期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 25, 页码 7101-7105出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601574
关键词
asymmetric sulfoxidation; bisguanidinium; ion-pair catalysis; lansoprazole; Raman spectroscopy
资金
- NTU [M4080946.110, M4011372.110]
The first enantioselective tungstate-catalyzed oxidation reaction is presented. High enantioselectivities were achieved for a variety of drug-like phenyl and heterocyclic sulfides under mild conditions with H2O2, a cheap and environmentally friendly oxidant. Synthetic utility was demonstrated through the preparation of (S)-Lansoprazole, a commercial proton-pump inhibitor. The active ion-pair catalyst was identified to be bisguanidinium diphosphatobisperoxotungstate using Raman spectroscopy and computational studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据