期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 7, 页码 2421-2424出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201509515
关键词
dimerization; dyes; gold nanoparticles; luminescence; pH sensors
资金
- NIH [R01DK103363]
- CPRIT [RP140544]
- TexasMRC award
- University of Texas at Dallas
Synergistic effects arising from the conjugation of organic dyes onto non-luminescent metal nanoparticles (NPs) have greatly broadened their applications in both imaging and sensing. Herein, we report that conjugation of a well-known pH-insensitive dye, tetramethyl-rhodamine (TAMRA), to pHinsensitive luminescent gold nanoparticles (AuNPs) can lead to an ultrasmall nanoindicator that can fluorescently report local pH in a ratiometric way. Such synergy originated from the dimerization of TAMRA on AuNPs, of which geometry was very sensitive to surface charges of the AuNPs and can be reversely modulated through protonation of surrounding glutathione ligands. Not limited to pH-insensitive dyes, this pH-dependent dimerization can also enhance the pH sensitivity of fluorescein, a well-known pH-sensitive dye, within a larger pH range, opening up a new pathway to design ultrasmall fluorescent ratiometric nanoindicators with tunable wavelengths and pH response ranges.
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