期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 40, 页码 12316-12320出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201607426
关键词
dinitrogen activation; hydrides; nitriles; organometallics; titanium
资金
- Japan Society for Promotion of Science (JSPS) [26220802, 26410082]
- National Science Foundation of China (NSFC) [21429201]
- Grants-in-Aid for Scientific Research [26410082] Funding Source: KAKEN
At present, ammonia (NH3), produced by the energy-intensive Haber-Bosch process, is the only nitrogen source for the industrial preparation of nitrogen-containing organic products. Although the activation and functionalization of dinitrogen (N-2) under milder conditions have received much recent interest, studies on the direct use of N-2 as a feedstock for organic synthesis are still in their infancy. Herein we report the synthesis of nitriles using titanium-activated nitrogen species as a nitrogen source. We have found that a mixed diimide/dinitride tetranuclear titanium complex generated by N-2 activation serves as a unique platform for the synthesis of nitriles through reaction with acid chlorides. This protocol features simple reaction condition (60 degrees C in benzene), no requirement for extra reagents, and unprecedented functional group tolerance (compatible with aromatic C-X (X = Cl, Br, I) bonds, nitro group, and ammonia-sensitive aldehyde and chloromethyl moieties).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据