Article
Biochemistry & Molecular Biology
Yin-Hua Cheng, Ni-Chin Tsai, Yun-Ju Chen, Pei-Ling Weng, Yun-Chiao Chang, Jai-Hong Cheng, Jih-Yang Ko, Hong-Yo Kang, Kuo-Chung Lan
Summary: For the prevention and treatment of intrauterine adhesion, extracorporeal shockwave therapy (ESWT) and platelet-rich plasma (PRP) transplantation have shown promising effects. These treatments can promote endometrial recovery and angiogenesis, reduce fibrosis, and inhibit inflammatory response. Additionally, in the preventive stage, these treatments can also increase the expression levels of vascular endothelial growth factor and progesterone receptor, while in the therapeutic stage, they can increase the expression levels of progesterone receptor, insulin-like growth factor 1, and interleukin 4.
Article
Cell & Tissue Engineering
Xudong Zhang, Siwen Zhang, Jiarui Qi, Fujie Zhao, Yimeng Lu, Shuyu Li, Shanshan Wu, Pingping Li, Jichun Tan
Summary: In this study, the effects of platelet-rich plasma (PRP) and PDGFBB on the biological activities of menstrual blood-derived stromal cells (MenSCs) were compared. PDGFBB improved the viability, migration, and stemness of MenSCs through the AKT/NF-kappa B signaling pathway. Additionally, PDGFBB enhanced the inhibitory effects of MenSCs-derived exosomes on endometrial fibrosis by inhibiting YAP activity. These findings provide a potential option for improving the efficacy of stem cells in intrauterine adhesion.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Siwen Zhang, Qiyuan Chang, Pingping Li, Xiaoyu Tong, Yi Feng, Xinyao Hao, Xudong Zhang, Zhengwei Yuan, Jichun Tan
Summary: Concentrated MenSC-derived sEVs effectively repaired intrauterine adhesion in rat models, promoting gland and vascular regeneration while reversing endometrial fibrosis. Repeated MenSCs-sEVs transplantations significantly improved endometrial receptivity and pregnancy outcomes without causing hematological or biochemical abnormalities. MenSCs-sEVs safely and effectively enhanced endometrial restoration through inhibition of the TGF beta 1/SMAD3 pathway and upregulation of BMP7 expression.
Article
Cell & Tissue Engineering
Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan, Jichun Tan
Summary: The study found that MenSCs-Exos promoted granulosa cell proliferation in primordial and primary follicles in vitro, restored markers of early follicles, and inhibited follicle apoptosis. In a rat model of POI, transplantation of MenSCs-Exos effectively promoted follicle development, restored estrous cyclicity and hormone levels, and improved live birth outcomes. The findings suggest that MenSCs-Exos transplantation may be a promising treatment for POI with sustained therapeutic effects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Francisca Alcayaga-Miranda, Johnatas Dutra Silva, Nicol Parada, Luisa Helena Andrade da Silva, Fernanda Ferreira Cruz, Yildy Utreras, Yessia Hidalgo, Maria Ignacia Cadiz, Rafael Tapia Limonchi, Francisco Espinoza, Alejandro Bruhn, Maroun Khoury, Patricia R. M. Rocco, Jimena Cuenca
Summary: This study aimed to investigate the impact of cryopreserved MenSCs on ARDS and determine the optimal therapeutic dose, safety, and efficacy. The results showed that clinical-grade cryo-MenSCs can improve lung function, reduce alveolar collapse and tissue cellularity, and modulate inflammatory mediators, promoting angiogenesis and anti-apoptotic effects. The optimal therapeutic dose of 4x10(6) cells/kg was safe and effective, favoring improved lung function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Xin Hang Jin, Yang Li, Dan Li
Summary: A systematic review and network meta-analysis found that platelet-rich plasma (PRP) is the most effective intrauterine intervention for improving pregnancy outcomes in women with two or more implantation failures.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pathology
Gulistan Sanem Saribas, Ozen Akarca Dizakar, Candan Ozogul, Ekin Celik, Mahmut Cerkez Ergoren
Summary: The study aimed to investigate the effect of ellagic acid (EA) on fibrosis in intrauterine adhesion (IUA) model rats and to increase endometrial receptivity. The results showed a decrease in fibrotic structure, down-regulation of TGFβ1 activity, up-regulation of BMP7 activity, and an increase in LIF expression and implantation rates in the EA-treated group compared to the control group. Therefore, it can be concluded that EA treatment reduces fibrosis and increases implantation rates in IUA by promoting uterine tissue healing and enhancing endometrial receptivity.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Medicine, General & Internal
Kwang Beom Lee, Seung Joo Chon, Sunghoon Kim, Dae Yeon Kim, Chan Woo Park, So Jin Shin, Seok Mo Kim, Ki Hwan Lee, Yong Il Ji
