Article
Materials Science, Multidisciplinary
Lei Xin, Lei Wang, Qian Wang, Jian Meng, Jinfang Gao, Ruiping Zhang
Summary: In this study, water-soluble nanoparticles PFGH with excellent photothermal properties were successfully prepared using a reversed-phase precipitation self-assembly method, expanding the application of PB in the field of biomaterials.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Gang Song, Fengting Lv, Yiming Huang, Haotian Bai, Shu Wang
Summary: Gene therapy is important for disease treatment, and improving gene delivery efficiency and precise gene expression control are crucial. Conjugated polymers have been widely used in bio-sensing, biomedical, and gene-based therapies, enabling DNA and siRNA delivery, as well as photothermal-responsive control of gene expression.
Article
Engineering, Biomedical
Nian Liu, Patrick O'Connor, Vipul Gujrati, Dimitris Gorpas, Sarah Glasl, Andreas Blutke, Axel Walch, Karin Kleigrewe, Michael Sattler, Oliver Plettenburg, Vasilis Ntziachristos
Summary: This study introduces the use of CR760 for nanoparticle formulation, optoacoustic imaging, and photothermal therapy. CR760 exhibits excellent optical properties, can be conveniently prepared in a single step, and can be covalently attached to cancer-targeting ligands to form nanoparticles with active tumor-targeting capability.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Photothermal therapy (PTT) has gained considerable attention in cancer treatment for its unique features, and polymer-based photothermal agents (PTAs) have been widely employed in cancer diagnosis and PTT due to their competitive advantages, including customizable designs, controllable synthesis, excellent biocompatibility, negligible cytotoxicity, satisfactory photostability, and desirable photothermal effects.
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Scientists have made significant efforts in cancer control, with photothermal therapy (PTT) emerging as a promising treatment method. Polymer-based PTAs play a crucial role in cancer diagnosis and therapy, offering various advantages in terms of design, synthesis, biocompatibility, and therapeutic effects.
Review
Biochemistry & Molecular Biology
Rodrigo A. Ponzio, Luis E. Ibarra, Estefania E. Achilli, Emmanuel Odella, Carlos A. Chesta, Sol R. Martinez, Rodrigo E. Palacios
Summary: The increasing pandemic of antibiotic resistant pathogens has resulted in a rising number of untreated infections. Innovative antibiotics are in short supply globally, which further contributes to the emergence and spread of drug resistant microbes. In this paper, the potential of light-mediated therapies, particularly using conjugated polymers (CPs), for combating multidrug-resistance microbes is discussed. CPs possess unique characteristics that make them a powerful class of photosensitizer/photothermal agent materials. The challenges and needs in evaluating the efficiency of phototherapies are also addressed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Polymer Science
Jinghan Ren, Zhanshuo Cao, Minghui Wang, Dong Gao, Chengfen Xing
Summary: Surface-functionalized amphiphilic conjugated polymer-based nanoparticles with photothermal conversion capacity for pH-responsive targeting of bacteria were developed. The pH-sensitive properties of the nanoparticles promote their adhesion to bacterial surfaces and enhance the ablation efficiency of biofilms under the synergistic photothermal effect. This method provides a potential design option for biocompatible light-responsive nanoparticles for in vivo applications.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Nan Li, Yahao Dai, Yang Li, Shilei Dai, Joseph Strzalka, Qi Su, Nickolas De Oliveira, Qingteng Zhang, P. Blake J. St Onge, Simon Rondeau-Gagne, Yunfei Wang, Xiaodan Gu, Jie Xu, Sihong Wang
Summary: Polymer semiconductors have great potential for human-integrated electronics due to their solution processability and mechanical softness. The click-to-polymer (CLIP) synthesis strategy developed by the authors allows for the attachment of diverse functional units to pre-synthesized conjugated-polymer precursors, resulting in functionalized polymers with good charge-carrier mobility. This approach can advance the state of the art by enriching the functional properties of conjugated polymers.
