Article
Physics, Multidisciplinary
Maria Guidi, Giovanni Giulietti, Emma Biondetti, Richard Wise, Federico Giove
Summary: Neurovascular alterations play a key role in many brain diseases and can be effectively observed and measured using MRI techniques. The current MRI sequences provide reliable markers for vascular dysfunction, but further research is needed to observe vascular changes at a finer scale.
FRONTIERS IN PHYSICS
(2023)
Article
Biochemical Research Methods
David A. Feinberg, Alexander J. S. Beckett, An T. Vu, Jason Stockmann, Laurentius Huber, Samantha Ma, Sinyeob Ahn, Kawin Setsompop, Xiaozhi Cao, Suhyung Park, Chunlei Liu, Lawrence L. Wald, Jonathan R. Polimeni, Azma Mareyam, Bernhard Gruber, Ruediger Stirnberg, Congyu Liao, Essa Yacoub, Mathias Davids, Paul Bell, Elmar Rummert, Michael Koehler, Andreas Potthast, Ignacio Gonzalez-Insua, Stefan Stocker, Shajan Gunamony, Peter Dietz
Summary: To increase granularity in human neuroimaging science, a next-generation 7 Tesla magnetic resonance imaging scanner was designed and built. It implemented several hardware advancements to improve spatial resolution, image signal-to-noise ratio, and reduce acquisition time.
Article
Neurosciences
Zoltan Nagy, Chloe Hutton, Gergely David, Natalie Hinterholzer, Ralf Deichmann, Nikolaus Weiskopf, S. Johanna Vannesjo
Summary: Sampling the BOLD response with high temporal resolution provides new opportunities to study the functioning of the human brain. This study presents a method that combines a sparse event-related stimulus paradigm with data reshuffling to achieve high temporal resolution while maintaining high signal levels.
Article
Multidisciplinary Sciences
Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee, Jongho Lee, Jeehyun Kwag, Jang-Yeon Park
Summary: Researchers have developed a two-dimensional fast line-scan approach that allows direct imaging of neuronal activity with millisecond precision, while maintaining high spatial resolution. This method was demonstrated in live mouse brain imaging, showing the sequential and laminar-specific propagation of neuronal activity along the thalamocortical pathway.
Article
Endocrinology & Metabolism
Luisa Raimondo, Tomas Knapen, Icaro A. F. Oliveira, Xin Yu, Serge O. Dumoulin, Wietske van der Zwaag, Jeroen C. W. Siero
Summary: Functional magnetic resonance imaging (fMRI) is a widely used tool in neuroscience for detecting neurally evoked responses, such as the blood oxygenation level-dependent (BOLD) signal. Line-scanning fMRI achieves very high spatial resolution and sampling rate, but sacrifices volume coverage. Researchers have successfully implemented line-scanning fMRI in humans, demonstrating potential applications in cognitive and clinical neuroscience.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Avery J. L. Berman, William A. Grissom, Thomas Witzel, Shahin Nasr, Daniel J. Park, Kawin Setsompop, Jonathan R. Polimeni
Summary: A new multi-shot segmented EPI technique (VFA-FLEET-SLR) was developed and demonstrated to achieve clearer fMRI images at high field strengths, showing superior reliability and spatial resolution compared to conventional methods.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Hyun Seok Moon, Haiyan Jiang, Thanh Tan Vo, Won Beom Jung, Alberto L. Vazquez, Seong-Gi Kim
Summary: This study investigated the roles of inhibitory and excitatory activity in the cortex using various methods, revealing different effects on BOLD fMRI between stimulating excitatory neurons and inhibitory neurons, with the latter showing biphasic responses and higher sensitivity to stimulation frequency.
Article
Multidisciplinary Sciences
Hui Xue, Xiaojun Xu, Zhihan Yan, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Guangbin Cui, Quan Zhang, Shijun Qiu, Zhenwei Yao, Wen Qin, Feng Liu, Meng Liang, Jilian Fu, Qiang Xu, Jiayuan Xu, Yingying Xie, Peng Zheng, Wei Li, Caihong Wang, Wen Shen, Xiaochu Zhang, Kai Xu, Xi-Nian Zuo, Zhaoxiang Ye, Yongqiang Yu, Junfang Xian, Chunshui Yu
Summary: This study provides the first unbiased identification of the association between hippocampal BOLD-CBF correlation and genetic factors, revealing significant genes and pathways related to the regulation of different cellular components of the neurovascular unit.