Summary: We evaluated the clinical outcomes of using type 1 collagen gel after therapeutic resectoscopy in 150 women aged > 20. The patients were randomly assigned to either the type 1 collagen gel group or the sodium hyaluronate and sodium carboxymethylcellulose gel group. One month after applying anti-adhesive materials, no significant differences were found in the incidence rate and type of postoperative intrauterine adhesions between the two groups. No significant differences in adverse events were noted either. Therefore, type 1 collagen gel can be effectively and safely used in intrauterine surgery to minimize postoperative adhesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chengcheng Xu, Meng Bao, Xiaorong Fan, Jin Huang, Changhong Zhu, Wei Xia
Summary: The aim of this study was to investigate the mechanism of intrauterine adhesion fibrosis and the origin of fibroblasts. The results showed that endothelial cells promote the emergence of fibroblasts via EndMT, playing a key role in the endometrial fibrosis of intrauterine adhesions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Engineering, Multidisciplinary
Yu-Ting Song, Li Dong, Jun-Gen Hu, Peng-Cheng Liu, Yan-Lin Jiang, Li Zhou, Min Wang, Jie Tan, Ya-Xing Li, Qing-Yi Zhang, Chen-Yu Zou, Xiu-Zhen Zhang, Long-Mei Zhao, Rong Nie, Yi Zhang, Jesse Li-Ling, Hui-Qi Xie
Summary: Intrauterine adhesion (IUA) is a major cause of recurrent miscarriage and secondary infertility, characterized by uterine cavity and/or cervical canal obliteration due to endometrial injuries. Tissue engineering technology, using extracellular matrix like small intestine submucosa and stem cells, has shown promise in enhancing endometrial regeneration. In this study, genipin-crosslinked SIS loaded with urine-derived stem cells was used to promote endometrial regeneration and showed positive results both in vitro and in a rat model.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Jiarui Qi, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Shuyu Li, Pingping Li, Jichun Tan
Summary: This study revealed that MenSCs-EXO improved endometrial fibrosis in IUA by regulating the activity of UBR4 and YAP, as well as the expression level of P65. This finding proposes a potential option for the clinical treatment of endometrial injury.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Luyao Feng, Liqun Wang, Yao Ma, Wanglin Duan, Sergio Martin-Saldana, Ye Zhu, Xianpeng Zhang, Bin Zhu, Chaowei Li, Shibo Hu, Mingjie Bao, Ting Wang, Yuan Zhu, Fei Yang, Yazhong Bu
Summary: Intrauterine adhesion (IUA) is a fibrosis condition in the uterus that is the second most common cause of female infertility, adversely affecting women's physical and mental well-being. Current treatment strategies for IUA fail to provide satisfactory outcomes, posing a significant challenge for reproductive science. This study presents a series of self-healing adhesive hydrogels with antioxidant properties (P10G15, P10G20, and P10G25) that exhibit good self-healing, adaptability, injectability, and tissue adhesiveness. In vitro experiments using P10G20 showed effective scavenging of oxidative stress markers and promising biocompatibility. Further, P10G20 demonstrated a reduction in oxidative stress and prevention of IUA with improved tissue regeneration in an animal model, highlighting its potential as a clinical treatment option.
BIOACTIVE MATERIALS
(2023)
Article
Cell & Tissue Engineering
Sining Zhou, Yiming Liu, Qi Zhang, Huikang Xu, Yangxin Fang, Xin Chen, Jiamin Fu, Yin Yuan, Yifei Li, Li Yuan, Charlie Xiang
Summary: In this study, it was found that MenSCs reversed the sorafenib resistance in HCC-SR cells by upregulating the expression levels of BNIP3 and BNIP3L. In addition, MenSCs induced cell death in HCC-SR cells by regulating autophagy and mitochondrial function. Therefore, the combination therapy of sorafenib and MenSCs may be a promising strategy to overcome sorafenib resistance in HCC-SR cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Obstetrics & Gynecology
Ru Zhu, Hua Duan, Wenbin Xu, Sha Wang, Lu Gan, Qian Xu, Jinjiao Li
Summary: A decision tree predictive model was established and validated to predict live birth in patients after surgery for intrauterine adhesions. The study found that postoperative menstrual pattern is a key factor influencing live birth rate.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Huadi Yang, Xuelu Jiang, Ting Chen, Zhitao Yao, Xuqun Xu, Li Wu, Xiaojing Zhu
Summary: By comparing US-HCD technique with traditional hysteroscopic surgery, it was found that US-HCD has significant advantages in terms of operation time and complications, making it a safer, feasible, and more effective treatment for patients with moderate to severe IUA.
