期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 19, 页码 5814-5818出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201511728
关键词
asymmetric synthesis; biological activity; chirality; elimination; silicon
资金
- JSPS [24350048, 15K13697, 15J07532]
- MEXT Project of Integrated Research on Chemical Synthesis
- Grants-in-Aid for Scientific Research [15J07532, 15K13697] Funding Source: KAKEN
A variety of functionalized silacyclopentanes were synthesized by highly enantioselective -eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the -elimination was elucidated by DFT calculations. An invitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.
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