Review
Neurosciences
Michelle Moerel, Essa Yacoub, Omer Faruk Gulban, Agustin Lage-Castellanos, Federico De Martino
Summary: This review highlights the advantages of using ultra-high field MRI in investigating the human auditory system, specifically its ability to study the representation of sound across auditory brain regions and to localize the primary auditory cortex in individual hemispheres. Furthermore, the access to independent signals across auditory cortical depths may lead to a better understanding of the computations underlying the emergence of abstract sound representations. Challenges and promises of studying these research questions using UHF MRI are also discussed, along with a future outlook.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Harm J. van Der Horn, Andrew B. Dodd, Tracey V. Wick, Cidney R. Robertson-Benta, Jessica R. Mcquaid, Anne K. Hittson, Josef M. Ling, Vadim Zotev, Sephira G. Ryman, Erik B. Erhardt, John P. Phillips, Richard A. Campbell, Robert E. Sapien, Andrew R. Mayer
Summary: There is an increasing amount of research suggesting that pediatric mild traumatic brain injury (pmTBI) may lead to cerebral pathophysiological processes that extend beyond the usual clinical recovery timeline. This study used fMRI to examine neural processes related to cognitive control in 181 pmTBI patients at sub-acute and early chronic stages post-injury. The results showed alterations in neural functioning during cognitive control up to 4 months post-injury, regardless of clinical recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Siqi Cai, Zhifeng Shi, Shihui Zhou, Yuchao Liang, Lei Wang, Kai Wang, Lijuan Zhang
Summary: This study investigated the cerebrovascular dynamics in patients with cerebral glioma and their relevance to tumor aggressiveness using time-shift analysis and a decision tree model. The results showed that gliomas induced grade-specific cerebrovascular dysregulation in the entire brain, with altered time-shift features of systemic low-frequency oscillation signals.
Article
Neurosciences
Qingqing Zhang, Samuel R. Cramer, Kevin L. Turner, Thomas Neuberger, Patrick J. Drew, Nanyin Zhang
Summary: In this study, it was found that the multi-phase blood-oxygen-level dependent (BOLD) response observed in the visual cortices of unanesthetized rats during decreased illumination can be better explained by the high-frequency neuronal signal rather than non-neuronal physiological factors. The phases of the BOLD response were found to be reproducible and were not simply a result of the periodic stimulation structure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim Schmidt, S. Johanna Vannesjo, Stefan Sommer, Zoltan Nagy
Summary: By combining HiHi reshuffling with multiband acceleration, we can measure the in vivo BOLD response at a 75-ms sampling rate, decoupled from the acquisition repetition time (1.5 s) and with higher signal-to-noise ratio. This enables coverage of the entire forebrain with 60 2-mm slices in approximately 35 minutes.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Stephen D. Mayhew, Sebastian C. Coleman, Karen J. Mullinger, Cam Can
Summary: This study investigated age-related changes in inhibitory activity in the sensorimotor cortex and found that inhibitory activity decreases with age, leading to declines in motor ability and dexterity. Using a large dataset, the researchers observed that the magnitude and spatial extent of inhibitory activity decrease, while excitatory activity increases with age. The balance between inhibitory and excitatory activity also undergoes changes during the aging process.
Article
Neurosciences
Sharna D. Jamadar, Phillip G. D. Ward, Emma X. Liang, Edwina R. Orchard, Zhaolin Chen, Gary F. Egan
Summary: Simultaneous FDG-PET/fMRI allows imaging of energetic dynamics in the brain, but fPET metabolic connectivity shows little similarity with FDG-sPET metabolic covariance, indicating that individual brain connectivity cannot be inferred from group-level metabolic data. The study highlights the complementary strengths of fPET and fMRI in measuring intrinsic brain connectivity and the potential for novel multimodality biomarkers of neurological diseases.