Article
Integrative & Complementary Medicine
Li Sun, Zhengwei Yuan, Lingyan Jian, Qinghua Jiang, Siwen Zhang, Jichun Tan
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Medicine, Research & Experimental
Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin, Jichun Tan
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Cell & Tissue Engineering
Siwen Zhang, Boxian Huang, Peng Su, Qiyuan Chang, Pingping Li, Aixin Song, Xinyang Zhao, Zhengwei Yuan, Jichun Tan
Summary: The study found that MenSCs-Exos promoted granulosa cell proliferation in primordial and primary follicles in vitro, restored markers of early follicles, and inhibited follicle apoptosis. In a rat model of POI, transplantation of MenSCs-Exos effectively promoted follicle development, restored estrous cyclicity and hormone levels, and improved live birth outcomes. The findings suggest that MenSCs-Exos transplantation may be a promising treatment for POI with sustained therapeutic effects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Obstetrics & Gynecology
Na Yang, Li Sun, Jichun Tan
Summary: The study determined the current research status of assisted reproductive technology (ART) and birth defects through co-word analysis, revealing that research on the effects of prenatal diagnosis methods and ART on the development of offspring is well developed, while research on reproductive ethics, epigenetics, and epidemiology is relatively immature and needs further exploration.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Genetics & Heredity
Meng Dong, Yanqiang Tao, Shanshan Wu, Lin Kong, Feifei Zhou, Jichun Tan
Summary: This study aimed to explore the perceived changes in sexual behaviour, anxiety symptoms, and couple relationship of patients with infertility during COVID-19 lockdown. Significant differences were found in the changes in sexual behaviour, stress levels, and couple relationship quality among participants with different stress levels. Factors such as sex, anxiety symptoms, decreased sexual satisfaction, sexual activity frequency, and income levels were closely related to couple relationship quality. Pathway analyses indicated that changes in sexual behaviour, anxiety symptoms, and stress levels could all predict the quality of couple relationship.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Meng Dong, Xiaoyan Xu, Yining Li, Yixian Wang, Zhuo Jin, Jichun Tan
Summary: This study found that as the duration of infertility increases, the incidence and severity of psychological depression significantly increases, but there were no significant differences in overall sexual function status. When the infertility duration exceeds 8 years, there is a significant increase in the incidence of sexual dysfunction.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Meng Dong, Shanshan Wu, Xue Zhang, Na Zhao, Jing Qi, Dandan Zhao, Yang Sang, Jichun Tan
Summary: This study found that the vaccination status of both partners in infertile couples, different types of vaccines, and time intervals did not affect embryo quality and pregnancy rates in IVF.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
Meng Dong, Shanshan Wu, Xue Zhang, Na Zhao, Yanqiang Tao, Jichun Tan
Summary: Infertility duration has an impact on the sexual function of men from infertile couples, with decreased erectile function and increased rates of premature ejaculation as the duration increases.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Nanoscience & Nanotechnology
Xinyang Zhao, Siwen Zhang, Shan Gao, Hsun-Ming Chang, Peter C. K. Leung, Jichun Tan
Summary: Tissue engineering advancements allow modification of biomaterials for follicle development and hGC behavior. Hydrogels modified with laminin mimetic peptides in a 3D culture enhance follicle survival, growth, and viability. These peptides improve oocyte meiosis competence and regulate hGCs' biological activity through integrin alpha 6 beta 1 binding.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell & Tissue Engineering
Xudong Zhang, Siwen Zhang, Jiarui Qi, Fujie Zhao, Yimeng Lu, Shuyu Li, Shanshan Wu, Pingping Li, Jichun Tan
Summary: In this study, the effects of platelet-rich plasma (PRP) and PDGFBB on the biological activities of menstrual blood-derived stromal cells (MenSCs) were compared. PDGFBB improved the viability, migration, and stemness of MenSCs through the AKT/NF-kappa B signaling pathway. Additionally, PDGFBB enhanced the inhibitory effects of MenSCs-derived exosomes on endometrial fibrosis by inhibiting YAP activity. These findings provide a potential option for improving the efficacy of stem cells in intrauterine adhesion.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Andrology
Xudong Zhang, Shanshan Wu, Xiaohan Qi, Shan Gao, Jiarui Qi, Siwen Zhang, Jichun Tan
Summary: This study aimed to assess the impact of paternal BMI on assisted reproductive technology (ART) and neonatal outcomes among oligozoospermia and/or asthenospermia patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The study found that higher paternal BMI was associated with reduced success rates of normal fertilization, transferable embryos on day 3, and high-quality embryos in IVF cycles. In terms of neonatal outcomes, paternal BMI was positively associated with the likelihood of macrosomia, large for gestational age (LGA), and very LGA.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Siwen Zhang, Qiyuan Chang, Pingping Li, Xiaoyu Tong, Yi Feng, Xinyao Hao, Xudong Zhang, Zhengwei Yuan, Jichun Tan
Summary: Concentrated MenSC-derived sEVs effectively repaired intrauterine adhesion in rat models, promoting gland and vascular regeneration while reversing endometrial fibrosis. Repeated MenSCs-sEVs transplantations significantly improved endometrial receptivity and pregnancy outcomes without causing hematological or biochemical abnormalities. MenSCs-sEVs safely and effectively enhanced endometrial restoration through inhibition of the TGF beta 1/SMAD3 pathway and upregulation of BMP7 expression.
Article
Environmental Sciences
Shanshan Wu, Min Wang, Yu Deng, Jiahui Qiu, Xinyi Zhang, Jichun Tan
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Developmental Biology
Li Su, Siwen Zhang, Qiyuan Chang, Jichun Tan
REPRODUCTION FERTILITY AND DEVELOPMENT
(2019)