Review
Cell Biology
Xiaochun Liu, Tingting Li, Jia Zhang, Xiling Lin, Wenzhen Wang, Xiaodong Fan, Lili Wang
Summary: The use of mesenchymal stem cells (MSCs) for treating stress urinary incontinence (SUI) shows promise in improving patients’ quality of life. However, the underlying mechanisms of action remain unclear, necessitating further clinical trials. Future studies should focus on designing trials to determine treatment indications, cell dosage, optimal surgical strategies, and develop animal models to better understand the molecular mechanisms behind MSC therapies for SUI improvement.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Mehmet Murat Seval, Kazibe Koyuncu
Summary: Stem cells have the potential to be used in regenerative medicine for treating lower urinary tract dysfunction and stress urinary incontinence. However, further research and validation are needed for clinical applications of stem cell therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Florian A. Schmid, J. Koudy Williams, Thomas M. Kessler, Arnulf Stenzl, Wilhelm K. Aicher, Karl-Erik Andersson, Daniel Eberli
Summary: Urinary incontinence is a major global health issue affecting over 400 million people worldwide. Stress urinary incontinence is the most prevalent subtype, primarily caused by pregnancy, childbirth, and pelvic trauma. Current treatments include physiotherapy, behavioral changes, and surgery, but alternative, minimally invasive options are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xiao-xiao Wang, Lei Zhang, Ye Lu
Summary: Stress urinary incontinence is a common condition in women that has negative impacts on both their physical and mental health, as well as imposing significant socioeconomic pressure. Current conservative treatments have limited effectiveness and rely heavily on patient persistence and compliance. Surgical treatments often come with complications and higher costs. Therefore, it is important to better understand the molecular mechanisms underlying stress urinary incontinence and develop new treatment methods.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Guobing Zhuang, Yan Wen, Mason Briggs, Qingchun Shao, Darlene Tran, Hongbo Wang, Bertha Chen
Summary: The study demonstrates the paracrine effects of human smooth muscle cell progenitors derived from pluripotent stem cells on stress urinary incontinence rodents. The conditioned media from these cells improved urethral leak point pressure and collagen and elastin content in the SUI rat, suggesting a potential therapeutic approach for SUI and related pelvic floor disorders.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Jun Tian, Xiaoxing Kou, Runci Wang, Huan Jing, Chider Chen, Jianxia Tang, Xueli Mao, Bingjiao Zhao, Xi Wei, Songtao Shi
Summary: This study reveals a previously unknown role of autophagy in regulating MSCT therapy via exosomal miRNA Mir7k.
Review
Biotechnology & Applied Microbiology
Zibin Liu, Fang Zeng, Yao Zhang, Yongqing Liu, Zhuo Li, Xiao Liu
Summary: With the aging population growing, the number of patients with retinal degeneration causing vision loss is also increasing. Stem cell therapies offer hope for regeneration and repair of damaged retinal tissue, while exosomes derived from stem cells could be a novel cell-free therapeutic strategy in regenerative medicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Rahel Nardos, Laura Jacobson, Bharti Garg, L. Lewis Wall, Alice Emasu, Bonnie Ruder
Summary: Even after successful closure of obstetric fistula, women continue to suffer from severe persistent urinary incontinence. The worsening severity of incontinence is associated with a greater negative impact on the quality of life for these women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Urology & Nephrology
Simon Morton, Yasmine Wilczek, Christopher Harding
Summary: Millions of synthetic polypropylene meshes have been used worldwide to manage stress urinary incontinence, but many women have reported life-changing complications. There is a lack of studies, heterogeneity of cohorts, poor long-term follow-up, and insufficient evidence on the effective management of mesh-related complications.
Article
Urology & Nephrology
Yuke Chen, Han Hao, Silu Chen, Xu Chen, Yue Liu, Meng Zhang, Wei Yu, Cheng Shen, Shiliang Wu
Summary: This study aimed to investigate the occurrence rates and risk factors of urgent urinary incontinence (UUI) and stress urinary incontinence (SUI) after robot-assisted radical prostatectomy (RARP). The study found that the occurrence rate of SUI was consistently higher than that of UUI, and almost all patients with UUI also had SUI. The risk factors for UUI and SUI were different.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Medicine, General & Internal
Masha Ben Zvi, Maya Arad Cohen, Matan Friedman, Hadas Ganer Herman, Eran Weiner, Shimon Ginath
Summary: This cross-sectional study aimed to compare the prevalence of urinary symptoms between physically active females and medical staff. The results showed that urinary symptoms were more common in women playing catchball, while there was no significant difference in stress urinary incontinence between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Minghui Jiang, Jiahui Liu, Wenli Liu, Xiaoliang Zhu, Yasmeen Bano, Hongbing Liao, Haiyan Li, Hai-Hong Jiang
Summary: The study showed that BMSC secretome can activate AVW fibroblasts, aiding in the acceleration of recovery from simulated birth trauma-induced SUI in rats.
Review
Surgery
Ziye Huang, Tongxin Yang, Lishi Shao, Bowei Yang, Shunhang Yang, Guang Wang, Pei Li, Jiongming Li
Summary: The study evaluating the efficacy and safety of regenerated cell therapy for stress urinary incontinence in humans found no significant differences in cure rates and effective rates among different cell types in males, while in females, myocytes with fibroblasts and nucleated cells with platelets subgroups showed significantly higher cure rates and effective rates. Regenerated cells may be an ideal method for treating stress urinary incontinence in the future, with nucleated cells with platelets and myocytes with fibroblasts being notably effective. Further confirmation is needed to determine if cell injection therapies offer superior effects.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Obstetrics & Gynecology
Aelia Akbar, Kiang Liu, Erin D. Michos, Linda Brubaker, Talar Markossian, Michael P. Bancks, Holly Kramer
Summary: The study found that the prevalence of stress urinary incontinence and mixed urinary incontinence was significantly lower among black women compared to white women, but no significant differences were noted for Chinese or Hispanic women. There were no racial and ethnic differences in urgency urinary incontinence prevalence after adjusting for covariates. Most women with urinary incontinence reported significant bother regardless of race and ethnicity and urinary incontinence subtype.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Igor Maiborodin, Gennadiy Yarin, Sergey Marchukov, Aleksandra Pichigina, Galina Lapii, Sergey Krasil'nikov, Svetlana Senchukova, Maxim Ryaguzov, Inna Vilgelmi, Maksim Bakarev, Vitalina Maiborodina
Summary: The scientific literature in recent years provides a lot of data on the use of MSCs for urinary incontinence, but an ideal treatment method has not been established. Cell therapy shows promising results in patients and experimental animals, but further optimization and clinical research are necessary. The use of MSCs appears to be a feasible, safe, and effective treatment method for urinary incontinence, but the best application mode is still under investigation.
