期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 17, 页码 5282-5285出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600751
关键词
asymmetric synthesis; kinetic resolution; multicomponent reaction; organocatalysis; reaction mechanisms
资金
- National Natural Science Foundation of China [21320102002, 21502202]
- EPFL (Switzerland)
Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselectivities. An enantioselective Ugi four-center three-component reaction of 2-formylbenzoic acids, anilines, and isonitriles was subsequently developed for the synthesis of the same heterocycle. Mechanistic studies indicate that the enantioselectivity results from the dynamic kinetic resolution of the primary Ugi adduct, rather than from the C-C bond-forming process. The resulting heterocycle products are of significant medicinal importance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据