Article
Oncology
P. Bradley, B. M. Bola, H. Balata, A. Sharman, R. Bootan, P. A. J. Crosbie
Summary: This study reports the prevalence of incidental findings in a lung cancer screening program. It found a significant number of extra-pulmonary malignancies, leading to further clinical management and interventions.
Article
Medicine, General & Internal
Lisa Jungblut, Harry Etienne, Caroline Zellweger, Alessandra Matter, Miriam Patella, Thomas Frauenfelder, Isabelle Opitz
Summary: This pilot study in Switzerland assesses the implementation and performance of low-dose CT lung cancer screening and explores its potential impact on reducing mortality rates. The study enrolls participants meeting specific criteria and uses LDCT scans for assessment. Preliminary results suggest the feasibility of LDCT lung cancer screening in Switzerland.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Jingmin Yuan, Yan Sun, Ke Wang, Zhiyi Wang, Duo Li, Meng Fan, Xiang Bu, Mingwei Chen, Hui Ren
Summary: This study provides the optimal lung cancer screening strategy in China based on cost-effectiveness analysis. The results suggest that starting screening at 50 years old can achieve the maximum net health benefits for heavy smokers.
CANCER PREVENTION RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihui Du, Grigory Sidorenkov, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Marcel J. W. Greuter, Geertruida H. de Bock
Summary: Lowering the screening starting age from 55 to 50 years increases the risk of radiation-induced lung cancers in women by 50%. However, the benefits of LDCT lung cancer screening still outweigh the assumed radiation harm.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Anton Schreuder, Onno M. Mets, Cornelia M. Schaefer-Prokop, Colin Jacobs, Mathias Prokop
Summary: The study suggests that conducting three additional annual CT screening rounds in the National Lung Screening Trial may lead to substantial reduction in lung cancer mortality, with earlier diagnosis of lung cancer patients compared to original screening methods.
Article
Oncology
Andrew M. D. Wolf, Kevin C. Oeffinger, Tina Ya-Chen Shih, Louise C. Walter, Timothy R. Church, Elizabeth T. H. Fontham, Elena B. Elkin, Ruth D. Etzioni, Carmen E. Guerra, Rebecca B. Perkins, Karli K. Kondo, Tyler B. Kratzer, Deana Manassaram-Baptiste, William L. Dahut, Robert A. Smith
Summary: Lung cancer is the leading cause of cancer-related deaths and years of life lost in the US. Early detection through screening has been shown to reduce mortality. The American Cancer Society has updated its guidelines for lung cancer screening, recommending annual low-dose CT screening for individuals aged 50-80 who currently smoke or formerly smoked and have a significant smoking history.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Zheng Su, Xuebing Li, Heng Wu, Zhaowei Meng, Yang Li, Hongli Pan, Hao Liang, Ying Wang, Fang-Hui Zhao, Youlin Qiao, Qinghua Zhou, Ya-Guang Fan
Summary: Lung cancer screening provides an opportunity for smoking cessation and relapse prevention. This study found that non-smokers with negative screening results were more likely to start smoking, while current smokers who attended multiple screenings had a significantly reduced chance of quitting smoking. Factors such as age, gender, occupational exposure, income, and smoking pack years were also associated with smoking behavior changes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Hyun Yoon, Yong Ju Kim, Kibbeum Doh, Junghoon Kim, Kyung Hee Lee, Kyung Won Lee, Jihang Kim
Summary: This study assessed interobserver agreement in Lung-RADS categorisation of subsolid nodules in low-dose screening CTs, showing higher concordance among experienced thoracic radiologists. Overall, the interobserver agreement was moderate.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Gianluca Milanese, Stefano Sestini, Federica Sabia, Colin Jacobs, Bram van Ginneken, Mathias Prokop, Cornelia M. Schaefer-Prokop, Alfonso Marchiano, Nicola Sverzellati, Ugo Pastorino
Summary: This study analyzed the distribution of Lung-RADS v1.1 volumetric categories and lung cancer outcomes within 3 years in order to explore personalized algorithm for lung cancer screening. It found that nodule volume was a strong predictor of lung cancer risk and personalized screening algorithm by increased interval seems feasible in 80% of NLST eligible participants.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyungjin Kim, Hyae Young Kim, Jin Mo Goo, Yeol Kim
Summary: The study validated and compared the performance of the Brock model and Lung-RADS in detecting nodules on baseline CT scans. Both models showed high discrimination but poor calibration performance. The study concluded that Lung-RADS, with visual assessment-based categories, has similar diagnostic performance to the Brock model.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth O'Dwyer, Darragh F. Halpenny, Michelle S. Ginsberg
Summary: This study aimed to determine the rate of SPLC in individuals with a history of cancer undergoing LDCT lung cancer screening, finding a higher occurrence rate than previously reported. The results suggest the need for further research to evaluate the potential mortality benefit of screening in this population.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Soon Ho Yoon, Gong Yong Jin, Jaeyoun Yi, Yeol Kim
Summary: This study evaluated the variability in computer-assisted interpretation of LDCTs among radiologists in a nationwide lung cancer screening program. The results showed significant differences in positive rates and variability between institutional readings and central reviews, indicating that the different usage of computer-assisted systems is a major factor in inter-institution variability.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
R. Edward Hendrick, Robert A. Smith
Summary: Based on the data from three lung cancer screening trials, the benefit-to-radiation-risk ratios are favorable. Modern CT technologies, low diagnostic follow-up rates, and minimizing radiation doses are crucial for successful lung cancer screening practices.