Article
Biochemistry & Molecular Biology
Masato Mashimo, Akane Morozumi, Akari Nobeyama, Misato Kanzaki, Shigeru Negi, Jiro Kato, Joel Moss, Atsuo Nomura, Takeshi Fujii
Summary: Parthanatos is a programmed cell death process mediated by PARP1, which inhibits endocytosis by binding to Rab5, leading to cell starvation and death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tarek El-Hamoly, Zoltan Hajnady, Mate Nagy-Penzes, Edina Bakondi, Zsolt Regdon, Mate A. Demeny, Katalin Kovacs, Csaba Hegedus, Sahar S. Abd El-Rahman, Eva Szabo, Jozsef Maleth, Peter Hegyi, Laszlo Virag
Summary: PARP1 plays an important role in the pathogenesis of chronic pancreatitis, and the PARP inhibitor olaparib has protective effects in a mouse model of CP by reducing inflammation and fibrosis. This suggests that PARP inhibitors may be promising candidates for treating both acute and chronic pancreatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yves Pommier, Anish Thomas
Summary: ADCs are effective in delivering cytotoxic agents to tumors, and two ADCs delivering TOP1 poisons have been FDA-approved. A recent study introduced a TOP1-anti B7-H4 ADC that showed synergistic effect with a PARP1-selective inhibitor.
CLINICAL CANCER RESEARCH
(2023)
Article
Biology
Sridevi Challa, Keun W. Ryu, Amy L. Whitaker, Jonathan C. Abshier, Cristel Camacho, W. Lee Kraus
Summary: In this study, PAR Trackers were developed and characterized as highly sensitive tools for detecting ADPR in various experimental and biological systems, providing greater temporal and spatial precision.
Article
Oncology
William P. Tew, Christina Lacchetti, Elise C. Kohn
Summary: ASCO Rapid Recommendations Updates provide revisions to select ASCO guideline recommendations based on new and practice-changing data. The goal is to disseminate updated recommendations in a timely manner to inform health practitioners and the public on the best available cancer care options.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Michael S. Cohen
Summary: ADP-ribosylation is a crucial post-translational modification, involving MAR and PAR. Researchers have identified distinct MAR and PAR readers using a chemical biology approach.
Article
Chemistry, Medicinal
Ananda Guha Majumdar, Shikha Shree, Amit Das, Binita K. Kumar, Papiya Dey, Mahesh Subramanian, Birija Sankar Patro
Summary: In this study, a library of candidate dual inhibitors for PARP1 and TOP1 was designed, synthesized and evaluated. DiPT-4 showed promising cytotoxicity against multiple cancers with limited toxicities towards normal cells. Mechanistically, DiPT-4 inhibited the activity of TOP1 and PARP1, inducing DNA double strand breaks, cell cycle arrest and apoptosis in cancer cells. Moreover, DiPT-4 inhibited the PARylation of TOP1cc, leading to long lived TOP1cc with a slower degradation kinetics. These findings suggest that DiPT-4 may serve as a promising dual inhibitor of TOP1 and PARP1 in clinical settings.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Ming-hao Liu, Feng-zheng Li, Wen-jing Liu, Juan Hu, Meng Liu, Chun -Yang Zhang
Summary: A ultrasensitive chemiluminescent biosensor was developed for rapid detection of PARP-1 in human breast tissues. The biosensor combines PARP-1-directed hyperbranched poly(ADP-ribose) formation with alkaline phosphatase-mediated chemiluminescence system. It offers high sensitivity, accuracy, and potential applications in cancer diagnosis and biomedical research.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Emad Matanes, Vanessa M. Lopez-Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Oded Raban, Liron Kogan, Shannon Salvador, Susie Lau, Walter H. Gotlieb, Amber Yasmeen
Summary: The study showed that PARG inhibition can complement PARP inhibition in the treatment of ovarian cancer, especially in the presence of homologous recombination defects. PARG inhibitor alone or in combination with PARPi or Cisplatin can reduce cell migration and induce cell death.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keum-Young So, Seon-Hee Oh