Article
Chemistry, Multidisciplinary
Wei Zhang, Wenhai Lin, Zhensheng Li, Tingting Sun, Zhigang Xie
Summary: Photothermal therapy (PTT) is an effective tumor therapeutic method, but the overexpression of heat shock proteins (HSPs) and the self-repair mechanism of malignant tumors may limit its efficacy. A nanoplatform (IBDDP&GOx NPs) integrating PTT, starvation therapy, and oxidation therapy was developed using a conjugated polymer (IBDDP) and glucose oxidase (GOx). This nanoplatform effectively combines the photothermal properties of IBDDP and the biological catalytic activity of GOx, resulting in enhanced inhibitory effects on tumor cell survival and proliferation.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Jinchao Wei, Ying Liu, Jie Yu, Ling Chen, Mai Luo, Lele Yang, Peng Li, Shengliang Li, Xiao-Hong Zhang
Summary: Conjugated polymers have shown significant progress in bioimaging and cancer therapy, with advancements in optimizing optical properties and design strategies to overcome challenges. New applications in phototherapy of tumors and assistant drug therapy have also been explored, providing future directions for development.
Article
Biochemistry & Molecular Biology
Tianbao Wang, Jiahui Yang, Hongmei Kang, Liangke Zhang, Huan Chen
Summary: This study successfully prepared a novel type of nanoparticle by embedding hyaluronic acid, which exhibited good biosafety and efficient conversion of near-infrared laser energy to thermal energy. The active targeting capability mediated by hyaluronic acid significantly increased the uptake of nanoparticles by tumor cells, resulting in strong growth inhibitory effect on tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Soo-Young Jang, In-Bok Kim, Yunseul Kim, Dae-Hee Lim, Hongkyu Kang, Martin Heeney, Dong-Yu Kim
Summary: Direct arylation polymerization (DArP) is a sustainable method for synthesizing conjugated polymers, with comparable optoelectronic properties to traditional methods. PDCBT synthesized by DArP can be used as a donor material in organic solar cells.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Sainan Liu, Zhendong Liu, Qi Meng, Changxiao Chen, Maolin Pang
Summary: In this research, a cubic porphyrin-based COF named CTP with excellent hydrophilicity was prepared for the first time using a simple method. By linking the porphyrin monomer into the COF, solubility and biocompatibility issues were overcome, and the band gap was narrowed. The resulting CTP showed enhanced sonodynamic effect and photothermal conversion under external irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Bo Chen, Lan Mei, Rangrang Fan, Yuelong Wang, Chunlai Nie, Aiping Tong, Gang Guo
Summary: Stimuli-responsive DNA nanostructure-based nanodevices have been utilized for cancer therapy by constructing drug nanocarriers with pH-responsive i-motif DNA on gold nanoparticles. The multifunctional drug carrier demonstrated potential for synergistic photothermal-chemotherapy, achieving efficient anticancer efficiency through targeted cellular uptake and the synergistic effect between chemotherapy and photothermal therapy utilizing the excellent photothermal conversion efficiency of AuNPs under near-infrared irradiation.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Beilei Gong, Yuanbing Shen, Huiyan Li, Xiaojun Li, Xia Huan, Jihong Zhou, Yuqing Chen, Jian Wu, Wei Li
Summary: Gold nanoparticles are considered a versatile platform for biomedical applications due to their strong and tunable surface plasmon resonance effect and good biocompatibility. This study designed a new nanoplatform incorporating gold nanorods and indocyanine green to enhance photodynamic/photothermal combination therapy. The polymer shell in the nanoplatform has thermo-responsive characteristics that control drug release at tumour sites, leading to increased drug aggregation and improved therapeutic efficacy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiang Shi, Ge Gao, Xiaoyang Liu, Lingling Xu, Yu Deng, Rui Wang, Gaolin Liang
Summary: Lipid droplet (LD) fluorescent imaging plays an important role in the detection of lipid-related diseases. However, currently available LD imaging fluorophores have limitations in terms of photostability and hydrophobicity. This study introduces a highly lipophilic compound, Cou-Flu, which exhibits excellent photostability and excimer-monomer transition property. Cou-Flu enables high contrast LD imaging and LD movement tracing in cells, and it is also suitable for in vivo LD detection with excellent sensitivity.
