Programming of Stress-Sensitive Neurons and Circuits by Early-Life Experiences

Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene

(2018) Jessica L. Bolton et al.   BIOLOGICAL PSYCHIATRY

Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress

(2018) Angela Guadagno et al.   Brain Structure & Function

Prenatal maternal mood patterns predict child temperament and adolescent mental health

(2018) Laura M. Glynn et al.   JOURNAL OF AFFECTIVE DISORDERS

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

(2018) Sylvie L Lesuis et al.   Translational Psychiatry

Adverse Early Life Environment Induces Anxiety-like Behavior and Increases 2 Expression of FKBP5 mRNA Splice Variants in Mouse Brain

(2018) Xingrao Ke et al.   PHYSIOLOGICAL GENOMICS

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response

(2018) Jan M. Deussing et al.   PHYSIOLOGICAL REVIEWS

FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats

(2017) Jingjing Xu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience

(2017) A Singh-Taylor et al.   MOLECULAR PSYCHIATRY

Genomic and epigenomic mechanisms of glucocorticoids in the brain

(2017) Jason D. Gray et al.   Nature Reviews Endocrinology

Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity?

(2017) Megan M. Curran et al.   PLoS One

Exposure to unpredictable maternal sensory signals influences cognitive development across species

(2017) Elysia Poggi Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

(2017) Catherine J. Peña et al.   SCIENCE

Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential

(2017) Claire-Dominique Walker et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Stress and Seizures: Space, Time and Hippocampal Circuits

(2017) B.G. Gunn et al.   TRENDS IN NEUROSCIENCES

Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure

(2017) Miranda van Bodegom et al.   Frontiers in Cellular Neuroscience

An Integrated Neuroscience Perspective on Formulation and Treatment Planning for Posttraumatic Stress Disorder

(2017) David A. Ross et al.   JAMA Psychiatry

Oxytocin in General Anxiety and Social Fear: A Translational Approach

(2016) Inga D. Neumann et al.   BIOLOGICAL PSYCHIATRY

MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity

(2016) Jenny Molet et al.   HIPPOCAMPUS

Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice

(2016) J D Gray et al.   MOLECULAR PSYCHIATRY

Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress

(2016) J. Marit Arp et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity

(2016) Marion Schwaiger et al.   NEUROPSYCHOPHARMACOLOGY

Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome

(2016) J Molet et al.   Translational Psychiatry

Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression

(2016) J Posner et al.   Translational Psychiatry

The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion

(2016) Moshe Szyf et al.   Translational Behavioral Medicine

Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3

(2015) B. Jurek et al.   JOURNAL OF NEUROSCIENCE

Epigenetic and transgenerational reprogramming of brain development

(2015) Tracy L. Bale   NATURE REVIEWS NEUROSCIENCE

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

(2015) Torsten Klengel et al.   NEURON

Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

(2015) Yuncai Chen et al.   NEUROPSYCHOPHARMACOLOGY

Stress Effects on Neuronal Structure: Hippocampus, Amygdala and Prefrontal Cortex

(2015) Bruce S McEwen et al.   NEUROPSYCHOPHARMACOLOGY

Early Life Stress Effects on Glucocorticoid—BDNF Interplay in the Hippocampus

(2015) Nikolaos P. Daskalakis et al.   Frontiers in Molecular Neuroscience

Childhood abuse is associated with methylation of multiple loci in adult DNA

(2014) Matthew Suderman et al.   BMC Medical Genomics

Factors associated with cognitive achievement in late childhood and adolescence: the Young Lives cohort study of children in Ethiopia, India, Peru, and Vietnam

(2014) Benjamin T Crookston et al.   BMC Pediatrics

Naturalistic rodent models of chronic early-life stress

(2014) Jenny Molet et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring

(2014) Catherine Jensen Peña et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice

(2014) Eva F.G. Naninck et al.   HIPPOCAMPUS

Early-Life Experience, Epigenetics and the Developing Brain

(2014) Marija Kundakovic et al.   NEUROPSYCHOPHARMACOLOGY

A computational and neural model of momentary subjective well-being

(2014) R. B. Rutledge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Mechanisms of Depression

(2014) Eric J. Nestler   JAMA Psychiatry

Early Life Trauma and Attachment: Immediate and Enduring Effects on Neurobehavioral and Stress Axis Development

(2014) Millie Rincón-Cortés et al.   Frontiers in Endocrinology

Early life stress and later health outcomes-findings from the Helsinki Birth Cohort Study

(2013) Mia Eriksson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response

(2013) B. G. Gunn et al.   JOURNAL OF NEUROSCIENCE

Stress-induced metaplasticity: From synapses to behavior

(2013) M.V. Schmidt et al.   NEUROSCIENCE

Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics

(2013) Paul J. Lucassen et al.   TRENDS IN NEUROSCIENCES

How Does a Neuron “know” to Modulate Its Epigenetic Machinery in Response to Early-Life Environment/Experience?

(2013) Carley A. Karsten et al.   Frontiers in Psychiatry

Fragmentation and Unpredictability of Early-Life Experience in Mental Disorders

(2012) Tallie Z. Baram et al.   AMERICAN JOURNAL OF PSYCHIATRY

Postnatal Aversive Experience Impairs Sensitivity to Natural Rewards and Increases Susceptibility to Negative Events in Adult Life

(2012) Rossella Ventura et al.   CEREBRAL CORTEX

The development of the hypothalamic-pituitary-adrenal axis in rhesus monkeys: Effects of age, sex, and early experience

(2012) Hannah Koch et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Neurobiology of resilience

(2012) Scott J Russo et al.   NATURE NEUROSCIENCE

Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge

(2011) Limor Regev et al.   BIOLOGICAL PSYCHIATRY

Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics

(2011) Christine Heim et al.   EXPERIMENTAL NEUROLOGY

Forebrain CRF1 Modulates Early-Life Stress-Programmed Cognitive Deficits

(2011) X.-D. Wang et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory

(2011) Shawn McClelland et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Early Life Programming and Neurodevelopmental Disorders

(2010) Tracy L. Bale et al.   BIOLOGICAL PSYCHIATRY

Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone

(2010) A. Korosi et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

(2010) A. S. Ivy et al.   JOURNAL OF NEUROSCIENCE

Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation

(2010) L Regev et al.   MOLECULAR PSYCHIATRY

Socioeconomic status and the brain: mechanistic insights from human and animal research

(2010) Daniel A. Hackman et al.   NATURE REVIEWS NEUROSCIENCE

Effects of Neonatal Stress and Morphine on Murine Hippocampal Gene Expression

(2010) Sandra E Juul et al.   PEDIATRIC RESEARCH

Translating Scientific Opportunity Into Public Health Impact

(2009) Thomas R. Insel   ARCHIVES OF GENERAL PSYCHIATRY

Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks

(2009) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Early-Life Stress Disrupts Attachment Learning: The Role of Amygdala Corticosterone, Locus Ceruleus Corticotropin Releasing Hormone, and Olfactory Bulb Norepinephrine

(2009) S. Moriceau et al.   JOURNAL OF NEUROSCIENCE

The neuro-symphony of stress

(2009) Marian Joëls et al.   NATURE REVIEWS NEUROSCIENCE

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

The pathways from mother's love to baby's future

(2009) Aniko Korosi   Frontiers in Behavioral Neuroscience

A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress

(2008) Courtney J. Rice et al.   ENDOCRINOLOGY

Epigenetic mechanisms and the transgenerational effects of maternal care

(2008) Frances A. Champagne   FRONTIERS IN NEUROENDOCRINOLOGY

Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

(2008) Elisabeth B. Binder   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress

(2008) D. L. Champagne et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional nurturing behavior in rat dams with limited access to nesting material: A clinically relevant model for early-life stress

(2008) A.S. Ivy et al.   NEUROSCIENCE

Altered Regulation of Gene and Protein Expression of Hypothalamic-Pituitary-Adrenal Axis Components in an Immature Rat Model of Chronic Stress

(2003) S. Avishai-Eliner et al.   JOURNAL OF NEUROENDOCRINOLOGY