Summary: Arsenic induces a distinctive cell death mode via PARP-1 activation in p53-deficient cells. This cell death is promoted by autophagy inhibition. These findings suggest that PARP-1 activation could be used as an effective therapeutic approach for arsenic toxicity in p53-deficient cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Ning Xia, Daohong Wu, Ting Sun, Yilin Wang, Xiaoyu Ren, Feng Zhao, Lin Liu, Xinyao Yi
Summary: PARP-1 is a conserved nuclear enzyme that catalyzes the transfer of ADP-ribose units, and this study utilized boronic acid derivatives as signal probes for electrochemical and colorimetric detection of PARP-1. A detection platform was constructed by modifying double-stranded DNA on magnetic beads surface, allowing for efficient monitoring of PARP-1 activity and concentration.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Fengli Gao, Gang Liu, Yishu Qiao, Xiuwen Dong, Lin Liu
Summary: This study presents a fluorescence method for detecting poly(ADP-ribose) polymerase-1 (PARP1) using a boronic acid-modified fluorescein isothiocyanate dye. The method involves the conjugation of recombinant streptavidin with PARP1-specific double-stranded DNA and the capture and separation of PAR conjugates using a nickel ion-modified magnetic bead. The method shows a wide linear range and low detection limit, making it valuable for biosensor development.
Article
Biochemistry & Molecular Biology
David Hutin, Karoline Alvik Hagen, Peng Shao, Kim Sugamori, Denis M. Grant, Jason Matthews
Summary: PARP7 is an important regulator of the immune system, and is involved in intestinal inflammation. Loss of PARP7 impairs immune response to colon inflammation, possibly due to its role in IFN-I signaling rather than AHR signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Cassandra L. R. van Doorn, Sanne A. M. Steenbergen, Kimberley V. Walburg, Tom H. M. Ottenhoff
Summary: The inhibition of PARP has been shown to reduce the levels of Mycobacterium tuberculosis (Mtb) in human macrophages, indicating that PARP could be a potential target for developing innovative host-directed therapies against Mtb.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Oncology
Keun-Yeong Jeong, Haejun Lee
Summary: Chemotherapeutic regimens for pancreatic cancer are limited as it is typically diagnosed in advanced stages and hard to detect early symptoms. Mutations in BRCA leading to reduced susceptibility to conventional chemotherapies offer a new perspective, emphasizing the key role of PARP-1 in genomic instability.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lin Yuan, Shichen Bu, Meng Du, Yilong Wang, Chenhui Ju, Dandan Huang, Wenjing Xu, Xin Tan, Minglu Liang, Shan Deng, Liu Yang, Kai Huang
Summary: This study investigated the role of RNF207 in the development of pathological cardiac hypertrophy and dysfunction. The results showed that RNF207 exacerbated cardiac hypertrophy and fibrosis, while RNF207 knockdown alleviated these conditions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Wenjing Xu, Sheli Zhang, Ruofan Shen, Zhikun Peng, Baozhong Liu, Jun Li, Zhanying Zhang, Baojun Li
Summary: This study investigates the interfacial structure between metal nanoparticles and metal oxides and demonstrates the importance of high-density interfaces in maximizing catalytic activity. By synthesizing a Cu-Co3O4 nanoparticles interfacial structure through pyrolysis and moderate oxidation, the researchers discover the synergistic effect between Cu and Co3O4 nanoparticles at their interface. Density functional theory calculations and in situ Raman spectroscopy reveal the catalytic mechanism of dual active sites.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Wenjing Xu, Zhenghao Shi, Xinmei Yu, Yanyan Xu, Yan Chen, Yinghao He, Yongfang Gong, Chunxia Huang, Chao Tan, Yan Yang
Summary: Sal B delays the progression of liver fibrosis-carcinoma and inhibits the growth of liver cancer cells by promoting the conversion of pSmad3L to pSmad3C. Sal B also regulates the Hippo/YAP pathway, which contributes to its anti-HCC effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Fisheries