CHINESE CHEMICAL LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Chang Xie, Li Wang, Yajuan Liu, Muqing Chen, Pingwu Du, Yucai Wang, Xiaopeng Ma, Shangfeng Yang
Summary: Photothermal therapy (PTT) using near-infrared-II (NIR-II) light is an effective tumor therapy technique with deeper tissue penetration and higher laser power density. Black phosphorus (BP) has potential applications in PTT, but its low stability and limited photothermal conversion efficiency pose challenges. In this study, fullerene covalently modified few-layer BP nanosheets (BP-ester-C60) were developed to enhance stability and photothermal conversion efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Xianbao Sun, Tiantian Xia, Lingling Xu, Wenjun Zhan, Gaolin Liang
Summary: Featuring molecule-level data encryption, molecular keypad locks offer attractive advantages in information security. Previous multiple-input locks using fluorescence as the output have encountered challenges due to inefficient prequenching or the synthetic complexity of fluorophore-containing processor molecules. In this study, we propose a simple and label-free three-input molecular keypad lock, capable of generating fluorescent readout without background interference. The correct password leads to the generation of a fluorescent product, while incorrect inputs fail to open the lock. This device shows potential for further development into an advanced and secure keypad lock.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Yi Liu, Wang Dong, Yinchu Ma, Jiaxiang Dou, Wei Jiang, Li Wang, Qin Wang, Shuya Li, Yucai Wang, Min Li
Summary: Tumor hypoxia heterogeneity, a characteristic feature of the tumor microenvironment, leads to resistance to chemotherapy. To overcome this, a nanomedicine called NPHPaPN was developed, which utilizes hypoxia-responsive PEG shell deshielding and drug internalization through the HA-CD44 pathway to target cisplatin-resistant tumor cells. The release of cisplatin prodrug and a DNA damage repair inhibitor within the tumor cells enhances drug sensitivity and leads to significant tumor growth suppression with an inhibition rate of approximately 84.4%.
Article
Chemistry, Multidisciplinary
Youcui Xu, Chang Yang, Yi Wu, Wei Jiang, Quan Cheng, Lifeng Yan, Kaige Chen, Yucai Wang
Summary: Researchers have developed a fluorescent probe called IR1080 to detect micrometastases in cancer patients, which can be used for fluorescence image-guided surgery. IR1080 binds rapidly to albumin in plasma, resulting in increased fluorescence brightness. It also has a high affinity for SPARC, an albumin-binding protein overexpressed in micrometastases. The interaction between SPARC and IR1080 leads to a high detection rate and accurate delineation of tumor margins, making IR1080 an efficient strategy for the diagnosis and image-guided surgery of micrometastases.
Article
Chemistry, Multidisciplinary
Min Li, Han Zhou, Namei Wu, Wuxian Deng, Wang Dong, Xun Sun, Hang Liu, Zhigang Tian, Yucai Wang
Summary: We describe a novel bacterial nanomedicine (BNM) system for pathogen recognition-mediated DCs-specific gene silencing and gene editing. The targeting efficiency of BNMs is reduced in DCs lacking toll-like receptor 4, which is responsible for recognizing lipopolysaccharide. As a proof-of-concept demonstration, gene-based therapy mediated by BNMs enhances antigen cross-presentation in DCs and generates a remarkable antitumor effect.
