期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 13, 页码 4317-4321出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201512020
关键词
arylation; carboxylic acids; palladium; quinoline ligand; -C-H activation
资金
- Scripps Research Institute
- NIH (NIGMS) [2R01GM084019]
- Novartis
Pd-II-catalyzed arylation of -C(sp(3))-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various -aryl--amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.
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