Qieqi Qian, Zhen Chen, Jingwen Xu, Yujie Zhu, Wenjing Xu, Xiaojian Gao, Qun Jiang, Xiaojun Zhang
Summary: This study identified Plesiomonas shigelloides as the causative agent of a mass mortality outbreak in an aquaculture farm in Jiangsu province, China, affecting largemouth bass. Pathogenicity of the bacterium was confirmed through challenge experiments, and histopathological analysis revealed extensive necrosis, vacuolization, and inflammation in the affected fish. Virulence-related genes were detected in the bacterial isolate, and a significant upregulation of immune-related genes was observed in the host's organs, indicating transcriptional activation of the host defense system.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Neurosciences
Xiangling Li, Tieyuan Zhang, Chaochao Li, Wenjing Xu, Yanjun Guan, Xiaoya Li, Haofeng Cheng, Shengfeng Chen, Boyao Yang, Yuli Liu, Zhiqi Ren, Xiangyu Song, Zhibo Jia, Yu Wang, Jinshu Tang
Summary: Low-frequency electrical stimulation (ES) promotes nerve regeneration by accelerating Wallerian degeneration (WD) and upregulating the expression of neurotrophic factors, leading to accelerated early axonal and vascular regeneration while delaying muscle atrophy.
Article
Computer Science, Artificial Intelligence
Guiying Zhang, Wenjing Xu, Haotian Gong, Lilei Sun, Cong Li, Huicong Chen, Daoman Xiang
Summary: This study aims to develop an intelligent strabismus detection model driven by corneal light reflection photographs to automatically detect children's strabismus. The proposed multi-feature fusion model (MFFM) improves the detection performance by fusing the deep features and ratio features extracted from the corneal light reflection photographs to identify strabismus. The experimental results demonstrate that our proposed multi-feature model outperforms all of the single feature models in strabismus detection.
IET IMAGE PROCESSING
(2023)
Article
Polymer Science
Lijuan Long, Wenjing Xu, Tao Xu, Guomin Xu, Yushu Xiang, Chunyan Shan, Min He, Shuhao Qin, Jie Yu
Summary: This study systematically and comparatively investigated the flame retardancy of PLA/PBAT composites containing DOPO derivatives. Results showed that different structures of the derivatives exhibit different effects, with DIDOPO demonstrating better flame inhibition and DOPO-HQ providing superior barrier and protective functions.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Infectious Diseases
Ruina Zhang, Yizhen Zhang, Wenjing Xu, Xiaomin Han, Junying Zhao
Summary: This case report presents a rare case of primary cutaneous aspergillosis in an immunocompetent woman following tattooing. The patient presented with erythematous papules, papulopustules, and a plaque on the lower limb which had been unresponsive to antihistamine treatment for over two years. Histological examination revealed spores in the corneous layer, a slightly thickened epidermis, and inflammatory cells around blood vessels in the superficial dermis. Aspergillus fumigatus was isolated and identified in cultures. The lesions resolved completely after systemic antifungal treatment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Tong Liu, Sijie Yao, Wei Jiang, Taohua Lan, Wenjing Xu, Haiming Cao, Ping Yao, Chao Wang, Weihui Lu, Xiankun Chen
Summary: This study introduces a randomized controlled trial to evaluate the efficacy and safety of Xin-Li-Fang (XLF) for chronic heart failure (CHF). The trial is designed as a multicenter, double-blinded study and will be conducted in China. The primary outcome is the proportion of patients whose serum NT-proBNP decreased by more than 30%. The secondary outcomes include various evaluations and clinical events. The study aims to provide high-quality evidence on the efficacy and safety of XLF for CHF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kohei Mishina, Takako Suzuki, Youko Oono, Yoko Yamashita, Hongjing Zhu, Taiichi Ogawa, Masaru Ohta, Kohei Doman, Wenjing Xu, Daichi Takahashi, Taiga Miyazaki, Akemi Tagiri, Chihiro Soma, Harukuni Horita, Shuhei Nasuda, Romain De Oliveira, Etienne Paux, Guoxiong Chen, Mohammad Pourkheirandish, Jianzhong Wu, Cheng Liu, Takao Komatsuda
