The shape of human squalene epoxidase expands the arsenal against cancer

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

(2019) Anil K. Padyana et al.   Nature Communications

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

(2019) Christopher E. Mahoney et al.   Nature Communications

Squalene epoxidase as a promising metabolic target in cancer treatment

(2018) Gabriella Cirmena et al.   CANCER LETTERS

Cholesterol, cancer, and rebooting a treatment for athlete’s foot

(2018) Ngee Kiat Chua et al.   Science Translational Medicine

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron Transfer Pathways in Cholesterol Synthesis

(2015) Todd D. Porter   LIPIDS

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

(2012) Spyridon Theofilopoulos et al.   Nature Chemical Biology

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS