期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 39, 页码 12104-12108出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201606947
关键词
chromans; domino reactions; organocatalysis; oxa-Michael addition; para-quinone methides
资金
- European Research Council (ERC) [320493]
An asymmetric organocatalytic domino oxa-Michael/1,6-addition reaction of ortho-hydroxyphenyl-substituted para-quinone methides and isatin-derived enoates has been developed. In the presence of 5 mol% of a bifunctional thiourea organocatalyst, this scalable domino reaction affords 4-phenyl-substituted chromans bearing spiro-connected oxindole scaffolds and three adjacent stereogenic centers in good to excellent yields (up to 98%) and with very high stereoselectivities (up to > 20:1 d.r., > 99 % ee).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据