Article
Multidisciplinary Sciences
Tomokazu Tsurugizawa, Kota Tamada, Nobukazu Ono, Sachise Karakawa, Yuko Kodama, Clement Debacker, Junichi Hata, Hideyuki Okano, Akihiko Kitamura, Andrew Zalesky, Toru Takumi
Article
Multidisciplinary Sciences
Clement Debaker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Bihan
Article
Multidisciplinary Sciences
Yuji Komaki, Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Bihan
Article
Biophysics
Marine A. C. Moussu, Stanislav B. Glybovski, Redha Abdeddaim, Christophe Craeye, Stefan Enoch, Denis Tihon, Sergej Kurdjumov, Marc Dubois, Elodie Georget, Andrew G. Webb, Pavel Belov, Luisa Ciobanu
NMR IN BIOMEDICINE
(2020)
Article
Biochemical Research Methods
Michele Lecis, Solene Bardin, Catalin Ciobanu, Luisa Ciobanu
Summary: CEST is a powerful metabolic imaging technique, but extracting quantitative information from Z-spectra remains challenging. The PEAKIT tool, as an alternative approach, can help identify CEST peaks and output related information.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Bardin, Michele Lecis, Davide Boido, Celine Boutin, Giovanna Baron, Giancarlo Aldini, Patrick Berthault, Fawzi Boumezbeur, Luisa Ciobanu
Summary: This study successfully detected carnosine, anserine, and homocarnosine in vivo using chemical exchange saturation transfer (CEST) at 17.2T. The CEST-linescan approach showed robustness and favorable conditions for CEST at ultra-high magnetic field, allowing the non-invasive investigation of the (patho)-physiological roles of these molecules.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biochemical Research Methods
Daniel Schache, Solene Bardin, Luisa Ciobanu, Cornelius Faber, Verena Hoerr
Summary: We implemented a fast magnetic resonance technique based on chemical exchange saturation transfer (CEST) line scanning to measure the mutarotation kinetics of sugars. The technique allows for ultrafast data acquisition and provides accurate results comparable to conventional measurement methods.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Neurosciences
Marine Tournissac, Davide Boido, Manon Omnes, Yannick Goulam Houssen, Luisa Ciobanu, Serge Charpak
Summary: This article introduces a transparent, stable, and inexpensive chronic cranial window preparation that is suitable for multimodal imaging, allowing the study of different imaging modalities in the same animal.
Article
Multidisciplinary Sciences
Tomokazu Tsurugizawa, Takuma Kumamoto, Yoshichika Yoshioka
Summary: We developed a new ex vivo microimaging protocol using potato starch suspension to address the image quality issues and motion artifacts in mouse embryo microimaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thaddee Delebarre, Vincent Gras, Franck Mauconduit, Alexandre Vignaud, Nicolas Boulant, Luisa Ciobanu
Summary: The purpose of this study is to optimize the homogeneity of presaturation module in a CEST acquisition using pTx at 7T. An optimized pTx-CEST presaturation scheme is designed based on precomputed universal pulses, and the optimization is performed by minimizing the L2-norm between the effective B1,RMS+ and a given target under VOPs supervision. The proposed method is evaluated through simulations and experiments and shows superior performance compared to CP and other pTx approaches.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Keigo Hikishima, Tomokazu Tsurugizawa, Kazumi Kasahara, Ryo Takagi, Kiyoshi Yoshinaka, Naotaka Nitta
Summary: Functional ultrasound (fUS) imaging provides a method for visualizing deep brain activity by measuring cerebral blood volume changes coupled with neural activity, while functional MRI (fMRI) relies on the blood-oxygenation-level-dependent signal. Resting-state functional MRI (rsfMRI) allows for whole brain functional imaging and estimation of resting-state networks (RSNs). Recent research suggests that fUS can provide similar RSNs to fMRI but with higher temporal resolution and stronger correlation with neural activity. These findings have the potential to advance our understanding of functional brain networks and their relationships with disease models.
Article
Multidisciplinary Sciences
Tomokazu Tsurugizawa, Ai Taki, Andrew Zalesky, Kazumi Kasahara
Summary: Hand preference is a behavioral expression of brain lateralization. This study used the gPPI approach to investigate functional connectivity changes during single-hand movement in right-hand subjects. The results showed increased functional connectivity in interhemispheric motor-related regions during non-dominant hand movement, while there was no increase during dominant hand movement. Additionally, the combination of GLM and gPPI analysis can more clearly detect hand preference lateralization.
Article
Biochemical Research Methods
Tomokazu Tsurugizawa, Takuma Kumamoto, Yoshichika Yoshioka
Summary: Potato starch suspension (PSS) shows potential in addressing issues related to micro-magnetic resonance imaging (micro-MRI) of ex vivo embryos, such as air bubbles and specimen motion. This paper presents a protocol for using PSS in micro-MRI scanning, including steps for sample and potato starch preparation with phosphate-buffered saline, as well as specimen immersion and micro-MRI scanning. The protocol is applicable not only to embryos but also to other specimens like insects. For complete details, please refer to Tsurugizawa et al.1.
Article
Engineering, Electrical & Electronic
Marine A. C. Moussu, Redha Abdeddaim, Marc Dubois, Elodie Georget, Andrew G. Webb, Elizaveta Nenasheva, Pavel Belov, Stanislav Glybovski, Luisa Ciobanu, Stefan Enoch
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2020)