]
- Natural Science Foundation of Tianjin [15JCYBJC20000]
- Research Fund for the Doctoral Program of Higher Education of China [20120031110002]
A highly stereoselective sequential annulation reaction between -substituted allenoates and ketimines was reported. By using bifunctional N-acyl aminophosphine catalysts, poly-heterocycle rings were obtained with high stereocontrol in good to excellent yields. The desired products have four contiguous stereogenic centers (one quaternary and three tertiary carbon centers), and only one isomer was obtained in all reactions.
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