期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 28, 页码 8058-8061出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601559
关键词
cooperative effects; heterogeneous catalysis; Lewis acid; nanoparticles; Rh catalysis
资金
- Japan Society for the Promotion of Science (JSPS)
- Global COE Program
- University of Tokyo
- Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT, Japan)
- Grants-in-Aid for Scientific Research [16H01132, 15H05698] Funding Source: KAKEN
Cooperative catalysts consisting of chiral Rh/Ag nanoparticles and Sc(OTf)(3) have been developed that catalyze asymmetric 1,4-addition reactions of arylboronic acids with alpha,beta-unsaturated amides efficiently. The reaction has been considered one of the most challenging reactions because of the low reactivity of the amide substrates. The new catalysts provide the desired products with outstanding enantioselectivities (>98% ee) in the presence of low loadings (< 0.5 mol%) of the catalyst.
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