期刊
ACS MACRO LETTERS
卷 8, 期 3, 页码 310-314出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.9b00020
关键词
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资金
- National Nature Science Foundation of China [21774030, 21425311, 81772378]
- Key Project of Military Logistics [BWS13C014-1]
- Key Project of Military Medical Technology Innovation Program [SWH2016JSZD-01, SWH2017JCZD-02]
We exploit the thiol-aldehyde addition (TAA) reaction to build a dynamic covalent cross-linking (DCC) hydrogel in the physiological-pH environment. Due to the rapid and reversible TAA reaction, the resulting hydrogels are readily adapted for convenient manipulation, for example, free molding, easy injection, and self-healing. Meanwhile, the labile hemithioacetal bonds within the DCC hydrogel can convert to thermodynamically stable bonds via spontaneous thiol transfer reactions, thereby realizing poststabilization as needed. The successful application as a long-term scaffold for repair of barely self-healed bone defect indicated the hydrogels with both adaptability and mechanical stability based on thiol-aldehyde addition reaction is significant for biomedical areas.
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