Summary: Wheat yellow mosaic virus (WYMV) is transmitted by the vector Polymyxa graminis into the roots of its host. The Ym1 and Ym2 genes provide resistance against WYMV, but their mechanisms are not well understood. This study found that Ym1 and Ym2 act in the roots, hindering viral movement or suppressing viral replication. Ym1 reduced viral infection incidence in leaves, while Ym2 did not have an effect. The Ym2 gene was isolated and found to correlate with disease response. Ym2 has undergone structural diversity through translocation and recombination, contributing to the evolution of cultivated wheat.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Multidisciplinary
Xiangyu Xu, Ziqian Sheng, Jueli Shi, Xin Chen, Yaxin He, Wenjing Xu, Xu Zhang, Duanyang Chen, Hongji Qi, Kelvin H. L. Zhang
Summary: The bandgap of (AlxGa1-x)(2)O-3 thin films can be modulated by varying the Al contents, resulting in high-performance photodetectors for solar-blind UV bands. The detection cut-off wavelengths and response peaks of the photodetectors can be tuned by changing the Al contents. The wide variations of the bandgap are mainly due to the upshift of the conduction band edges induced by Al 3s state hybridization.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Physical
Haoxiang Fan, Fengjuan Qin, Qi Yuan, Zhiyi Sun, Hongfei Gu, Wenjing Xu, Hao Tang, Shuhu Liu, Yu Wang, Wenxing Chen, Jia Li, Huazhang Zhai
Summary: This study reports a novel single-atom catalyst supported on vacancy-affluent porous hexagonal boron nitride for efficient and selective conversion reactions. XAFS experiments and DFT calculations suggest that the nitrogen vacancy adjacent to the active center plays a key role in atomic interface regulation. The strongly coupled metal-ligand moiety with an adjacent vacancy may have synergistic effects in heterogeneous catalysis.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Energy & Fuels
Xiaohu Dong, Wenjing Xu, Huiqing Liu, Zhangxin Chen, Ning Lu, Wuchao Wang
Summary: The replacement mechanisms of CO2 in nanopores of shale oil reservoirs are discussed using static tests and molecular dynamics (MD) simulations in this study. Various molecular models of shale oil and shale rock are developed, and MD simulations are conducted to study the replacement behavior of CO2. The concept of replacement efficiency (RE) is proposed to analyze the effects of shale oil composition, porewall mineral type, and CO2 concentration. This study provides new insights into the understanding of CO2 replacement mechanisms in shale oil reservoirs, which is important for their effective and efficient development.
GEOENERGY SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Physical
Wenjing Xu, Yidong Sun, Jiaqi Zhou, Maoqi Cao, Jun Luo, Haili Mao, Pengfei Hu, Hongfei Gu, Huazhang Zhai, Huishan Shang, Zhi Cai
Summary: This study developed a cost-effective and high-efficiency catalyst, CoSA-C2N, for oxygen reduction reaction (ORR) by rationally constructing atomically dispersed Co atoms on porous N-enriched graphene material C2N. The CoSA-C2N catalyst demonstrated superior ORR performance in both acidic and alkaline conditions, as well as impressive long-term durability, providing a novel approach to advanced catalysts for energy-related applications.
Article
Chemistry, Physical
Ming Qu, Zhe Chen, Zhiyi Sun, Danni Zhou, Wenjing Xu, Hao Tang, Hongfei Gu, Tuo Liang, Pengfei Hu, Guangwen Li, Yu Wang, Zhuo Chen, Tao Wang, Binbin Jia
Summary: This study developed nickel single-site catalysts with dual-coordinated phosphorus and nitrogen atoms, which significantly improved the CO2RR activity of the catalyst. Experimental and theoretical results revealed that the asymmetric Ni-P1N3 site facilitated the adsorption/desorption of CO2 intermediates, thereby promoting reaction kinetics and enhancing CO2RR activity.