Article
Nanoscience & Nanotechnology
Wenxiu Duan, Lifeng Hang, Yinchu Ma, Qin Wang, Xinfeng Tang, Wei Jiang, Yi Wu, Weifu Lv, Yucai Wang
Summary: Nano-metal-organic frameworks (nMOFs) can load and protect bioactive macromolecules, and selectively release them at the target location after stimulation, showing promising applications in co-delivery of biomacromolecules.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kaige Chen, Zheng Zhang, Ziyuan Fang, Jiachen Zhang, Qian Liu, Wang Dong, Yang Liu, Yucai Wang, Jun Wang
Summary: This study reports a nano-mediated strategy to stimulate the precise clearance of activated neutrophils using an artificial aged signal, thus alleviating inflammation. The findings show that this strategy effectively targets and clears activated neutrophils, preventing inflammatory responses and tissue damage.
Article
Chemistry, Multidisciplinary
Guangqiong Xu, Qiao Weng, Lei Zhang, Yaye Song, Wenjun Zhan, Yuan Yin, Gaolin Liang, Fuqiang Wang
Summary: This study reports an AURKB-responsive hydrogel, Gel S/AZD, which enhances cervical tumor suppression by controlled release of AZD1152. Cell assays show that Gel S/AZD induces growth arrest and apoptosis of cervical cancer cells by downregulating the expression of AURKB downstream protein pH3. In vivo studies demonstrate that Gel S/AZD exhibits superior tumor suppressive effect in orthotropic cervical tumor models.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Xinyi Hu, Xianbao Sun, Xiaoyang Liu, Hai-Dong Xu, Liang Yang, Songqin Liu, Rui Wang, Gaolin Liang
Summary: This study introduces a new molecular probe for photoacoustic imaging, which shows promising results for early diagnosis of breast cancer. The experimental results demonstrate that the molecular probe enhances the activity of urokinase-type plasminogen activator and holds great potential for application in both in vitro and in vivo settings.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qian Liu, Li Wang, Yitan Su, Wang Dong, Huiru Wang, Yang Liu, Hang Liu, Lianxin Liu, Yucai Wang
Summary: Protein drugs are potential candidates for treating complex diseases like cancer. Metal-organic-framework (MOF) is considered a promising carrier for encapsulating protein drugs, but its limited loading efficiency and potential toxicity hinder its clinical application. In this study, a tumor targeted collagenase-encapsulating MOF (PMOCol) is developed for refining deep tissue pancreatic cancer photoimmunotherapy. PMOCol demonstrates high encapsulation efficiency (80.3 wt%) and can effectively regulate extracellular matrix, enhancing immunocyte infiltration for cancer immunotherapy. By integrating a hyperthermia agent, PMOCol induces acute immunogenicity and systemic immune memory to prevent tumor development and recurrence.
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Analytical
Ying Xu, Qiaochu Jiang, Xianbao Sun, Gaolin Liang
Summary: Stimuli-triggered in-situ morphological transformation of peptide nanomaterials can enhance the on-site accumulation and retention of imaging agent cargos, enabling precise, sensitive, and prolonged disease imaging. This strategy allows for the co-delivery of contrast agents and drugs with smart turn-on ability, facilitating efficient disease theranostics. This review highlights the bioimaging applications of these smart morphological transformation-based peptide materials, and discusses the challenges in this field.
ANALYSIS & SENSING
(2023)
Review
Nanoscience & Nanotechnology
Xinyi Hu, Runqun Tang, Lin Bai, Songqin Liu, Gaolin Liang, Xianbao Sun
Summary: Derived from the D-luciferin regeneration pathway in firefly body, the CBT-Cys click reaction possesses unique advantages and has been used to fabricate stimuli-activatable imaging probes with self-assembling behaviors in physiological context. The in situ formed nanostructures enable precise and enhanced in vivo imaging of diseases, especially tumors.
Article
Chemistry, Multidisciplinary
Lingling Xu, Hang Gao, Wenjun Zhan, Yu Deng, Xiaoyang Liu, Qiaochu Jiang, Xianbao Sun, Jing-Juan Xu, Gaolin Liang
Summary: This study successfully achieves enhanced imaging of Alzheimer's disease by designing a near-infrared AIEgen with dual aggregation properties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
