期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 48, 页码 15100-15104出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608198
关键词
alkenes; heterocycles; medium-ring systems; radicals; synthetic methods
资金
- National Natural Science Foundation of China [21572096, 21302088]
- Shenzhen overseas high level talents innovation plan of technical innovation project [KQCX20150331101823702]
A novel radical 1,2-formylfunctionalization of alkenes involving 1,2(4,5)-formyl migration triggered by addition of various carbon- and heteroatom-centered radicals to alkenes has been developed for the first time, thus providing straightforward access to diverse beta-functionalized aldehydes with good efficiency, remarkable selectivity, and excellent functional group tolerance. Analogous transformations mediated by a keto-carbonyl migration have also been effected under similar conditions. This method was used to access ring systems including various benzannulated nine-, ten-, and eleven-membered rings, complex 6-5(6,7)-6(5) fused rings, and bridged rings with diverse functionalities.
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